Modern and traditional extraction techniques affect chemical composition and bioactivity of Tanacetum parthenium (L.) Sch.Bip
Samo za registrovane korisnike
2020
Autori
Zengin, GokhanCvetanović, Aleksandra
Gašić, Uroš M.
Stupar, Alena
Bulut, Gizem
Şenkardes, Ismail
Dogan, Ahmet
Ibrahime Sinan, Kouadio
Uysal, Sengul
Aumeeruddy-Elalfi, Zaahira
Aktumsek, Abdurrahman
Fawzi Mahomoodally, Mohamad
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Tanacetum parthenium (L.) Sch.Bip (TP), a flowering plant, is famous in traditional medicine to prevent migraine and headache. However, there is currently a dearth of studies to advocate the phytochemical profile and biological propensities of extracts prepared from this plant. This study endeavors to highlight the biological potential of TP extracts prepared by modern (ultrasound-UAE, microwave-MAE and accelerated-ASE extractions) and traditional (maceration and Soxhlet) extraction techniques. The chemical profile of the extracts was established via ultra-high-pressure liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) technique. Sixty different polyphenolic compounds belonging to the classes of phenolic acids, flavonoid glycosides and flavonoid aglycones were recorded in the extracts. Additionally, the quantity of 17 components was measured using appropriate standards and it was found that the modern extraction gave extracts with the higher content of observed compounds tha...n the traditional techniques. Evaluation of antioxidant activity was determined in vitro via five standard assays. The inhibitory potential of TP extracts against key enzymes implicated in the non-communicable diseases such as diabetes (α-amylase and α-glucosidase), neurodegenerative diseases (acetyl- and butyrylcholinesterase) and skin diseases (tyrosinase), was assessed. Potent antioxidant ability of all TP extract was revealed with a predominance for the extracts yielded using the ASE method. This potent antioxidant activity of the extracts corroborated with the high phenolic (65.05 ± 0.27 mg gallic acid equivalent (GAE)/g extract) and flavonoid contents (55.40 ± 0.52 mg rutin equivalent (RE)/g extract). Tanacetum parthenium extracts also showed significant α-glucosidase inhibitory activity (1.63–1.67 mmol acarbose equivalent (ACAE)/g extract) and moderate inhibition activity against α-amylase (0.51-0.56 mmol ACAE/g extract). The extracts also showed potent activity against cholinesterases and tyrosinase. This study tend to validate the use of TP extracts obtained by novel extraction techniques such as ASE, as potent bioactive extracts to be further studied for therapeutic bio-product development.
Ključne reči:
Antioxidant / Feverfew / Novel agents / Phenolics / PhytochemicalsIzvor:
Industrial Crops and Products, 2020, 146Izdavač:
- Elsevier
Finansiranje / projekti:
- This work was partly supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia.
Napomena:
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/3893
DOI: 10.1016/j.indcrop.2020.112202
ISSN: 0926-6690
WoS: 000519335100011
Scopus: 2-s2.0-85079195628
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Zengin, Gokhan AU - Cvetanović, Aleksandra AU - Gašić, Uroš M. AU - Stupar, Alena AU - Bulut, Gizem AU - Şenkardes, Ismail AU - Dogan, Ahmet AU - Ibrahime Sinan, Kouadio AU - Uysal, Sengul AU - Aumeeruddy-Elalfi, Zaahira AU - Aktumsek, Abdurrahman AU - Fawzi Mahomoodally, Mohamad PY - 2020 UR - https://cherry.chem.bg.ac.rs/handle/123456789/3882 AB - Tanacetum parthenium (L.) Sch.Bip (TP), a flowering plant, is famous in traditional medicine to prevent migraine and headache. However, there is currently a dearth of studies to advocate the phytochemical profile and biological propensities of extracts prepared from this plant. This study endeavors to highlight the biological potential of TP extracts prepared by modern (ultrasound-UAE, microwave-MAE and accelerated-ASE extractions) and traditional (maceration and Soxhlet) extraction techniques. The chemical profile of the extracts was established via ultra-high-pressure liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) technique. Sixty different polyphenolic compounds belonging to the classes of phenolic acids, flavonoid glycosides and flavonoid aglycones were recorded in the extracts. Additionally, the quantity of 17 components was measured using appropriate standards and it was found that the modern extraction gave extracts with the higher content of observed compounds than the traditional techniques. Evaluation of antioxidant activity was determined in vitro via five standard assays. The inhibitory potential of TP extracts against key enzymes implicated in the non-communicable diseases such as diabetes (α-amylase and α-glucosidase), neurodegenerative diseases (acetyl- and butyrylcholinesterase) and skin diseases (tyrosinase), was assessed. Potent antioxidant ability of all TP extract was revealed with a predominance for the extracts yielded using the ASE