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Synthesis, X-ray diffraction structure, spectroscopic properties and antiproliferative activity of a novel ruthenium complex with constitutional similarity to cisplatin
dc.creator | Grgurić-Šipka, Sanja | |
dc.creator | Stepanenko, Iryna N. | |
dc.creator | Lazić, Jelena | |
dc.creator | Bartel, Caroline | |
dc.creator | Jakupec, Michael A. | |
dc.creator | Arion, Vladimir B. | |
dc.creator | Keppler, Bernhard K. | |
dc.date.accessioned | 2018-11-22T00:14:30Z | |
dc.date.available | 2018-11-22T00:14:30Z | |
dc.date.issued | 2009 | |
dc.identifier.issn | 1477-9226 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/627 | |
dc.description.abstract | The light-protected reaction of [(eta(6)p-cymene)Ru(II)Cl(2)](2) with 1-(2-hydroxyethyl)piperazine in dry methanol, followed by addition of excess NH(4)PF(6), afforded the complex [(eta(6)-p-cymene)Ru(II)(NH(3))(2)Cl]-(PF(6)) (1) in 47% yield. Attempts to use the same protocol for the synthesis of [(eta(6)-pcymene)Os(II)(NH(3))(2)-Cl](PF(6)) led to the isolation of the binuclear triply methoxido-bridged arene-osmium compound [{(eta(6)-p-cymene)Os}(2)(mu-OCH(3))(3)](PF(6)) (3). Both compounds were characterised by X-ray crystallography and (1)H NMR spectroscopy, and the ruthenium complex also by spectroscopic techniques (IR and UV-vis spectroscopies). The antiproliferative activity of complex 1 in vitro was studied in A549 (non-small cell lung carcinoma), CH1 (ovarian carcinoma), and SW480 (colon carcinoma) cells and compared to that of [(eta(6) p-cymene)Ru(II)(en)Cl](PF6) (2). In contrast to the latter compound, 1 is only modestly cytotoxic in all three cell lines (IC(50): 293-542 mu M), probably due to the instability of the diammine ruthenium complex in aqueous solution. | en |
dc.publisher | Royal Soc Chemistry, Cambridge | |
dc.rights | restrictedAccess | |
dc.source | Dalton Transactions | |
dc.title | Synthesis, X-ray diffraction structure, spectroscopic properties and antiproliferative activity of a novel ruthenium complex with constitutional similarity to cisplatin | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Гргурић-Шипка, Сања; Степаненко, Ирyна Н.; Лазиц, Јелена М.; Бартел, Царолине; Јакупец, Мицхаел A.; Aрион, Владимир Б.; Кепплер, Бернхард К.; | |
dc.citation.issue | 17 | |
dc.citation.spage | 3334 | |
dc.citation.epage | 3339 | |
dc.identifier.wos | 000265160700025 | |
dc.identifier.doi | 10.1039/b822725j | |
dc.citation.other | (17): 3334-3339 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 19421637 | |
dc.type.version | publishedVersion | en |
dc.identifier.scopus | 2-s2.0-64549102923 |