Significance of arsenic and lead in Hashimoto's thyroiditis demonstrated on thyroid tissue, blood, and urine samples
Само за регистроване кориснике
2020
Аутори
Stojsavljević, AleksandarRovčanin, Branislav
Jagodić, Jovana
Drašković Radojković, Danijela
Paunović, Ivan
Gavrović-Jankulović, Marija
Manojlović, Dragan D.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Our previous investigation showed significantly increased arsenic (As) content in thyroid tissue samples of patients with Hashimoto's thyroiditis (HT). This research aimed to extend previous findings and provide reliable insight into the close relationship between As and other trace elements with HT by considering a greater number of thyroid tissue samples, accompanied by blood and urine samples. The essential trace elements for thyroid homeostasis (Mn, Cu, Zn, Se) and the main threatening toxic trace elements (Ni, As, Pb, Cd, U) was analyzed by inductively coupled plasma-mass spectrometry (ICP-MS). Relevant parameters that could affect the concentration of trace elements were considered. This research showed that there was a difference in the elemental profile between HT and control samples. The most important findings were related to the elevated As and Pb content in the thyroid tissue and HT blood samples. The obtained negative correlations between As and Pb with Se may explain the ...antagonistic effect of As and Pb on the extrusion of essential Se from the HT tissue. The reduced Se content in the blood and its increased content in urine samples may further confirm this hypothesis and explain the lack of Se in HT. Furthermore, the reported results may highlight the unresolved molecular basis of HT and could indicate the role of trace element effects on thyroid homeostasis.
Кључне речи:
Arsenic (As) / Hashimoto's thyroiditis / Lead (Pb) / Selenium (Se) / Toxic/ essential trace elementsИзвор:
Environmental Research, 2020, 186, 109538-Издавач:
- Elsevier
Финансирање / пројекти:
- Примена унапређених оксидационих процеса и наноструктурисаних оксидних материјала за уклањање загађивача из животне средине, развој и оптимизација инструменталних техника за праћење ефикасности (RS-MESTD-Basic Research (BR or ON)-172030)
DOI: 10.1016/j.envres.2020.109538
ISSN: 0013-9351
WoS: 000548186300069
Scopus: 2-s2.0-85083432390
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Stojsavljević, Aleksandar AU - Rovčanin, Branislav AU - Jagodić, Jovana AU - Drašković Radojković, Danijela AU - Paunović, Ivan AU - Gavrović-Jankulović, Marija AU - Manojlović, Dragan D. PY - 2020 UR - https://cherry.chem.bg.ac.rs/handle/123456789/4032 AB - Our previous investigation showed significantly increased arsenic (As) content in thyroid tissue samples of patients with Hashimoto's thyroiditis (HT). This research aimed to extend previous findings and provide reliable insight into the close relationship between As and other trace elements with HT by considering a greater number of thyroid tissue samples, accompanied by blood and urine samples. The essential trace elements for thyroid homeostasis (Mn, Cu, Zn, Se) and the main threatening toxic trace elements (Ni, As, Pb, Cd, U) was analyzed by inductively coupled plasma-mass spectrometry (ICP-MS). Relevant parameters that could affect the concentration of trace elements were considered. This research showed that there was a difference in the elemental profile between HT and control samples. The most important findings were related to the elevated As and Pb content in the thyroid tissue and HT blood samples. The obtained negative correlations between As and Pb with Se may explain the antagonistic effect of As and Pb on the extrusion of essential Se from the HT tissue. The reduced Se content in the blood and its increased content in urine samples may further confirm this hypothesis and explain the lack of Se in HT. Furthermore, the reported results may highlight the unresolved molecular basis of HT and could indicate the role of trace element effects on thyroid homeostasis. PB - Elsevier T2 - Environmental Research T1 - Significance of arsenic and lead in Hashimoto's thyroiditis demonstrated on thyroid tissue, blood, and urine samples VL - 186 SP - 109538 DO - 10.1016/j.envres.2020.109538 ER -
@article{ author = "Stojsavljević, Aleksandar and Rovčanin, Branislav and Jagodić, Jovana and Drašković Radojković, Danijela and Paunović, Ivan and Gavrović-Jankulović, Marija and Manojlović, Dragan D.", year = "2020", abstract = "Our previous investigation showed significantly increased arsenic (As) content in thyroid tissue samples of patients with Hashimoto's thyroiditis (HT). This research aimed to extend previous findings and provide reliable insight into the close relationship between As and other trace elements with HT by considering a greater number of thyroid tissue samples, accompanied by blood and urine samples. The essential trace elements for thyroid homeostasis (Mn, Cu, Zn, Se) and the main threatening toxic trace elements (Ni, As, Pb, Cd, U) was analyzed by inductively coupled plasma-mass spectrometry (ICP-MS). Relevant parameters that could affect the concentration of trace elements were considered. This research showed that there was a difference in the elemental profile between HT and control samples. The most important findings were related to the elevated As and Pb content in the thyroid tissue and HT blood samples. The obtained negative correlations between As and Pb with Se may explain the antagonistic effect of As and Pb on the extrusion of essential Se from the HT tissue. The reduced Se content in the blood and its increased content in urine samples may further confirm this hypothesis and explain the lack of Se in HT. Furthermore, the reported results may highlight the unresolved molecular basis of HT and could indicate the role of trace element effects on thyroid homeostasis.", publisher = "Elsevier", journal = "Environmental Research", title = "Significance of arsenic and lead in Hashimoto's thyroiditis demonstrated on thyroid tissue, blood, and urine samples", volume = "186", pages = "109538", doi = "10.1016/j.envres.2020.109538" }
Stojsavljević, A., Rovčanin, B., Jagodić, J., Drašković Radojković, D., Paunović, I., Gavrović-Jankulović, M.,& Manojlović, D. D.. (2020). Significance of arsenic and lead in Hashimoto's thyroiditis demonstrated on thyroid tissue, blood, and urine samples. in Environmental Research Elsevier., 186, 109538. https://doi.org/10.1016/j.envres.2020.109538
Stojsavljević A, Rovčanin B, Jagodić J, Drašković Radojković D, Paunović I, Gavrović-Jankulović M, Manojlović DD. Significance of arsenic and lead in Hashimoto's thyroiditis demonstrated on thyroid tissue, blood, and urine samples. in Environmental Research. 2020;186:109538. doi:10.1016/j.envres.2020.109538 .
Stojsavljević, Aleksandar, Rovčanin, Branislav, Jagodić, Jovana, Drašković Radojković, Danijela, Paunović, Ivan, Gavrović-Jankulović, Marija, Manojlović, Dragan D., "Significance of arsenic and lead in Hashimoto's thyroiditis demonstrated on thyroid tissue, blood, and urine samples" in Environmental Research, 186 (2020):109538, https://doi.org/10.1016/j.envres.2020.109538 . .