method. This potent antioxidant activity of the extracts corroborated with the high phenolic (65.05 ± 0.27 mg gallic acid equivalent (GAE)/g extract) and flavonoid contents (55.40 ± 0.52 mg rutin equivalent (RE)/g extract). Tanacetum parthenium extracts also showed significant α-glucosidase inhibitory activity (1.63–1.67 mmol acarbose equivalent (ACAE)/g extract) and moderate inhibition activity against α-amylase (0.51-0.56 mmol ACAE/g extract). The extracts also showed potent activity against cholinesterases and tyrosinase. This study tend to validate the use of TP extracts obtained by novel extraction techniques such as ASE, as potent bioactive extracts to be further studied for therapeutic bio-product development. PB - Elsevier T2 - Industrial Crops and Products T1 - Modern and traditional extraction techniques affect chemical composition and bioactivity of Tanacetum parthenium (L.) Sch.Bip VL - 146 DO - 10.1016/j.indcrop.2020.112202 ER -
@article{ author = "Zengin, Gokhan and Cvetanović, Aleksandra and Gašić, Uroš M. and Stupar, Alena and Bulut, Gizem and Şenkardes, Ismail and Dogan, Ahmet and Ibrahime Sinan, Kouadio and Uysal, Sengul and Aumeeruddy-Elalfi, Zaahira and Aktumsek, Abdurrahman and Fawzi Mahomoodally, Mohamad", year = "2020", abstract = "Tanacetum parthenium (L.) Sch.Bip (TP), a flowering plant, is famous in traditional medicine to prevent migraine and headache. However, there is currently a dearth of studies to advocate the phytochemical profile and biological propensities of extracts prepared from this plant. This study endeavors to highlight the biological potential of TP extracts prepared by modern (ultrasound-UAE, microwave-MAE and accelerated-ASE extractions) and traditional (maceration and Soxhlet) extraction techniques. The chemical profile of the extracts was established via ultra-high-pressure liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) technique. Sixty different polyphenolic compounds belonging to the classes of phenolic acids, flavonoid glycosides and flavonoid aglycones were recorded in the extracts. Additionally, the quantity of 17 components was measured using appropriate standards and it was found that the modern extraction gave extracts with the higher content of observed compounds than the traditional techniques. Evaluation of antioxidant activity was determined in vitro via five standard assays. The inhibitory potential of TP extracts against key enzymes implicated in the non-communicable diseases such as diabetes (α-amylase and α-glucosidase), neurodegenerative diseases (acetyl- and butyrylcholinesterase) and skin diseases (tyrosinase), was assessed. Potent antioxidant ability of all TP extract was revealed with a predominance for the extracts yielded using the ASE method. This potent antioxidant activity of the extracts corroborated with the high phenolic (65.05 ± 0.27 mg gallic acid equivalent (GAE)/g extract) and flavonoid contents (55.40 ± 0.52 mg rutin equivalent (RE)/g extract). Tanacetum parthenium extracts also showed significant α-glucosidase inhibitory activity (1.63–1.67 mmol acarbose equivalent (ACAE)/g extract) and moderate inhibition activity against α-amylase (0.51-0.56 mmol ACAE/g extract). The extracts also showed potent activity against cholinesterases and tyrosinase. This study tend to validate the use of TP extracts obtained by novel extraction techniques such as ASE, as potent bioactive extracts to be further studied for therapeutic bio-product development.", publisher = "Elsevier", journal = "Industrial Crops and Products", title = "Modern and traditional extraction techniques affect chemical composition and bioactivity of Tanacetum parthenium (L.) Sch.Bip", volume = "146", doi = "10.1016/j.indcrop.2020.112202" }
Zengin, G., Cvetanović, A., Gašić, U. M., Stupar, A., Bulut, G., Şenkardes, I., Dogan, A., Ibrahime Sinan, K., Uysal, S., Aumeeruddy-Elalfi, Z., Aktumsek, A.,& Fawzi Mahomoodally, M.. (2020). Modern and traditional extraction techniques affect chemical composition and bioactivity of Tanacetum parthenium (L.) Sch.Bip. in Industrial Crops and Products Elsevier., 146. https://doi.org/10.1016/j.indcrop.2020.112202
Zengin G, Cvetanović A, Gašić UM, Stupar A, Bulut G, Şenkardes I, Dogan A, Ibrahime Sinan K, Uysal S, Aumeeruddy-Elalfi Z, Aktumsek A, Fawzi Mahomoodally M. Modern and traditional extraction techniques affect chemical composition and bioactivity of Tanacetum parthenium (L.) Sch.Bip. in Industrial Crops and Products. 2020;146. doi:10.1016/j.indcrop.2020.112202 .
Zengin, Gokhan, Cvetanović, Aleksandra, Gašić, Uroš M., Stupar, Alena, Bulut, Gizem, Şenkardes, Ismail, Dogan, Ahmet, Ibrahime Sinan, Kouadio, Uysal, Sengul, Aumeeruddy-Elalfi, Zaahira, Aktumsek, Abdurrahman, Fawzi Mahomoodally, Mohamad, "Modern and traditional extraction techniques affect chemical composition and bioactivity of Tanacetum parthenium (L.) Sch.Bip" in Industrial Crops and Products, 146 (2020), https://doi.org/10.1016/j.indcrop.2020.112202 . .