Elemental profiling of adrenal adenomas in solid tissue and blood samples by ICP-MS and ICP-OES
Samo za registrovane korisnike
2021
Autori
Jagodić, JovanaRovčanin, Branislav
Krstić, Đurđa D.
Paunović, Ivan
Živaljević, Vladan
Manojlović, Dragan D.
Stojsavljević, Aleksandar
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The elemental composition of control and pathological adrenal tissues remains to be resolved. This study aimed to provide an initial insight into the amounts of micro- (Mn, Co, Cu, Zn, As, Se, Cd, Pb, U) and macroelements (Na, K, Mg, Ca) in healthy adrenal tissue (HAT) and adenomatous adrenal tissue (AAT) samples collected from patients with adrenal adenoma (AA) using inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma optical emission spectrometry (ICP-OES). The results were accompanied by a comparative determination of the same elements in healthy blood (HB) and adenomatous blood (AB) samples. This is the first study that has provided in-depth knowledge of the baseline composition of the clinically important elements of HAT samples. Furthermore, this study showed elementary changes in AA patients. The AATs had significantly higher amounts of Mn, Cu, Zn, Se, Pb, K, and Mg compared to the HATs. The opposite results were obtained for the same elements in... the AB samples, indicating that the benign adrenal masses could have the ability to withdraw these elements from circulation. These results were supplemented by principal component analysis (PCA). ICP-based techniques were successfully applied to accurately provide a more comprehensive insight into the clinically important elements in the solid tissue and blood samples. The results of this study are a deep-dive into the likely future of clinical studies. Moreover, target elements should be taken into consideration as novel initiating and/or modifying factors of AA, after further research, this would include the analysis of a larger number of samples and prospective follow-up of the patient’s elemental profile.
Ključne reči:
Adrenal adenoma (AA) / ICP-MS and ICP-OES / Microelements/macroelements / PCA / Solid tissue and blood samplesIzvor:
Microchemical Journal, 2021, 165, 106194-Izdavač:
- Elsevier
Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200288 (Inovacioni centar Hemijskog fakulteta u Beogradu doo) (RS-MESTD-inst-2020-200288)
Napomena:
- Supplementary material: https://cherry.chem.bg.ac.rs/handle/123456789/4531
Povezane informacije:
DOI: 10.1016/j.microc.2021.106194
ISSN: 0026-265X
WoS: 000644991500007
Scopus: 2-s2.0-85104958256
URI
https://www.sciencedirect.com/science/article/pii/S0026265X21002782https://cherry.chem.bg.ac.rs/handle/123456789/4530
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Jagodić, Jovana AU - Rovčanin, Branislav AU - Krstić, Đurđa D. AU - Paunović, Ivan AU - Živaljević, Vladan AU - Manojlović, Dragan D. AU - Stojsavljević, Aleksandar PY - 2021 UR - https://www.sciencedirect.com/science/article/pii/S0026265X21002782 UR - https://cherry.chem.bg.ac.rs/handle/123456789/4530 AB - The elemental composition of control and pathological adrenal tissues remains to be resolved. This study aimed to provide an initial insight into the amounts of micro- (Mn, Co, Cu, Zn, As, Se, Cd, Pb, U) and macroelements (Na, K, Mg, Ca) in healthy adrenal tissue (HAT) and adenomatous adrenal tissue (AAT) samples collected from patients with adrenal adenoma (AA) using inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma optical emission spectrometry (ICP-OES). The results were accompanied by a comparative determination of the same elements in healthy blood (HB) and adenomatous blood (AB) samples. This is the first study that has provided in-depth knowledge of the baseline composition of the clinically important elements of HAT samples. Furthermore, this study showed elementary changes in AA patients. The AATs had significantly higher amounts of Mn, Cu, Zn, Se, Pb, K, and Mg compared to the HATs. The opposite results were obtained for the same elements in the AB samples, indicating that the benign adrenal masses could have the ability to withdraw these elements from circulation. These results were supplemented by principal component analysis (PCA). ICP-based techniques were successfully applied to accurately provide a more comprehensive insight into the clinically important elements in the solid tissue and blood samples. The results of this study are a deep-dive into the likely future of clinical studies. Moreover, target elements should be taken into consideration as novel initiating and/or modifying factors of AA, after further research, this would include the analysis of a larger number of samples and prospective follow-up of the patient’s elemental profile. PB - Elsevier T2 - Microchemical Journal T1 - Elemental profiling of adrenal adenomas in solid tissue and blood samples by ICP-MS and ICP-OES VL - 165 SP - 106194 DO - 10.1016/j.microc.2021.106194 ER -
@article{ author = "Jagodić, Jovana and Rovčanin, Branislav and Krstić, Đurđa D. and Paunović, Ivan and Živaljević, Vladan and Manojlović, Dragan D. and Stojsavljević, Aleksandar", year = "2021", abstract = "The elemental composition of control and pathological adrenal tissues remains to be resolved. This study aimed to provide an initial insight into the amounts of micro- (Mn, Co, Cu, Zn, As, Se, Cd, Pb, U) and macroelements (Na, K, Mg, Ca) in healthy adrenal tissue (HAT) and adenomatous adrenal tissue (AAT) samples collected from patients with adrenal adenoma (AA) using inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma optical emission spectrometry (ICP-OES). The results were accompanied by a comparative determination of the same elements in healthy blood (HB) and adenomatous blood (AB) samples. This is the first study that has provided in-depth knowledge of the baseline composition of the clinically important elements of HAT samples. Furthermore, this study showed elementary changes in AA patients. The AATs had significantly higher amounts of Mn, Cu, Zn, Se, Pb, K, and Mg compared to the HATs. The opposite results were obtained for the same elements in the AB samples, indicating that the benign adrenal masses could have the ability to withdraw these elements from circulation. These results were supplemented by principal component analysis (PCA). ICP-based techniques were successfully applied to accurately provide a more comprehensive insight into the clinically important elements in the solid tissue and blood samples. The results of this study are a deep-dive into the likely future of clinical studies. Moreover, target elements should be taken into consideration as novel initiating and/or modifying factors of AA, after further research, this would include the analysis of a larger number of samples and prospective follow-up of the patient’s elemental profile.", publisher = "Elsevier", journal = "Microchemical Journal", title = "Elemental profiling of adrenal adenomas in solid tissue and blood samples by ICP-MS and ICP-OES", volume = "165", pages = "106194", doi = "10.1016/j.microc.2021.106194" }
Jagodić, J., Rovčanin, B., Krstić, Đ. D., Paunović, I., Živaljević, V., Manojlović, D. D.,& Stojsavljević, A.. (2021). Elemental profiling of adrenal adenomas in solid tissue and blood samples by ICP-MS and ICP-OES. in Microchemical Journal Elsevier., 165, 106194. https://doi.org/10.1016/j.microc.2021.106194
Jagodić J, Rovčanin B, Krstić ĐD, Paunović I, Živaljević V, Manojlović DD, Stojsavljević A. Elemental profiling of adrenal adenomas in solid tissue and blood samples by ICP-MS and ICP-OES. in Microchemical Journal. 2021;165:106194. doi:10.1016/j.microc.2021.106194 .
Jagodić, Jovana, Rovčanin, Branislav, Krstić, Đurđa D., Paunović, Ivan, Živaljević, Vladan, Manojlović, Dragan D., Stojsavljević, Aleksandar, "Elemental profiling of adrenal adenomas in solid tissue and blood samples by ICP-MS and ICP-OES" in Microchemical Journal, 165 (2021):106194, https://doi.org/10.1016/j.microc.2021.106194 . .