Synthesis of two novel C-19 analogues of (±)-alstoscholarisine A
Апстракт
Two new analogues of alstoscholarisine A, containing a phenyl or butyl substituent at the C-19 position, have been prepared in racemic form from the known skatole derivative. The syntheses of these compounds were accomplished in 13 steps, with a late-stage formation of the C-19 stereocenter. These derivatives are expected to have significantly changed biological activity, compared to alstoscholarisine A – a potent neuroactive natural product.
Кључне речи:
Alstonia scholaris / Neuronal stem cells / аlkaloidsИзвор:
Journal of the Serbian Chemical Society, 2019, 84, 9, 935-941Издавач:
- Beograd : Srpsko hemijsko društvo
Финансирање / пројекти:
- Развој нових синтетичких метода и њихова примена у синтези природних производа и биолошки активних једињења (RS-MESTD-Basic Research (BR or ON)-172027)
DOI: 10.2298/JSC190212026B
ISSN: 0352-5139
WoS: 000489023300002
Scopus: 2-s2.0-85072947348
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Bihelović, Filip AU - Ferjančić, Zorana AU - Jončev, Zlatko PY - 2019 UR - https://cherry.chem.bg.ac.rs/handle/123456789/3660 AB - Two new analogues of alstoscholarisine A, containing a phenyl or butyl substituent at the C-19 position, have been prepared in racemic form from the known skatole derivative. The syntheses of these compounds were accomplished in 13 steps, with a late-stage formation of the C-19 stereocenter. These derivatives are expected to have significantly changed biological activity, compared to alstoscholarisine A – a potent neuroactive natural product. PB - Beograd : Srpsko hemijsko društvo T2 - Journal of the Serbian Chemical Society T1 - Synthesis of two novel C-19 analogues of (±)-alstoscholarisine A VL - 84 IS - 9 SP - 935 EP - 941 DO - 10.2298/JSC190212026B ER -
@article{ author = "Bihelović, Filip and Ferjančić, Zorana and Jončev, Zlatko", year = "2019", abstract = "Two new analogues of alstoscholarisine A, containing a phenyl or butyl substituent at the C-19 position, have been prepared in racemic form from the known skatole derivative. The syntheses of these compounds were accomplished in 13 steps, with a late-stage formation of the C-19 stereocenter. These derivatives are expected to have significantly changed biological activity, compared to alstoscholarisine A – a potent neuroactive natural product.", publisher = "Beograd : Srpsko hemijsko društvo", journal = "Journal of the Serbian Chemical Society", title = "Synthesis of two novel C-19 analogues of (±)-alstoscholarisine A", volume = "84", number = "9", pages = "935-941", doi = "10.2298/JSC190212026B" }
Bihelović, F., Ferjančić, Z.,& Jončev, Z.. (2019). Synthesis of two novel C-19 analogues of (±)-alstoscholarisine A. in Journal of the Serbian Chemical Society Beograd : Srpsko hemijsko društvo., 84(9), 935-941. https://doi.org/10.2298/JSC190212026B
Bihelović F, Ferjančić Z, Jončev Z. Synthesis of two novel C-19 analogues of (±)-alstoscholarisine A. in Journal of the Serbian Chemical Society. 2019;84(9):935-941. doi:10.2298/JSC190212026B .
Bihelović, Filip, Ferjančić, Zorana, Jončev, Zlatko, "Synthesis of two novel C-19 analogues of (±)-alstoscholarisine A" in Journal of the Serbian Chemical Society, 84, no. 9 (2019):935-941, https://doi.org/10.2298/JSC190212026B . .