Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy
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Conventional chemotherapy is the most common therapeutic method for treating cancer by the application of small toxic molecules thatinteract with DNA and causecell death. Unfortunately, these chemotherapeutic agents are non-selective and can damage both cancer and healthy tissues, producing diverse side effects, andthey can have a short circulation half-life and limited targeting. Many synthetic polymers have found application as nanocarriers of intelligent drug delivery systems (DDSs). Their unique physicochemical properties allow them to carry drugs with high efficiency, specificallytarget cancer tissue and control drug release. In recent years, considerable efforts have been made to design smart nanoplatforms, including amphiphilic block copolymers, polymer-drug conjugates and in particular pH- and redox-stimuli-responsive nanoparticles (NPs). This review is focused on a new generation of polymer-based DDSs with specific chemical functionalities that improve their hydrophilicity, dr...ug loading and cellular interactions.Recentlydesigned multifunctional DDSs used in cancer therapy are highlighted in this review.
Keywords:
block copolymers / cancer therapy / polymer-drug conjugates / polymeric nanocarriersSource:
Pharmaceutics, 2020, 12, 4, 298-Funding / projects:
- Studies of enzyme interactions with toxic and pharmacologically active molecules (RS-MESTD-Basic Research (BR or ON)-172023)
- Novel encapsulation and enzyme technologies for designing of new biocatalysts and biologically active compounds targeting enhancement of food quality, safety and competitiveness (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46010)
DOI: 10.3390/pharmaceutics12040298
ISSN: 1999-4923
WoS: 000535575000003
Scopus: 2-s2.0-85082853469
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Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Avramović, Nataša AU - Mandić, Boris AU - Savić-Radojević, Ana AU - Simić, Tatjana PY - 2020 UR - https://www.mdpi.com/1999-4923/12/4/298 UR - https://cherry.chem.bg.ac.rs/handle/123456789/4021 AB - Conventional chemotherapy is the most common therapeutic method for treating cancer by the application of small toxic molecules thatinteract with DNA and causecell death. Unfortunately, these chemotherapeutic agents are non-selective and can damage both cancer and healthy tissues, producing diverse side effects, andthey can have a short circulation half-life and limited targeting. Many synthetic polymers have found application as nanocarriers of intelligent drug delivery systems (DDSs). Their unique physicochemical properties allow them to carry drugs with high efficiency, specificallytarget cancer tissue and control drug release. In recent years, considerable efforts have been made to design smart nanoplatforms, including amphiphilic block copolymers, polymer-drug conjugates and in particular pH- and redox-stimuli-responsive nanoparticles (NPs). This review is focused on a new generation of polymer-based DDSs with specific chemical functionalities that improve their hydrophilicity, drug loading and cellular interactions.Recentlydesigned multifunctional DDSs used in cancer therapy are highlighted in this review. T2 - Pharmaceutics T2 - Pharmaceutics T1 - Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy VL - 12 IS - 4 SP - 298 DO - 10.3390/pharmaceutics12040298 ER -
@article{ author = "Avramović, Nataša and Mandić, Boris and Savić-Radojević, Ana and Simić, Tatjana", year = "2020", abstract = "Conventional chemotherapy is the most common therapeutic method for treating cancer by the application of small toxic molecules thatinteract with DNA and causecell death. Unfortunately, these chemotherapeutic agents are non-selective and can damage both cancer and healthy tissues, producing diverse side effects, andthey can have a short circulation half-life and limited targeting. Many synthetic polymers have found application as nanocarriers of intelligent drug delivery systems (DDSs). Their unique physicochemical properties allow them to carry drugs with high efficiency, specificallytarget cancer tissue and control drug release. In recent years, considerable efforts have been made to design smart nanoplatforms, including amphiphilic block copolymers, polymer-drug conjugates and in particular pH- and redox-stimuli-responsive nanoparticles (NPs). This review is focused on a new generation of polymer-based DDSs with specific chemical functionalities that improve their hydrophilicity, drug loading and cellular interactions.Recentlydesigned multifunctional DDSs used in cancer therapy are highlighted in this review.", journal = "Pharmaceutics, Pharmaceutics", title = "Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy", volume = "12", number = "4", pages = "298", doi = "10.3390/pharmaceutics12040298" }
Avramović, N., Mandić, B., Savić-Radojević, A.,& Simić, T.. (2020). Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy. in Pharmaceutics, 12(4), 298. https://doi.org/10.3390/pharmaceutics12040298
Avramović N, Mandić B, Savić-Radojević A, Simić T. Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy. in Pharmaceutics. 2020;12(4):298. doi:10.3390/pharmaceutics12040298 .
Avramović, Nataša, Mandić, Boris, Savić-Radojević, Ana, Simić, Tatjana, "Polymeric Nanocarriers of Drug Delivery Systems in Cancer Therapy" in Pharmaceutics, 12, no. 4 (2020):298, https://doi.org/10.3390/pharmaceutics12040298 . .