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Changes of isoenzymes of serum N-acetyl-beta-glucosaminidase in relation to different types of diabetes
dc.creator | Mandić, Ljuba M. | |
dc.creator | Filipović, Dragana | |
dc.date.accessioned | 2018-11-22T00:02:13Z | |
dc.date.available | 2018-11-22T00:02:13Z | |
dc.date.issued | 1998 | |
dc.identifier.issn | 1039-9712 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/382 | |
dc.description.abstract | The activity of the isoenzymes of N-acetyl-beta-D-glucosaminidase (NAG, EC 3.2.1.30) is determined in the serum of insulin-dependent (IDDM) and non insulin-dependent diabetics (NIDDM) with or without diabetic complications. The increase in total activity of serum NAG in diabetics is proportional to the A form activity (r=0,976, p lt 0,0001). The contribution of the A form activity (65.87+/-5.99%) to total NAG activity of IDDM and NIDDM diabetics with and without complications does not change considerably compared to the control group. The contribution of the B form activity depends on the state of metabolic monitoring and diabetic complications. A significantly lower activity of the serum B form was found in IDDM (p lt 0,001) and NIDDM diabetics (p lt 0,05) compared to the healthy individuals, as well as the higher activity ratios of the A/B forms. A decrease in serum B form is correlated with the occurrence and abundance of the intermediary I forms (r=-0,665). These changes are particularly significant in the individuals with the pronounced microangiopathy. | en |
dc.publisher | Academic Press Aust, Marrickville | |
dc.rights | restrictedAccess | |
dc.source | Biochemistry and Molecular Biology International | |
dc.subject | N-acetyl-beta-D-glucosaminidase | en |
dc.subject | isoenzymes | en |
dc.subject | isoenzyme activity ratio A/B | en |
dc.subject | insulin-dependent and non-insulin-dependent diabetes | en |
dc.subject | diabetic complications | en |
dc.title | Changes of isoenzymes of serum N-acetyl-beta-glucosaminidase in relation to different types of diabetes | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Мандић, Љуба М.; Филиповиц, Д; | |
dc.citation.volume | 45 | |
dc.citation.issue | 3 | |
dc.citation.spage | 545 | |
dc.citation.epage | 554 | |
dc.identifier.wos | 000074892100013 | |
dc.citation.other | 45(3): 545-554 | |
dc.citation.rank | M23 | |
dc.identifier.pmid | 9679655 | |
dc.type.version | publishedVersion | en |
dc.identifier.scopus | 2-s2.0-0031873077 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_cherry_382 |
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