Evaluation of DNA/BSA interactions and DFT calculations of gold(III), zinc(II) and palladium(II) complexes with triammonium N-dithiocarboxyiminodiacetate
Само за регистроване кориснике
2021
Аутори
Kasalović, Marijana P.Petrović, Angelina
Živković, Jelena M.
Kuckling, Linus
Jevtić, Verica V.
Bogojeski, Jovana
Leka, Zorica B.
Trifunović, Srećko R.
Pantelić, Nebojša Đ.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Dithiocarbamates, with their high lipophilic character and good chelating properties, could provide stabile transition metal complexes and enable these metal-based drugs to reach their biological targets. Palladium(II) and gold(III) complexes, due to its structural similarity with platinum(II)compounds, could be competitive candidates for implementing and developing new pharmacological agents. Herein, novel gold(III) complex with triammonium N-carboxyiminodiacetate as ligand has been synthesized and characterized by elemental analysis, molar conductivity measurements, FT-IR and 1H and 13C NMR spectroscopy. The proposed structure was examined and compared with analogue palladium(II) and zinc(II) complexes by density functional theory (B3LYP/def2tzvp). Additionally, DNA-binding studies by UV/Vis-spectrometer as well as ethidium-bromide (EB) and bovine serum albumin (BSA) quenching studies by spectrofluorometer were performed for gold(III), palladium(II) and zinc(II) dithiocarbamate compl...exes. The investigated complexes showed a good affinity to calf thymus DNA (CT-DNA) and BSA, with a higher affinity to BSA. Palladium(II) complex exhibited 5-fold a stronger affinity to DNA binding in comparison to zinc(II), but no significantly higher than gold(III) complex. Furthermore, palladium(II) and gold(III) complexes demonstrated a similar affinity toward BSA and these interactions are stronger than showed by zinc(II) complex.
Кључне речи:
DFT calculations / Dithiocarbamate / DNA/BSA interactions / Metal complexesИзвор:
Journal of Molecular Structure, 2021, 1229, 129622-Издавач:
- Elsevier
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200122 (Универзитет у Крагујевцу, Природно-математички факултет) (RS-200122)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200116 (Универзитет у Београду, Пољопривредни факултет) (RS-200116)
- Bilateral project between Republic of Serbia and Montenegro [01-3103].
Напомена:
- Supplementary material: https://cherry.chem.bg.ac.rs/handle/123456789/4438
Повезане информације:
DOI: 10.1016/j.molstruc.2020.129622
ISSN: 0022-2860
WoS: 000619138300010
Scopus: 2-s2.0-85096144173
Колекције
Институција/група
Inovacioni centar / Innovation CentreTY - JOUR AU - Kasalović, Marijana P. AU - Petrović, Angelina AU - Živković, Jelena M. AU - Kuckling, Linus AU - Jevtić, Verica V. AU - Bogojeski, Jovana AU - Leka, Zorica B. AU - Trifunović, Srećko R. AU - Pantelić, Nebojša Đ. PY - 2021 UR - https://cherry.chem.bg.ac.rs/handle/123456789/4436 AB - Dithiocarbamates, with their high lipophilic character and good chelating properties, could provide stabile transition metal complexes and enable these metal-based drugs to reach their biological targets. Palladium(II) and gold(III) complexes, due to its structural similarity with platinum(II)compounds, could be competitive candidates for implementing and developing new pharmacological agents. Herein, novel gold(III) complex with triammonium N-carboxyiminodiacetate as ligand has been synthesized and characterized by elemental analysis, molar conductivity measurements, FT-IR and 1H and 13C NMR spectroscopy. The proposed structure was examined and compared with analogue palladium(II) and zinc(II) complexes by density functional theory (B3LYP/def2tzvp). Additionally, DNA-binding studies by UV/Vis-spectrometer as well as ethidium-bromide (EB) and bovine serum albumin (BSA) quenching studies by spectrofluorometer were performed for gold(III), palladium(II) and zinc(II) dithiocarbamate