A comparative exploration of the phytochemical profiles and bio-pharmaceutical potential of Helichrysum stoechas subsp. barrelieri extracts obtained via five extraction techniques
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2020
Authors
Zengin, GokhanCvetanović, Aleksandra
Gašić, Uroš M.
Tešić, Živoslav Lj.
Stupar, Alena
Bulut, Gizem
Sinan, Kouadio Ibrahime
Uysal, Sengul
Picot-Allain, Marie Carene Nancy
Mahomoodally, Mohamad Fawzi
Article (Published version)
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We endeavoured to probe into and compare the possible effect(s) of different extraction techniques (accelerated solvent extraction (ASE), microwave-assisted extraction (MAE), ultrasonication-assisted extraction (UAE), maceration, and Soxhlet extraction (SE)) on the bioactivity (antioxidant and enzyme inhibitory activities) of the aerial parts of Helichrysum stoechas subsp. barrelieri (Ten.) Nyman. Total phenolic and flavonoid contents of the extracts obtained by different extraction methods followed the order of ASE > MAE > UAE > maceration > SE. Extract obtained by ASE was the most potent radical scavenger (219.92 and 313.12 mg Trolox equivalent [TE]/g, against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), respectively) and reducing agent (927.39 and 662.87 mg TE/g, for cupric reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP), respectively). Helichrysum stoechas extract obtained by UAE (18.67 m...g ethylenediaminetetraacetic equivalent [EDTAE]/g) was the most active metal chelator and inhibitor of acetylcholinesterase (4.23 mg galantamine equivalent [GALAE]/g) and butyrylcholinesterase (6.05 mg GALAE/g) cholinesterase. Extract from maceration (183.32 mg kojic acid equivalent [KAE]/g) was most active against tyrosinase while ASE extract (1.66 mmol acarbose equivalent [ACAE]/g) effectively inhibited α-glucosidase. In conclusion, data amassed herein tend to advocate for the use of non-conventional extraction techniques, namely ASE and UAE, for the extraction of bioactive secondary metabolites from H. stoechas aerial parts.
Keywords:
Antioxidant / Bioactive products / Enzyme inhibition / Helichrysum stoechas / Multivariate analysisSource:
Process Biochemistry, 2020, 91, 113-125Publisher:
- Elsevier
Note:
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/3965
- Peer-reviewed manuscript: http://cherry.chem.bg.ac.rs/handle/123456789/3964
DOI: 10.1016/j.procbio.2019.12.002
ISSN: 1359-5113
WoS: 000526117900013
Scopus: 2-s2.0-85076488515
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Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Zengin, Gokhan AU - Cvetanović, Aleksandra AU - Gašić, Uroš M. AU - Tešić, Živoslav Lj. AU - Stupar, Alena AU - Bulut, Gizem AU - Sinan, Kouadio Ibrahime AU - Uysal, Sengul AU - Picot-Allain, Marie Carene Nancy AU - Mahomoodally, Mohamad Fawzi PY - 2020 UR - https://cherry.chem.bg.ac.rs/handle/123456789/3963 AB - We endeavoured to probe into and compare the possible effect(s) of different extraction techniques (accelerated solvent extraction (ASE), microwave-assisted extraction (MAE), ultrasonication-assisted extraction (UAE), maceration, and Soxhlet extraction (SE)) on the bioactivity (antioxidant and enzyme inhibitory activities) of the aerial parts of Helichrysum stoechas subsp. barrelieri (Ten.) Nyman. Total phenolic and flavonoid contents of the extracts obtained by different extraction methods followed the order of ASE > MAE > UAE > maceration > SE. Extract obtained by ASE was the most potent radical scavenger (219.92 and 313.12 mg Trolox equivalent [TE]/g, against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), respectively) and reducing agent (927.39 and 662.87 mg TE/g, for cupric reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP), respectively). Helichrysum stoechas extract obtained by UAE (18.67 mg ethylenediaminetetraacetic equivalent [EDTAE]/g) was the most active metal chelator and inhibitor of acetylcholinesterase (4.23 mg galantamine equivalent [GALAE]/g) and butyrylcholinesterase (6.05 mg GALAE/g) cholinesterase. Extract from maceration (183.32 mg kojic