The preparation of an isoxazole derivative of 4-hydroxycoumarin
Апстракт
A method for preparation of an isoxazole derivative of 4-hydroxycoumarin, 3-phenyl-5-(4-hydroxy-3-coumarinyl)-isoxazole has been described. The reaction sequence includes addition of bromine to 3-cinnamoyl-4-hydroxycoumarin, and the subsequent treatment of the obtained dibromo derivative with 2 equivalents of sodium azide. Due to steric reasons, the azido group is introduced in the beta-position with respect to the side chain carbonyl group, so that an isoxazole ring can be formed. The total yield of the reaction was 58%.
Кључне речи:
4-hydroxycoumarin / isoxazole / azidovinyl ketonesИзвор:
Journal of the Serbian Chemical Society, 1998, 63, 11, 841-844Издавач:
- Serbian Chemical Soc, Belgrade
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Krstic, L AU - Solujic, S AU - Sukdolak, S AU - Stefanović, Milutin AU - Sladić, Dušan PY - 1998 UR - https://cherry.chem.bg.ac.rs/handle/123456789/398 AB - A method for preparation of an isoxazole derivative of 4-hydroxycoumarin, 3-phenyl-5-(4-hydroxy-3-coumarinyl)-isoxazole has been described. The reaction sequence includes addition of bromine to 3-cinnamoyl-4-hydroxycoumarin, and the subsequent treatment of the obtained dibromo derivative with 2 equivalents of sodium azide. Due to steric reasons, the azido group is introduced in the beta-position with respect to the side chain carbonyl group, so that an isoxazole ring can be formed. The total yield of the reaction was 58%. PB - Serbian Chemical Soc, Belgrade T2 - Journal of the Serbian Chemical Society T1 - The preparation of an isoxazole derivative of 4-hydroxycoumarin VL - 63 IS - 11 SP - 841 EP - 844 UR - https://hdl.handle.net/21.15107/rcub_cherry_398 ER -
@article{ author = "Krstic, L and Solujic, S and Sukdolak, S and Stefanović, Milutin and Sladić, Dušan", year = "1998", abstract = "A method for preparation of an isoxazole derivative of 4-hydroxycoumarin, 3-phenyl-5-(4-hydroxy-3-coumarinyl)-isoxazole has been described. The reaction sequence includes addition of bromine to 3-cinnamoyl-4-hydroxycoumarin, and the subsequent treatment of the obtained dibromo derivative with 2 equivalents of sodium azide. Due to steric reasons, the azido group is introduced in the beta-position with respect to the side chain carbonyl group, so that an isoxazole ring can be formed. The total yield of the reaction was 58%.", publisher = "Serbian Chemical Soc, Belgrade", journal = "Journal of the Serbian Chemical Society", title = "The preparation of an isoxazole derivative of 4-hydroxycoumarin", volume = "63", number = "11", pages = "841-844", url = "https://hdl.handle.net/21.15107/rcub_cherry_398" }
Krstic, L., Solujic, S., Sukdolak, S., Stefanović, M.,& Sladić, D.. (1998). The preparation of an isoxazole derivative of 4-hydroxycoumarin. in Journal of the Serbian Chemical Society Serbian Chemical Soc, Belgrade., 63(11), 841-844. https://hdl.handle.net/21.15107/rcub_cherry_398
Krstic L, Solujic S, Sukdolak S, Stefanović M, Sladić D. The preparation of an isoxazole derivative of 4-hydroxycoumarin. in Journal of the Serbian Chemical Society. 1998;63(11):841-844. https://hdl.handle.net/21.15107/rcub_cherry_398 .
Krstic, L, Solujic, S, Sukdolak, S, Stefanović, Milutin, Sladić, Dušan, "The preparation of an isoxazole derivative of 4-hydroxycoumarin" in Journal of the Serbian Chemical Society, 63, no. 11 (1998):841-844, https://hdl.handle.net/21.15107/rcub_cherry_398 .