Salting-out thin-layer chromatography of several myorelaxants
Apstrakt
The chromatographic behavior of five myorelaxant drugs has been studied under the conditions used for salting-out thin-layer chromatography (SOTLC) on cellulose and alumina. For this purpose, aqueous ammonium sulfate solutions of different concentration were used as mobile phases. It was established that hR(F) values always decreased in parallel to increasing salt concentrations. When cellulose was used as adsorbent, a linear relationship was observed between the R-M values and the ammonium sulfate content of the mobile phase. Regression data of the plots obtained were used to determine the lipophilicity parameters R-M(0) and C-0. Lipophilicity determined in this way correlated with calculated log P values.
Ključne reči:
salting-out TLC / myorelaxants / cellulose / aluminaIzvor:
Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography, 2003, 16, 2, 144-146Izdavač:
- Research Inst Medicinal Plants, Budakalasz
DOI: 10.1556/JPC.16.2003.2.11
ISSN: 0933-4173
WoS: 000183519300011
Scopus: 2-s2.0-0038282570
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Aleksic, M AU - Odovic, J AU - Milojković-Opsenica, Dušanka AU - Tešić, Živoslav Lj. PY - 2003 UR - https://cherry.chem.bg.ac.rs/handle/123456789/558 AB - The chromatographic behavior of five myorelaxant drugs has been studied under the conditions used for salting-out thin-layer chromatography (SOTLC) on cellulose and alumina. For this purpose, aqueous ammonium sulfate solutions of different concentration were used as mobile phases. It was established that hR(F) values always decreased in parallel to increasing salt concentrations. When cellulose was used as adsorbent, a linear relationship was observed between the R-M values and the ammonium sulfate content of the mobile phase. Regression data of the plots obtained were used to determine the lipophilicity parameters R-M(0) and C-0. Lipophilicity determined in this way correlated with calculated log P values. PB - Research Inst Medicinal Plants, Budakalasz T2 - Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography T1 - Salting-out thin-layer chromatography of several myorelaxants VL - 16 IS - 2 SP - 144 EP - 146 DO - 10.1556/JPC.16.2003.2.11 ER -
@article{ author = "Aleksic, M and Odovic, J and Milojković-Opsenica, Dušanka and Tešić, Živoslav Lj.", year = "2003", abstract = "The chromatographic behavior of five myorelaxant drugs has been studied under the conditions used for salting-out thin-layer chromatography (SOTLC) on cellulose and alumina. For this purpose, aqueous ammonium sulfate solutions of different concentration were used as mobile phases. It was established that hR(F) values always decreased in parallel to increasing salt concentrations. When cellulose was used as adsorbent, a linear relationship was observed between the R-M values and the ammonium sulfate content of the mobile phase. Regression data of the plots obtained were used to determine the lipophilicity parameters R-M(0) and C-0. Lipophilicity determined in this way correlated with calculated log P values.", publisher = "Research Inst Medicinal Plants, Budakalasz", journal = "Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography", title = "Salting-out thin-layer chromatography of several myorelaxants", volume = "16", number = "2", pages = "144-146", doi = "10.1556/JPC.16.2003.2.11" }
Aleksic, M., Odovic, J., Milojković-Opsenica, D.,& Tešić, Ž. Lj.. (2003). Salting-out thin-layer chromatography of several myorelaxants. in Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography Research Inst Medicinal Plants, Budakalasz., 16(2), 144-146. https://doi.org/10.1556/JPC.16.2003.2.11
Aleksic M, Odovic J, Milojković-Opsenica D, Tešić ŽL. Salting-out thin-layer chromatography of several myorelaxants. in Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography. 2003;16(2):144-146. doi:10.1556/JPC.16.2003.2.11 .
Aleksic, M, Odovic, J, Milojković-Opsenica, Dušanka, Tešić, Živoslav Lj., "Salting-out thin-layer chromatography of several myorelaxants" in Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography, 16, no. 2 (2003):144-146, https://doi.org/10.1556/JPC.16.2003.2.11 . .