The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1
Authors
Apostolović, DanijelaSanchez-Vidaurre, Sara
Waden, Konrad
Curin, Mirela
Grundström, Jeanette
Gafvelin, Guro
Ćirković-Veličković, Tanja
Gronlund, Hans
Thomas, Wayne R.
Valenta, Rudolf
Hamsten, Carl
van Hage, Marianne
Article (Accepted Version)
Metadata
Show full item recordAbstract
We investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenic activity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation between IgE levels to rFel d 7 and rCan f 1 was found. rFel d 7 activated basophils in vitro and inhibited IgE binding to rCan f 1 in 4 of 13 patients, whereas rCan f 1 inhibited IgE binding to rFel d 7 in 7 of 13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found using cross-reactive antisera. Fel d 7 is a common allergen in a Swedish cat-sensitized population that cross-reacts with Can f 1, and may contribute to symptoms in cat-but also in dog-allergic patients.
Keywords:
Can f 1 / cat allergy / cross-reactivity / dog allergy / Fel d 7Source:
Allergy, 2016, 71, 10, 1490-1495Publisher:
- Wiley-Blackwell, Hoboken
Funding / projects:
- Molecular properties and modifications of some respiratory and nutritional allergens (RS-MESTD-Basic Research (BR or ON)-172024)
- Reinforcement of the Faculty of Chemistry, University of Belgrade, towards becoming a Center of Excellence in the region of WB for Molecular Biotechnology and Food research (EU-FP7-256716)
- Stockholm County Council
- Karolinska Institutet
- Austrian Science Fund (FWF) [F4605]
- Swedish Association for Allergology
- Swedish Cancer and Allergy Foundation
- King Gustaf V 80th Birthday Foundation
- Magnus Bergvall Foundation
- Swedish Research Council
- Swedish Asthma and Allergy Associations Research Foundation
- Swedish Heart-Lung Foundation
- Center for Inflammatory Diseases
- Hesselman Foundation
Note:
- This is peer-reviewed version of the following article: Apostolovic, D.; Sánchez-Vidaurre, S.; Waden, K.; Curin, M.; Grundström, J.; Gafvelin, G.; Cirkovic Velickovic, T.; Grönlund, H.; Thomas, W. R.; Valenta, R.; et al. The Cat Lipocalin Fel d 7 and Its Cross-Reactivity with the Dog Lipocalin Can f 1. Allergy: European Journal of Allergy and Clinical Immunology 2016, 71 (10), 1490–1495. https://doi.org/10.1111/all.12955
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/3651
DOI: 10.1111/all.12955
ISSN: 0105-4538
PubMed: 27289080
WoS: 000386085800014
Scopus: 2-s2.0-84978909754
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Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Apostolović, Danijela AU - Sanchez-Vidaurre, Sara AU - Waden, Konrad AU - Curin, Mirela AU - Grundström, Jeanette AU - Gafvelin, Guro AU - Ćirković-Veličković, Tanja AU - Gronlund, Hans AU - Thomas, Wayne R. AU - Valenta, Rudolf AU - Hamsten, Carl AU - van Hage, Marianne PY - 2016 UR - https://cherry.chem.bg.ac.rs/handle/123456789/3650 AB - We investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenic activity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation between IgE levels to rFel d 7 and rCan f 1 was found. rFel d 7 activated basophils in vitro and inhibited IgE binding to rCan f 1 in 4 of 13 patients, whereas rCan f 1 inhibited IgE binding to rFel d 7 in 7 of 13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found using cross-reactive antisera. Fel d 7 is a common allergen in a Swedish cat-sensitized population that cross-reacts with Can f 1, and may contribute to symptoms in cat-but also in dog-allergic patients. PB - Wiley-Blackwell, Hoboken T2 - Allergy T1 - The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1 VL - 71 IS - 10 SP - 1490 EP - 1495 DO - 10.1111/all.12955 ER -
@article{ author = "Apostolović, Danijela and Sanchez-Vidaurre, Sara and Waden, Konrad and Curin, Mirela and Grundström, Jeanette and Gafvelin, Guro and Ćirković-Veličković, Tanja and Gronlund, Hans and Thomas, Wayne R. and Valenta, Rudolf and Hamsten, Carl and van Hage, Marianne", year = "2016", abstract = "We investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenic activity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation between IgE levels to rFel d 7 and rCan f 1 was found. rFel d 7 activated basophils in vitro and inhibited IgE binding to rCan f 1 in 4 of 13 patients, whereas rCan f 1 inhibited IgE binding to rFel d 7 in 7 of 13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found using cross-reactive antisera. Fel d 7 is a common allergen in a Swedish cat-sensitized population that cross-reacts with Can f 1, and may contribute to symptoms in cat-but also in dog-allergic patients.", publisher = "Wiley-Blackwell, Hoboken", journal = "Allergy", title = "The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1", volume = "71", number = "10", pages = "1490-1495", doi = "10.1111/all.12955" }
Apostolović, D., Sanchez-Vidaurre, S., Waden, K., Curin, M., Grundström, J., Gafvelin, G., Ćirković-Veličković, T., Gronlund, H., Thomas, W. R., Valenta, R., Hamsten, C.,& van Hage, M.. (2016). The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1. in Allergy Wiley-Blackwell, Hoboken., 71(10), 1490-1495. https://doi.org/10.1111/all.12955
Apostolović D, Sanchez-Vidaurre S, Waden K, Curin M, Grundström J, Gafvelin G, Ćirković-Veličković T, Gronlund H, Thomas WR, Valenta R, Hamsten C, van Hage M. The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1. in Allergy. 2016;71(10):1490-1495. doi:10.1111/all.12955 .
Apostolović, Danijela, Sanchez-Vidaurre, Sara, Waden, Konrad, Curin, Mirela, Grundström, Jeanette, Gafvelin, Guro, Ćirković-Veličković, Tanja, Gronlund, Hans, Thomas, Wayne R., Valenta, Rudolf, Hamsten, Carl, van Hage, Marianne, "The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1" in Allergy, 71, no. 10 (2016):1490-1495, https://doi.org/10.1111/all.12955 . .