Cobalt(II), Zinc(II), Iron(III), and Copper(II) Complexes Bearing Positively Charged Quaternary Ammonium Functionalities: Synthesis, Characterization, Electrochemical Behavior, and SOD Activity
Аутори
Stojičkov, MarkoSturm, Sabrina
Čobeljić, Božidar
Pevec, Andrej
Jevtović, Mima
Scheitler, Andreas
Radanović, Dušanka D.
Senft, Laura
Turel, Iztok
Anđelković, Katarina K.
Miehlich, Matthias
Meyer, Karsten
Ivanović-Burmazović, Ivana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
We have synthesized and characterized Co(II) (1), Zn(II) (2), Fe(III) (3) and Cu(II) (4) complexes of 2,2'‐[2,6‐pyridinediylbis(ethylidyne‐1‐hydrazinyl‐2‐ylidene)]bis[N,N,N‐trimethyl‐2‐oxoethanaminium] dichloride (H2LCl2) by NMR, IR, and X‐Band EPR spectroscopy, respectively, as well as by single‐crystal X‐ray structural analysis. H2LCl2 belongs to the class of diacetylpyridine bis(hydrazone) ligands and bears two positively charged quaternary ammonium functionalities. The complexes 1–3 possess a pentagonal‐bipyramidal geometry, whereas 4 has square‐pyramidal geometry. Redox reactivity and SOD activity of the complexes was studied by means of electrochemical measurements in aqueous‐buffer and DMF or DMSO solutions, respectively, as well as by stopped‐flow measurements. Complexes 1–3 do not have SOD activity, whereas 4 exhibits a high catalytic rate constant for the superoxide dismutation, kcat = 1.73 × 107 m–1 s–1 (in MOPS buffer solution of pH = 7.4). The results were discussed in ter...ms of complex redox potentials, electrostatic interactions and their spatial distribution, kinetic lability of metal centers, and stability of peroxo intermediates, respectively.
Кључне речи:
Cobalt / Copper / Electrochemistry / Iron / SOD activity / Structure elucidationИзвор:
European Journal of Inorganic Chemistry, 2020, 3347-3358Издавач:
- Wiley-VCH Verlag
Финансирање / пројекти:
- Интеракције природних производа, њихових деривата и комплексних једињења са протеинима и нуклеинским киселинама (RS-MESTD-Basic Research (BR or ON)-172055)
- Slovenian Research Agency (ARRS) through program P‐0175
- ERASMUS + program
- DFG (IV 80/13‐1 project)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200026 (Универзитет у Београду, Институт за хемију, технологију и металургију - ИХТМ) (RS-MESTD-inst-2020-200026)
DOI: 10.1002/ejic.202000415
ISSN: 1099-0682
WoS: 000564577200001
Scopus: 2-s2.0-85090058906
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Stojičkov, Marko AU - Sturm, Sabrina AU - Čobeljić, Božidar AU - Pevec, Andrej AU - Jevtović, Mima AU - Scheitler, Andreas AU - Radanović, Dušanka D. AU - Senft, Laura AU - Turel, Iztok AU - Anđelković, Katarina K. AU - Miehlich, Matthias AU - Meyer, Karsten AU - Ivanović-Burmazović, Ivana PY - 2020 UR - https://cherry.chem.bg.ac.rs/handle/123456789/4285 AB - We have synthesized and characterized Co(II) (1), Zn(II) (2), Fe(III) (3) and Cu(II) (4) complexes of 2,2'‐[2,6‐pyridinediylbis(ethylidyne‐1‐hydrazinyl‐2‐ylidene)]bis[N,N,N‐trimethyl‐2‐oxoethanaminium] dichloride (H2LCl2) by NMR, IR, and X‐Band EPR spectroscopy, respectively, as well as by single‐crystal X‐ray structural analysis. H2LCl2 belongs to the class of diacetylpyridine bis(hydrazone) ligands and bears two positively charged quaternary ammonium functionalities. The complexes 1–3 possess a pentagonal‐bipyramidal geometry, whereas 4 has square‐pyramidal geometry. Redox reactivity and SOD activity of the complexes was studied by means of electrochemical measurements in aqueous‐buffer and DMF or DMSO solutions, respectively, as well as by stopped‐flow measurements. Complexes 1–3 do not have SOD activity, whereas 4 exhibits a high catalytic rate constant for the superoxide dismutation, kcat = 1.73 × 107 m–1 s–1 (in MOPS buffer solution of pH = 7.4). The results were discussed in terms of complex redox potentials, electrostatic interactions and their spatial distribution, kinetic lability of metal centers, and stability of peroxo intermediates, respectively. PB - Wiley-VCH Verlag T2 - European Journal of Inorganic Chemistry T1 - Cobalt(II), Zinc(II), Iron(III), and Copper(II) Complexes Bearing Positively Charged Quaternary Ammonium Functionalities: Synthesis, Characterization, Electrochemical Behavior, and SOD Activity SP - 3347 EP - 3358 DO - 10.1002/ejic.202000415 ER -
