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Detailed solvent, structural, quantum chemical study and antimicrobial activity of isatin Schiff base
dc.creator | Brkić, Dominik R. | |
dc.creator | Božić, Aleksandra R. | |
dc.creator | Marinković, Aleksandar | |
dc.creator | Milčić, Miloš K. | |
dc.creator | Prlainović, Nevena Z. | |
dc.creator | Assaleh, Fathi H. | |
dc.creator | Cvijetić, Ilija | |
dc.creator | Nikolić, Jasmina B. | |
dc.creator | Drmanić, Saga Z. | |
dc.date.accessioned | 2019-07-04T07:51:51Z | |
dc.date.available | 2020-01-30 | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1386-1425 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/3196 | |
dc.description.abstract | The ratios of E/Z isomers of sixteen synthesized 1,3-dihydro-3-(substituted phenylimino)-2H-indol-2-one were studied using experimental and theoretical methodology. Linear solvation energy relationships (LSER) rationalized solvent influence of the solvent-solute interactions on the UV-Vis absorption maxima shifts (v(max)) of both geometrical isomers using the Kamlet-Taft equation. Linear free energy relationships (LEER) in the form of single substituent parameter equation (SSP) was used to analyze substituent effect on pK(a), NMR chemical shifts and v(max) values. Electron charge density was obtained by the use of Quantum Theory of Atoms in Molecules, i.e. Bader's analysis. The substituent and solvent effect on intramolecular charge transfer (ICT) were interpreted with the aid of time-dependent density functional (TD-DFT) method. Additionally, the results of TD-DFT calculations quantified the efficiency of ICT from the calculated charge-transfer distance (D-CT) and amount of transferred charge (Q(CT)). The antimicrobial activity was evaluated using broth microdilution method. 3D QSAR modeling was used to demonstrate the influence of substituents effect as well as molecule geometry on antimicrobial activity. (C) 2018 Elsevier B.V. All rights reserved. | en |
dc.publisher | Pergamon-Elsevier Science Ltd, Oxford | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172013/RS// | |
dc.rights | embargoedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Spectrochimica Acta. Part A: Molecular and Biomolecular Spectroscopy | |
dc.subject | E/Z isomers | en |
dc.subject | Solvent effects | en |
dc.subject | Substituent effects | en |
dc.subject | Bader's analysis | en |
dc.subject | TD-DFT, 3D QSAR | en |
dc.title | Detailed solvent, structural, quantum chemical study and antimicrobial activity of isatin Schiff base | en |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Цвијетић, Илија; Бркић, Доминик Р.; Божић, Aлександра Р.; Маринковић, Aлександар; Прлаиновић, Невена З.; Николић, Јасмина Б.; Дрманић, Сага З.; Милчић, Милош К.; Aссалех, Фатхи Х.; | |
dc.citation.volume | 196 | |
dc.citation.spage | 16 | |
dc.citation.epage | 30 | |
dc.identifier.wos | 000428833000003 | |
dc.identifier.doi | 10.1016/j.saa.2018.01.080 | |
dc.citation.other | 196: 16-30 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 29428893 | |
dc.description.other | This is peer-reviewed version of the following article: Brkić, D. R.; Božić, A. R.; Marinković, A. D.; Milčić, M. K.; Prlainović, N. Ž.; Assaleh, F. H.; Cvijetić, I. N.; Nikolić, J. B.; Drmanić, S. Ž. Detailed Solvent, Structural, Quantum Chemical Study and Antimicrobial Activity of Isatin Schiff Base. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy 2018, 196, 16–30. [https://doi.org/10.1016/j.saa.2018.01.080] | |
dc.description.other | Supplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3197] | |
dc.type.version | acceptedVersion | en |
dc.identifier.scopus | 2-s2.0-85041496731 | |
dc.identifier.fulltext | https://cherry.chem.bg.ac.rs/bitstream/id/7889/Detailed_solvent_structural_acc_2018.pdf |