Antimalarial peroxides: the first intramolecular 1,2,4,5-tetraoxane
Antimalarijski peroksidi - prvi intramolekulski 1,2,4,5-tetraoksan
Abstract
An intramolecular steroidal 1,2,4,5-tetraoxane has been synthesised in six steps starting from methyl 3-oxo-7alpha,12alpha-diacetoxy-5beta-cholan-24-pate. The synthesised 1,2,4,5-tetra-aoxane has moderate in vitro antimalarial activity against P. falciparum Strains (IC50) (D-6) = 0.35 mug/mL: (IC50 (W2) = 0.29 mug/ML).
Polazeći od methyl 3-oxo-7α,12α-diacetoxy-5β-cholan-24-oate sintetisan je u šest faza intramolekulski steroidni 1,2,4,5-tetraoksan. Proizvod ima umerenu in vitro antimalarijsku aktivnost prema P. falciparum sojevima (IC50 (D6) = 0.35 µg/mL; IC50 (W2) = 0.29 µg/mL).
Keywords:
tetraoxane / malaria / malaria / peroxide / peroxide / steroid / steroid / intramolecular / intramolecularSource:
Journal of the Serbian Chemical Society, 2002, 67, 7, 465-471Publisher:
- Serbian Chemical Soc, Belgrade
DOI: 10.2298/JSC0207465O
ISSN: 0352-5139
WoS: 000177384000001
Scopus: 2-s2.0-0036377759
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Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Opsenica, Dejan M. AU - Pocsfalvi, G AU - Milhous, WK AU - Šolaja, Bogdan A. PY - 2002 UR - https://cherry.chem.bg.ac.rs/handle/123456789/502 AB - An intramolecular steroidal 1,2,4,5-tetraoxane has been synthesised in six steps starting from methyl 3-oxo-7alpha,12alpha-diacetoxy-5beta-cholan-24-pate. The synthesised 1,2,4,5-tetra-aoxane has moderate in vitro antimalarial activity against P. falciparum Strains (IC50) (D-6) = 0.35 mug/mL: (IC50 (W2) = 0.29 mug/ML). AB - Polazeći od methyl 3-oxo-7α,12α-diacetoxy-5β-cholan-24-oate sintetisan je u šest faza intramolekulski steroidni 1,2,4,5-tetraoksan. Proizvod ima umerenu in vitro antimalarijsku aktivnost prema P. falciparum sojevima (IC50 (D6) = 0.35 µg/mL; IC50 (W2) = 0.29 µg/mL). PB - Serbian Chemical Soc, Belgrade T2 - Journal of the Serbian Chemical Society T1 - Antimalarial peroxides: the first intramolecular 1,2,4,5-tetraoxane T1 - Antimalarijski peroksidi - prvi intramolekulski 1,2,4,5-tetraoksan VL - 67 IS - 7 SP - 465 EP - 471 DO - 10.2298/JSC0207465O ER -
@article{ author = "Opsenica, Dejan M. and Pocsfalvi, G and Milhous, WK and Šolaja, Bogdan A.", year = "2002", abstract = "An intramolecular steroidal 1,2,4,5-tetraoxane has been synthesised in six steps starting from methyl 3-oxo-7alpha,12alpha-diacetoxy-5beta-cholan-24-pate. The synthesised 1,2,4,5-tetra-aoxane has moderate in vitro antimalarial activity against P. falciparum Strains (IC50) (D-6) = 0.35 mug/mL: (IC50 (W2) = 0.29 mug/ML)., Polazeći od methyl 3-oxo-7α,12α-diacetoxy-5β-cholan-24-oate sintetisan je u šest faza intramolekulski steroidni 1,2,4,5-tetraoksan. Proizvod ima umerenu in vitro antimalarijsku aktivnost prema P. falciparum sojevima (IC50 (D6) = 0.35 µg/mL; IC50 (W2) = 0.29 µg/mL).", publisher = "Serbian Chemical Soc, Belgrade", journal = "Journal of the Serbian Chemical Society", title = "Antimalarial peroxides: the first intramolecular 1,2,4,5-tetraoxane, Antimalarijski peroksidi - prvi intramolekulski 1,2,4,5-tetraoksan", volume = "67", number = "7", pages = "465-471", doi = "10.2298/JSC0207465O" }
Opsenica, D. M., Pocsfalvi, G., Milhous, W.,& Šolaja, B. A.. (2002). Antimalarial peroxides: the first intramolecular 1,2,4,5-tetraoxane. in Journal of the Serbian Chemical Society Serbian Chemical Soc, Belgrade., 67(7), 465-471. https://doi.org/10.2298/JSC0207465O
Opsenica DM, Pocsfalvi G, Milhous W, Šolaja BA. Antimalarial peroxides: the first intramolecular 1,2,4,5-tetraoxane. in Journal of the Serbian Chemical Society. 2002;67(7):465-471. doi:10.2298/JSC0207465O .
Opsenica, Dejan M., Pocsfalvi, G, Milhous, WK, Šolaja, Bogdan A., "Antimalarial peroxides: the first intramolecular 1,2,4,5-tetraoxane" in Journal of the Serbian Chemical Society, 67, no. 7 (2002):465-471, https://doi.org/10.2298/JSC0207465O . .