Ru(III) complexes derived from N-methyl derivatives of glycine and 1,3-propylenediamine-N,N'-diacetato ligands and their activities against HeLa, K562 cell lines and human PBMC
Abstract
Ruthenium(III) complexes formulated as K2[Ru(sar)Cl4]H2O and K[Ru(dmgly)2Cl2]3H2O containing bidentate chelates N-methylglycine (sarcosine, sar) or N,N-dimethylglycine (dmgly) as well as K[Ru(pdda)Cl2]2.5H2O complex with tetradentate 1,3-propylenediamine-N,N'-diacetato were synthesized. The complexes were obtained by direct reaction of ruthenium(III) chloride with the corresponding bidentate or tetradentate ligand followed by addition of a base (KOH). These new complexes were characterized by elemental analysis, IR and electronic absorption spectroscopy. To assess selectivity in the antitumor action of these complexes, their antiproliferative activities against human adenocarcinoma HeLa cells, human myelogenous leukemia K562 cells, human breast carcinoma MDA-MB-361 and MDA-MB-453 cells and normal immunocompetent PBM cells were determined.
Keywords:
Ruthenium(III) / N / N-dimethylglycine / Sarcosine / 1 / 3-Propylenediamine-N / N'-diacetateSource:
Journal of Coordination Chemistry, 2009, 62, 2, 328-336Publisher:
- Taylor & Francis Ltd, Abingdon
Funding / projects:
- Synthesis, characterization and activity of organic and coordination composition and their application in (bio) nanotechnology (RS-MESTD-MPN2006-2010-142010)
- Istraživanje dejstava modifikatora biološkog odgovora u fiziološkim i patološkim stanjima (RS-MESTD-MPN2006-2010-145006)
DOI: 10.1080/00958970802233128
ISSN: 0095-8972
WoS: 000261765500016
Scopus: 2-s2.0-57749117156
Collections
Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Djinovic, Vesna M. AU - Todorović, Tamara AU - Žižak, Željko S. AU - Sabo, Tibor AU - Juranić, Zorica D. PY - 2009 UR - https://cherry.chem.bg.ac.rs/handle/123456789/591 AB - Ruthenium(III) complexes formulated as K2[Ru(sar)Cl4]H2O and K[Ru(dmgly)2Cl2]3H2O containing bidentate chelates N-methylglycine (sarcosine, sar) or N,N-dimethylglycine (dmgly) as well as K[Ru(pdda)Cl2]2.5H2O complex with tetradentate 1,3-propylenediamine-N,N'-diacetato were synthesized. The complexes were obtained by direct reaction of ruthenium(III) chloride with the corresponding bidentate or tetradentate ligand followed by addition of a base (KOH). These new complexes were characterized by elemental analysis, IR and electronic absorption spectroscopy. To assess selectivity in the antitumor action of these complexes, their antiproliferative activities against human adenocarcinoma HeLa cells, human myelogenous leukemia K562 cells, human breast carcinoma MDA-MB-361 and MDA-MB-453 cells and normal immunocompetent PBM cells were determined. PB - Taylor & Francis Ltd, Abingdon T2 - Journal of Coordination Chemistry T1 - Ru(III) complexes derived from N-methyl derivatives of glycine and 1,3-propylenediamine-N,N'-diacetato ligands and their activities against HeLa, K562 cell lines and human PBMC VL - 62 IS - 2 SP - 328 EP - 336 DO - 10.1080/00958970802233128 ER -
@article{ author = "Djinovic, Vesna M. and Todorović, Tamara and Žižak, Željko S. and Sabo, Tibor and Juranić, Zorica D.", year = "2009", abstract = "Ruthenium(III) complexes formulated as K2[Ru(sar)Cl4]H2O and K[Ru(dmgly)2Cl2]3H2O containing bidentate chelates N-methylglycine (sarcosine, sar) or N,N-dimethylglycine (dmgly) as well as K[Ru(pdda)Cl2]2.5H2O complex with tetradentate 1,3-propylenediamine-N,N'-diacetato were synthesized. The complexes were obtained by direct reaction of ruthenium(III) chloride with the corresponding bidentate or tetradentate ligand followed by addition of a base (KOH). These new complexes were characterized by elemental analysis, IR and electronic absorption spectroscopy. To assess selectivity in the antitumor action of these complexes, their antiproliferative activities against human adenocarcinoma HeLa cells, human myelogenous leukemia K562 cells, human breast carcinoma MDA-MB-361 and MDA-MB-453 cells and normal immunocompetent PBM cells were determined.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Journal of Coordination Chemistry", title = "Ru(III) complexes derived from N-methyl derivatives of glycine and 1,3-propylenediamine-N,N'-diacetato ligands and their activities against HeLa, K562 cell lines and human PBMC", volume = "62", number = "2", pages = "328-336", doi = "10.1080/00958970802233128" }
Djinovic, V. M., Todorović, T., Žižak, Ž. S., Sabo, T.,& Juranić, Z. D.. (2009). Ru(III) complexes derived from N-methyl derivatives of glycine and 1,3-propylenediamine-N,N'-diacetato ligands and their activities against HeLa, K562 cell lines and human PBMC. in Journal of Coordination Chemistry Taylor & Francis Ltd, Abingdon., 62(2), 328-336. https://doi.org/10.1080/00958970802233128
Djinovic VM, Todorović T, Žižak ŽS, Sabo T, Juranić ZD. Ru(III) complexes derived from N-methyl derivatives of glycine and 1,3-propylenediamine-N,N'-diacetato ligands and their activities against HeLa, K562 cell lines and human PBMC. in Journal of Coordination Chemistry. 2009;62(2):328-336. doi:10.1080/00958970802233128 .
Djinovic, Vesna M., Todorović, Tamara, Žižak, Željko S., Sabo, Tibor, Juranić, Zorica D., "Ru(III) complexes derived from N-methyl derivatives of glycine and 1,3-propylenediamine-N,N'-diacetato ligands and their activities against HeLa, K562 cell lines and human PBMC" in Journal of Coordination Chemistry, 62, no. 2 (2009):328-336, https://doi.org/10.1080/00958970802233128 . .