Polyphenols as Possible Agents for Pancreatic Diseases
Аутори
Gašić, Uroš M.Ćirić, Ivanka
Pejčić, Tomislav
Radenković, Dejan
Đorđević, Vladimir
Radulović, Siniša
Tešić, Živoslav Lj.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Pancreatic cancer (PC) is very aggressive and it is estimated that it kills nearly 50% of patients within the first six months. The lack of symptoms specific to this disease prevents early diagnosis and treatment. Today, gemcitabine alone or in combination with other cytostatic agents such as cisplatin (Cis), 5-fluorouracil (5-FU), irinotecan, capecitabine, or oxaliplatin (Oxa) is used in conventional therapy. Outgoing literature provides data on the use of polyphenols, biologically active compounds, in the treatment of pancreatic cancer and the prevention of acute pancreatitis. Therefore, the first part of this review gives a brief overview of the state of pancreatic disease as well as the procedures for its treatment. The second part provides a detailed overview of the research regarding the anticancer effects of both pure polyphenols and their plant extracts. The results regarding the antiproliferative, antimetastatic, as well as inhibitory effects of polyphenols against PC cell lin...es as well as the prevention of acute pancreatitis are presented in detail. Finally, particular emphasis is given to the polyphenolic profiles of apples, berries, cherries, sour cherries, and grapes, given the fact that these fruits are rich in polyphenols and anthocyanins. Polyphenolic profiles, the content of individual polyphenols, and their relationships are discussed. Based on this, significant data can be obtained regarding the amount of fruit that should be consumed daily to achieve a therapeutic effect.
Кључне речи:
pancreatic diseases / polyphenol bioavailability / polyphenols / quercetin / resveratrol / synergistic effectsИзвор:
Antioxidants, 2020, 9, 6, 547-Издавач:
- MDPI
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200288 (Иновациони центар Хемијског факултета у Београду доо) (RS-MESTD-inst-2020-200288)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200168 (Универзитет у Београду, Хемијски факултет) (RS-MESTD-inst-2020-200168)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-MESTD-inst-2020-200007)
DOI: 10.3390/antiox9060547
ISSN: 2076-3921
WoS: 000551230800001
Scopus: 2-s2.0-85090686538
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Gašić, Uroš M. AU - Ćirić, Ivanka AU - Pejčić, Tomislav AU - Radenković, Dejan AU - Đorđević, Vladimir AU - Radulović, Siniša AU - Tešić, Živoslav Lj. PY - 2020 UR - https://cherry.chem.bg.ac.rs/handle/123456789/4080 AB - Pancreatic cancer (PC) is very aggressive and it is estimated that it kills nearly 50% of patients within the first six months. The lack of symptoms specific to this disease prevents early diagnosis and treatment. Today, gemcitabine alone or in combination with other cytostatic agents such as cisplatin (Cis), 5-fluorouracil (5-FU), irinotecan, capecitabine, or oxaliplatin (Oxa) is used in conventional therapy. Outgoing literature provides data on the use of polyphenols, biologically active compounds, in the treatment of pancreatic cancer and the prevention of acute pancreatitis. Therefore, the first part of this review gives a brief overview of the state of pancreatic disease as well as the procedures for its treatment. The second part provides a detailed overview of the research regarding the anticancer effects of both pure polyphenols and their plant extracts. The results regarding the antiproliferative, antimetastatic, as well as inhibitory effects of polyphenols against PC cell lines as well as the prevention of acute pancreatitis are presented in detail. Finally, particular emphasis is given to the polyphenolic profiles of apples, berries, cherries, sour cherries, and grapes, given the fact that these fruits are rich in polyphenols and anthocyanins. Polyphenolic profiles, the content of individual polyphenols, and their relationships are discussed. Based on this, significant data can be obtained regarding the amount of fruit that should be consumed daily to achieve a therapeutic effect. PB - MDPI T2 - Antioxidants T1 - Polyphenols as Possible Agents for Pancreatic Diseases VL - 9 IS - 6 SP - 547 DO - 10.3390/antiox9060547 ER -
@article{ author = "Gašić, Uroš M. and Ćirić, Ivanka and Pejčić, Tomislav and Radenković, Dejan and Đorđević, Vladimir and Radulović, Siniša and Tešić, Živoslav Lj.", year = "2020", abstract = "Pancreatic cancer (PC) is very aggressive and it is estimated that it kills nearly 50% of patients within the first six months. The lack of symptoms specific to this disease prevents early diagnosis and treatment. Today, gemcitabine alone or in combination with other cytostatic agents such as cisplatin (Cis), 5-fluorouracil (5-FU), irinotecan, capecitabine, or oxaliplatin (Oxa) is used in conventional therapy. Outgoing literature provides data on the use of polyphenols, biologically active compounds, in the treatment of pancreatic cancer and the prevention of acute pancreatitis. Therefore, the first part of this review gives a brief overview of the state of pancreatic disease as well as the procedures for its treatment. The second part provides a detailed overview of the research regarding the anticancer effects of both pure polyphenols and their plant extracts. The results regarding the antiproliferative, antimetastatic, as well as inhibitory effects of polyphenols against PC cell lines as well as the prevention of acute pancreatitis are presented in detail. Finally, particular emphasis is given to the polyphenolic profiles of apples, berries, cherries, sour cherries, and grapes, given the fact that these fruits are rich in polyphenols and anthocyanins. Polyphenolic profiles, the content of individual polyphenols, and their relationships are discussed. Based on this, significant data can be obtained regarding the amount of fruit that should be consumed daily to achieve a therapeutic effect.", publisher = "MDPI", journal = "Antioxidants", title = "Polyphenols as Possible Agents for Pancreatic Diseases", volume = "9", number = "6", pages = "547", doi = "10.3390/antiox9060547" }
Gašić, U. M., Ćirić, I., Pejčić, T., Radenković, D., Đorđević, V., Radulović, S.,& Tešić, Ž. Lj.. (2020). Polyphenols as Possible Agents for Pancreatic Diseases. in Antioxidants MDPI., 9(6), 547. https://doi.org/10.3390/antiox9060547
Gašić UM, Ćirić I, Pejčić T, Radenković D, Đorđević V, Radulović S, Tešić ŽL. Polyphenols as Possible Agents for Pancreatic Diseases. in Antioxidants. 2020;9(6):547. doi:10.3390/antiox9060547 .
Gašić, Uroš M., Ćirić, Ivanka, Pejčić, Tomislav, Radenković, Dejan, Đorđević, Vladimir, Radulović, Siniša, Tešić, Živoslav Lj., "Polyphenols as Possible Agents for Pancreatic Diseases" in Antioxidants, 9, no. 6 (2020):547, https://doi.org/10.3390/antiox9060547 . .