@article{ author = "Stojičkov, Marko and Sturm, Sabrina and Čobeljić, Božidar and Pevec, Andrej and Jevtović, Mima and Scheitler, Andreas and Radanović, Dušanka D. and Senft, Laura and Turel, Iztok and Anđelković, Katarina K. and Miehlich, Matthias and Meyer, Karsten and Ivanović-Burmazović, Ivana", year = "2020", abstract = "We have synthesized and characterized Co(II) (1), Zn(II) (2), Fe(III) (3) and Cu(II) (4) complexes of 2,2'‐[2,6‐pyridinediylbis(ethylidyne‐1‐hydrazinyl‐2‐ylidene)]bis[N,N,N‐trimethyl‐2‐oxoethanaminium] dichloride (H2LCl2) by NMR, IR, and X‐Band EPR spectroscopy, respectively, as well as by single‐crystal X‐ray structural analysis. H2LCl2 belongs to the class of diacetylpyridine bis(hydrazone) ligands and bears two positively charged quaternary ammonium functionalities. The complexes 1–3 possess a pentagonal‐bipyramidal geometry, whereas 4 has square‐pyramidal geometry. Redox reactivity and SOD activity of the complexes was studied by means of electrochemical measurements in aqueous‐buffer and DMF or DMSO solutions, respectively, as well as by stopped‐flow measurements. Complexes 1–3 do not have SOD activity, whereas 4 exhibits a high catalytic rate constant for the superoxide dismutation, kcat = 1.73 × 107 m–1 s–1 (in MOPS buffer solution of pH = 7.4). The results were discussed in terms of complex redox potentials, electrostatic interactions and their spatial distribution, kinetic lability of metal centers, and stability of peroxo intermediates, respectively.", publisher = "Wiley-VCH Verlag", journal = "European Journal of Inorganic Chemistry", title = "Cobalt(II), Zinc(II), Iron(III), and Copper(II) Complexes Bearing Positively Charged Quaternary Ammonium Functionalities: Synthesis, Characterization, Electrochemical Behavior, and SOD Activity", pages = "3347-3358", doi = "10.1002/ejic.202000415" }
Stojičkov, M., Sturm, S., Čobeljić, B., Pevec, A., Jevtović, M., Scheitler, A., Radanović, D. D., Senft, L., Turel, I., Anđelković, K. K., Miehlich, M., Meyer, K.,& Ivanović-Burmazović, I.. (2020). Cobalt(II), Zinc(II), Iron(III), and Copper(II) Complexes Bearing Positively Charged Quaternary Ammonium Functionalities: Synthesis, Characterization, Electrochemical Behavior, and SOD Activity. in European Journal of Inorganic Chemistry Wiley-VCH Verlag., 3347-3358. https://doi.org/10.1002/ejic.202000415
Stojičkov M, Sturm S, Čobeljić B, Pevec A, Jevtović M, Scheitler A, Radanović DD, Senft L, Turel I, Anđelković KK, Miehlich M, Meyer K, Ivanović-Burmazović I. Cobalt(II), Zinc(II), Iron(III), and Copper(II) Complexes Bearing Positively Charged Quaternary Ammonium Functionalities: Synthesis, Characterization, Electrochemical Behavior, and SOD Activity. in European Journal of Inorganic Chemistry. 2020;:3347-3358. doi:10.1002/ejic.202000415 .
Stojičkov, Marko, Sturm, Sabrina, Čobeljić, Božidar, Pevec, Andrej, Jevtović, Mima, Scheitler, Andreas, Radanović, Dušanka D., Senft, Laura, Turel, Iztok, Anđelković, Katarina K., Miehlich, Matthias, Meyer, Karsten, Ivanović-Burmazović, Ivana, "Cobalt(II), Zinc(II), Iron(III), and Copper(II) Complexes Bearing Positively Charged Quaternary Ammonium Functionalities: Synthesis, Characterization, Electrochemical Behavior, and SOD Activity" in European Journal of Inorganic Chemistry (2020):3347-3358, https://doi.org/10.1002/ejic.202000415 . .