complexes. The investigated complexes showed a good affinity to calf thymus DNA (CT-DNA) and BSA, with a higher affinity to BSA. Palladium(II) complex exhibited 5-fold a stronger affinity to DNA binding in comparison to zinc(II), but no significantly higher than gold(III) complex. Furthermore, palladium(II) and gold(III) complexes demonstrated a similar affinity toward BSA and these interactions are stronger than showed by zinc(II) complex. PB - Elsevier T2 - Journal of Molecular Structure T1 - Evaluation of DNA/BSA interactions and DFT calculations of gold(III), zinc(II) and palladium(II) complexes with triammonium N-dithiocarboxyiminodiacetate VL - 1229 SP - 129622 DO - 10.1016/j.molstruc.2020.129622 ER -
@article{ author = "Kasalović, Marijana P. and Petrović, Angelina and Živković, Jelena M. and Kuckling, Linus and Jevtić, Verica V. and Bogojeski, Jovana and Leka, Zorica B. and Trifunović, Srećko R. and Pantelić, Nebojša Đ.", year = "2021", abstract = "Dithiocarbamates, with their high lipophilic character and good chelating properties, could provide stabile transition metal complexes and enable these metal-based drugs to reach their biological targets. Palladium(II) and gold(III) complexes, due to its structural similarity with platinum(II)compounds, could be competitive candidates for implementing and developing new pharmacological agents. Herein, novel gold(III) complex with triammonium N-carboxyiminodiacetate as ligand has been synthesized and characterized by elemental analysis, molar conductivity measurements, FT-IR and 1H and 13C NMR spectroscopy. The proposed structure was examined and compared with analogue palladium(II) and zinc(II) complexes by density functional theory (B3LYP/def2tzvp). Additionally, DNA-binding studies by UV/Vis-spectrometer as well as ethidium-bromide (EB) and bovine serum albumin (BSA) quenching studies by spectrofluorometer were performed for gold(III), palladium(II) and zinc(II) dithiocarbamate complexes. The investigated complexes showed a good affinity to calf thymus DNA (CT-DNA) and BSA, with a higher affinity to BSA. Palladium(II) complex exhibited 5-fold a stronger affinity to DNA binding in comparison to zinc(II), but no significantly higher than gold(III) complex. Furthermore, palladium(II) and gold(III) complexes demonstrated a similar affinity toward BSA and these interactions are stronger than showed by zinc(II) complex.", publisher = "Elsevier", journal = "Journal of Molecular Structure", title = "Evaluation of DNA/BSA interactions and DFT calculations of gold(III), zinc(II) and palladium(II) complexes with triammonium N-dithiocarboxyiminodiacetate", volume = "1229", pages = "129622", doi = "10.1016/j.molstruc.2020.129622" }
Kasalović, M. P., Petrović, A., Živković, J. M., Kuckling, L., Jevtić, V. V., Bogojeski, J., Leka, Z. B., Trifunović, S. R.,& Pantelić, N. Đ.. (2021). Evaluation of DNA/BSA interactions and DFT calculations of gold(III), zinc(II) and palladium(II) complexes with triammonium N-dithiocarboxyiminodiacetate. in Journal of Molecular Structure Elsevier., 1229, 129622. https://doi.org/10.1016/j.molstruc.2020.129622
Kasalović MP, Petrović A, Živković JM, Kuckling L, Jevtić VV, Bogojeski J, Leka ZB, Trifunović SR, Pantelić NĐ. Evaluation of DNA/BSA interactions and DFT calculations of gold(III), zinc(II) and palladium(II) complexes with triammonium N-dithiocarboxyiminodiacetate. in Journal of Molecular Structure. 2021;1229:129622. doi:10.1016/j.molstruc.2020.129622 .
Kasalović, Marijana P., Petrović, Angelina, Živković, Jelena M., Kuckling, Linus, Jevtić, Verica V., Bogojeski, Jovana, Leka, Zorica B., Trifunović, Srećko R., Pantelić, Nebojša Đ., "Evaluation of DNA/BSA interactions and DFT calculations of gold(III), zinc(II) and palladium(II) complexes with triammonium N-dithiocarboxyiminodiacetate" in Journal of Molecular Structure, 1229 (2021):129622, https://doi.org/10.1016/j.molstruc.2020.129622 . .