Higher environmental temperature potentiates cataleptic effect of fentanyl in rats
Samo za registrovane korisnike
1998
Autori
Vuckovic, SIvanović, Milovan
Prostran, M
Todorović, Zoran B.
Ristovic, Z
Micovic, I
Beleslin, D.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The influence of higher environmental temperature (HET=30+/-1 degrees C) on fentanyl-induced behavior was studied in unrestrained rats. Subacute exposure (3 days) of rats to HET significantly (P lt 0.01) increased the cataleptic effect of fentanyl citrate (0.5 mg/kg), in comparison to the corresponding exposure to normal environmental temperature (NET=22+/-1 degrees C). Also, the hyperthermic response of rats to a low dose of fentanyl citrate (0.2-0.5 mg/kg) was significantly (P lt 0.01) potentiated, and the hypothermic response to a high dose of fentanyl citrate (1.5 mg/kg) was significantly (P lt 0.05) attenuated after exposure to HET. Fentanyl-induced hyperexcitability, loss of righting reflex, loss of corneal reflex and analgesia were not significantly affected by HET. This study provides the first evidence on the influence of environmental temperature on drug-induced catalepsy. MET-induced potentiation of the cataleptic response to fentanyl could be the result of an interference... with behavioral thermoregulation.
Ključne reči:
fentanyl / behavior / environmental temperatureIzvor:
Japanese Journal of Pharmacology, 1998, 78, 4, 523-527Izdavač:
- Japanese Pharmacological Soc, Kyoto
Napomena:
- Free full text: https://doi.org/10.1254/jjp.78.523
DOI: 10.1254/jjp.78.523
ISSN: 0021-5198
PubMed: 9920213
WoS: 000077704400019
Scopus: 2-s2.0-0032421381
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Vuckovic, S AU - Ivanović, Milovan AU - Prostran, M AU - Todorović, Zoran B. AU - Ristovic, Z AU - Micovic, I AU - Beleslin, D. PY - 1998 UR - https://cherry.chem.bg.ac.rs/handle/123456789/403 AB - The influence of higher environmental temperature (HET=30+/-1 degrees C) on fentanyl-induced behavior was studied in unrestrained rats. Subacute exposure (3 days) of rats to HET significantly (P lt 0.01) increased the cataleptic effect of fentanyl citrate (0.5 mg/kg), in comparison to the corresponding exposure to normal environmental temperature (NET=22+/-1 degrees C). Also, the hyperthermic response of rats to a low dose of fentanyl citrate (0.2-0.5 mg/kg) was significantly (P lt 0.01) potentiated, and the hypothermic response to a high dose of fentanyl citrate (1.5 mg/kg) was significantly (P lt 0.05) attenuated after exposure to HET. Fentanyl-induced hyperexcitability, loss of righting reflex, loss of corneal reflex and analgesia were not significantly affected by HET. This study provides the first evidence on the influence of environmental temperature on drug-induced catalepsy. MET-induced potentiation of the cataleptic response to fentanyl could be the result of an interference with behavioral thermoregulation. PB - Japanese Pharmacological Soc, Kyoto T2 - Japanese Journal of Pharmacology T1 - Higher environmental temperature potentiates cataleptic effect of fentanyl in rats VL - 78 IS - 4 SP - 523 EP - 527 DO - 10.1254/jjp.78.523 ER -
@article{ author = "Vuckovic, S and Ivanović, Milovan and Prostran, M and Todorović, Zoran B. and Ristovic, Z and Micovic, I and Beleslin, D.", year = "1998", abstract = "The influence of higher environmental temperature (HET=30+/-1 degrees C) on fentanyl-induced behavior was studied in unrestrained rats. Subacute exposure (3 days) of rats to HET significantly (P lt 0.01) increased the cataleptic effect of fentanyl citrate (0.5 mg/kg), in comparison to the corresponding exposure to normal environmental temperature (NET=22+/-1 degrees C). Also, the hyperthermic response of rats to a low dose of fentanyl citrate (0.2-0.5 mg/kg) was significantly (P lt 0.01) potentiated, and the hypothermic response to a high dose of fentanyl citrate (1.5 mg/kg) was significantly (P lt 0.05) attenuated after exposure to HET. Fentanyl-induced hyperexcitability, loss of righting reflex, loss of corneal reflex and analgesia were not significantly affected by HET. This study provides the first evidence on the influence of environmental temperature on drug-induced catalepsy. MET-induced potentiation of the cataleptic response to fentanyl could be the result of an interference with behavioral thermoregulation.", publisher = "Japanese Pharmacological Soc, Kyoto", journal = "Japanese Journal of Pharmacology", title = "Higher environmental temperature potentiates cataleptic effect of fentanyl in rats", volume = "78", number = "4", pages = "523-527", doi = "10.1254/jjp.78.523" }
Vuckovic, S., Ivanović, M., Prostran, M., Todorović, Z. B., Ristovic, Z., Micovic, I.,& Beleslin, D.. (1998). Higher environmental temperature potentiates cataleptic effect of fentanyl in rats. in Japanese Journal of Pharmacology Japanese Pharmacological Soc, Kyoto., 78(4), 523-527. https://doi.org/10.1254/jjp.78.523
Vuckovic S, Ivanović M, Prostran M, Todorović ZB, Ristovic Z, Micovic I, Beleslin D. Higher environmental temperature potentiates cataleptic effect of fentanyl in rats. in Japanese Journal of Pharmacology. 1998;78(4):523-527. doi:10.1254/jjp.78.523 .
Vuckovic, S, Ivanović, Milovan, Prostran, M, Todorović, Zoran B., Ristovic, Z, Micovic, I, Beleslin, D., "Higher environmental temperature potentiates cataleptic effect of fentanyl in rats" in Japanese Journal of Pharmacology, 78, no. 4 (1998):523-527, https://doi.org/10.1254/jjp.78.523 . .