acid equivalent [KAE]/g) was most active against tyrosinase while ASE extract (1.66 mmol acarbose equivalent [ACAE]/g) effectively inhibited α-glucosidase. In conclusion, data amassed herein tend to advocate for the use of non-conventional extraction techniques, namely ASE and UAE, for the extraction of bioactive secondary metabolites from H. stoechas aerial parts. PB - Elsevier T2 - Process Biochemistry T1 - A comparative exploration of the phytochemical profiles and bio-pharmaceutical potential of Helichrysum stoechas subsp. barrelieri extracts obtained via five extraction techniques VL - 91 SP - 113 EP - 125 DO - 10.1016/j.procbio.2019.12.002 ER -
@article{ author = "Zengin, Gokhan and Cvetanović, Aleksandra and Gašić, Uroš M. and Tešić, Živoslav Lj. and Stupar, Alena and Bulut, Gizem and Sinan, Kouadio Ibrahime and Uysal, Sengul and Picot-Allain, Marie Carene Nancy and Mahomoodally, Mohamad Fawzi", year = "2020", abstract = "We endeavoured to probe into and compare the possible effect(s) of different extraction techniques (accelerated solvent extraction (ASE), microwave-assisted extraction (MAE), ultrasonication-assisted extraction (UAE), maceration, and Soxhlet extraction (SE)) on the bioactivity (antioxidant and enzyme inhibitory activities) of the aerial parts of Helichrysum stoechas subsp. barrelieri (Ten.) Nyman. Total phenolic and flavonoid contents of the extracts obtained by different extraction methods followed the order of ASE > MAE > UAE > maceration > SE. Extract obtained by ASE was the most potent radical scavenger (219.92 and 313.12 mg Trolox equivalent [TE]/g, against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), respectively) and reducing agent (927.39 and 662.87 mg TE/g, for cupric reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP), respectively). Helichrysum stoechas extract obtained by UAE (18.67 mg ethylenediaminetetraacetic equivalent [EDTAE]/g) was the most active metal chelator and inhibitor of acetylcholinesterase (4.23 mg galantamine equivalent [GALAE]/g) and butyrylcholinesterase (6.05 mg GALAE/g) cholinesterase. Extract from maceration (183.32 mg kojic acid equivalent [KAE]/g) was most active against tyrosinase while ASE extract (1.66 mmol acarbose equivalent [ACAE]/g) effectively inhibited α-glucosidase. In conclusion, data amassed herein tend to advocate for the use of non-conventional extraction techniques, namely ASE and UAE, for the extraction of bioactive secondary metabolites from H. stoechas aerial parts.", publisher = "Elsevier", journal = "Process Biochemistry", title = "A comparative exploration of the phytochemical profiles and bio-pharmaceutical potential of Helichrysum stoechas subsp. barrelieri extracts obtained via five extraction techniques", volume = "91", pages = "113-125", doi = "10.1016/j.procbio.2019.12.002" }
Zengin, G., Cvetanović, A., Gašić, U. M., Tešić, Ž. Lj., Stupar, A., Bulut, G., Sinan, K. I., Uysal, S., Picot-Allain, M. C. N.,& Mahomoodally, M. F.. (2020). A comparative exploration of the phytochemical profiles and bio-pharmaceutical potential of Helichrysum stoechas subsp. barrelieri extracts obtained via five extraction techniques. in Process Biochemistry Elsevier., 91, 113-125. https://doi.org/10.1016/j.procbio.2019.12.002
Zengin G, Cvetanović A, Gašić UM, Tešić ŽL, Stupar A, Bulut G, Sinan KI, Uysal S, Picot-Allain MCN, Mahomoodally MF. A comparative exploration of the phytochemical profiles and bio-pharmaceutical potential of Helichrysum stoechas subsp. barrelieri extracts obtained via five extraction techniques. in Process Biochemistry. 2020;91:113-125. doi:10.1016/j.procbio.2019.12.002 .
Zengin, Gokhan, Cvetanović, Aleksandra, Gašić, Uroš M., Tešić, Živoslav Lj., Stupar, Alena, Bulut, Gizem, Sinan, Kouadio Ibrahime, Uysal, Sengul, Picot-Allain, Marie Carene Nancy, Mahomoodally, Mohamad Fawzi, "A comparative exploration of the phytochemical profiles and bio-pharmaceutical potential of Helichrysum stoechas subsp. barrelieri extracts obtained via five extraction techniques" in Process Biochemistry, 91 (2020):113-125, https://doi.org/10.1016/j.procbio.2019.12.002 . .