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Screen printed diamond electrode as efficient “point-of-care” platform for submicromolar determination of cytostatic drug in biological fluids and pharmaceutical product
dc.creator | Stanković, Dalibor | |
dc.creator | Milanović, Zorana | |
dc.creator | Švorc, Ljubomir | |
dc.creator | Stanković, Vesna | |
dc.creator | Janković, Drina | |
dc.creator | Mirković, Marija D. | |
dc.creator | Vranješ-Đurić, Sanja | |
dc.date.accessioned | 2021-07-12T10:24:19Z | |
dc.date.available | 2021-07-12T10:24:19Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0925-9635 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0925963521000406 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/4450 | |
dc.description.abstract | This work presents advanced electrochemical platform based on screen printed diamond electrode (SPDE) system for the single drop “point-of-care” testing. Proposed approach was applied for the quantification of doxorubicin hydrochloride (DOX) in biological fluids and pharmaceutical product. Using a single drop (~30 μL) of the tested solution at the electrode surface, DOX showed high electroactivity over a wide range of pHs. In these conditions, single oval shaped, well-defined and pH dependent oxidation peak was observed in the potential range from 0.5 V to 1.3 V. In the reverse scan, two cathodic peaks, were noted – around 0.3 V and – 0.5 V. Similarly, first reduction peak was pH dependent, while second one was independent in the studied range. Experimental conditions for DOX quantification were optimized and natures of the electrode reactions were investigated. Working linear range obtained for DOX detection was from 0.1 to 2.5 μM. Diffusion controlled electrode reaction reveal long life time of the proposed electrode as well high potential for practical application. Developed procedure was successfully applied for the DOX analysis in biological fluids – urine and pharmaceutical formulation. Obtained results clearly indicated that given procedure can be easily implemented for pharmaceutical control and medical analysis, in both, laboratory and field conditions. | |
dc.language | en | |
dc.relation | Eureka project E! 13303 MED-BIO-TEST. | |
dc.relation | LˇS wishes to acknowledge the Grant Agency of the Slovak Republic VEGA (grant no. 1/0159/20). | |
dc.rights | restrictedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Diamond and Related Materials | |
dc.subject | “Point-of-care” application | |
dc.subject | Cytostatic drug | |
dc.subject | Screen printed diamond electrode | |
dc.subject | Single drop detection | |
dc.title | Screen printed diamond electrode as efficient “point-of-care” platform for submicromolar determination of cytostatic drug in biological fluids and pharmaceutical product | |
dc.type | article | en |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Врањеш-Ђурић, Сања; Милановић, Зорана; Станковић, Весна; Јанковић, Дрина; Станковић, Далибор; Шворц, Љубомир; Мирковић, Марија Д.; | |
dc.citation.volume | 113 | |
dc.citation.spage | 108277 | |
dc.identifier.wos | 000623246800006 | |
dc.identifier.doi | 10.1016/j.diamond.2021.108277 | |
dc.citation.rank | M22~ | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-85099612809 |