Syntheses and activity of some platinum(IV) complexes with N-methyl derivate of glycine and halogeno ligands against HeLa, K562 cell lines and human PBMC
Само за регистроване кориснике
2005
Аутори
Sabo, TiborDinovic, VA
Kaluđerović, Goran N.
Stanojković, Tatjana
Bogdanović, Goran A.
Juranic, ZD
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Four platinum(IV) complexes, trans,trans-dichlorobis(N,N-dimethylglycinato)platinum(IV), trans,trans-[Pt(dmgly)(2)Cl-2] (1) and trans.trans-dibromobis(N,N'-dimethylglycinato)platinum(IV), trans,trans-[Pt(dmgly)(2)Br-2] (2), as well as, trans,trans-dichlorobis(N-methylglycinato)platinum(IV), trans,trans-[Pt(sar)(2)Cl-2] (3) and trans,trans-dibromobis(N-methylglycinato)platinum(IV), trans,trans-[Pt(sar)(2)Br-2] (4) (with configuration index for all complexes OC-6-14), were synthesized and characterized by elemental analysis, infrared and H-1 NMR spectroscopy. In the aim to assess the selectivity in the antitumor action of these complexes, the antiproliferative action of these compounds was determined to human adenocarcinoma HeLa cells; to human myelogenous leukemia K562 cells and to normal immunocompetent cells; i.e., on human PBMC. The details of the crystal structure synthesized trans,trans-[Pt(sar)(2)Br-2] complex were also reported here. In the crystal structure of trans, trans-[Pt(s...ar)(2)Br-2] the Pt(IV) ion had a deformed octahedral coordination with both N-methylglycinates and bromides bonded trans to one another and with the NPt-Br bond angles of 84.1(4) and 95.9(4)degrees. The trans, trans-[Pt(sar)(2)Br-2] complex molecules form 2D-layers with multiple N-H (...) O and C-H (...) O hydrogen bonds. (c) 2005 Elsevier B.V. All rights reserved.
Кључне речи:
platinum (IV) complexes / bidentate ligands / sarcosine / crystal structure / neoplastic cells / PBMCИзвор:
Inorganica Chimica Acta, 2005, 358, 7, 2239-2245Издавач:
- Elsevier Science Sa, Lausanne
DOI: 10.1016/j.ica.2005.01.007
ISSN: 0020-1693
WoS: 000228137700011
Scopus: 2-s2.0-15044361609
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Sabo, Tibor AU - Dinovic, VA AU - Kaluđerović, Goran N. AU - Stanojković, Tatjana AU - Bogdanović, Goran A. AU - Juranic, ZD PY - 2005 UR - https://cherry.chem.bg.ac.rs/handle/123456789/693 AB - Four platinum(IV) complexes, trans,trans-dichlorobis(N,N-dimethylglycinato)platinum(IV), trans,trans-[Pt(dmgly)(2)Cl-2] (1) and trans.trans-dibromobis(N,N'-dimethylglycinato)platinum(IV), trans,trans-[Pt(dmgly)(2)Br-2] (2), as well as, trans,trans-dichlorobis(N-methylglycinato)platinum(IV), trans,trans-[Pt(sar)(2)Cl-2] (3) and trans,trans-dibromobis(N-methylglycinato)platinum(IV), trans,trans-[Pt(sar)(2)Br-2] (4) (with configuration index for all complexes OC-6-14), were synthesized and characterized by elemental analysis, infrared and H-1 NMR spectroscopy. In the aim to assess the selectivity in the antitumor action of these complexes, the antiproliferative action of these compounds was determined to human adenocarcinoma HeLa cells; to human myelogenous leukemia K562 cells and to normal immunocompetent cells; i.e., on human PBMC. The details of the crystal structure synthesized trans,trans-[Pt(sar)(2)Br-2] complex were also reported here. In the crystal structure of trans, trans-[Pt(sar)(2)Br-2] the Pt(IV) ion had a deformed octahedral coordination with both N-methylglycinates and bromides bonded trans to one another and with the NPt-Br bond angles of 84.1(4) and 95.9(4)degrees. The trans, trans-[Pt(sar)(2)Br-2] complex molecules form 2D-layers with multiple N-H (...) O and C-H (...) O hydrogen bonds. (c) 2005 Elsevier B.V. All rights reserved. PB - Elsevier Science Sa, Lausanne T2 - Inorganica Chimica Acta T1 - Syntheses and activity of some platinum(IV) complexes with N-methyl derivate of glycine and halogeno ligands against HeLa, K562 cell lines and human PBMC VL - 358 IS - 7 SP - 2239 EP - 2245 DO - 10.1016/j.ica.2005.01.007 ER -
@article{ author = "Sabo, Tibor and Dinovic, VA and Kaluđerović, Goran N. and Stanojković, Tatjana and Bogdanović, Goran A. and Juranic, ZD", year = "2005", abstract = "Four platinum(IV) complexes, trans,trans-dichlorobis(N,N-dimethylglycinato)platinum(IV), trans,trans-[Pt(dmgly)(2)Cl-2] (1) and trans.trans-dibromobis(N,N'-dimethylglycinato)platinum(IV), trans,trans-[Pt(dmgly)(2)Br-2] (2), as well as, trans,trans-dichlorobis(N-methylglycinato)platinum(IV), trans,trans-[Pt(sar)(2)Cl-2] (3) and trans,trans-dibromobis(N-methylglycinato)platinum(IV), trans,trans-[Pt(sar)(2)Br-2] (4) (with configuration index for all complexes OC-6-14), were synthesized and characterized by elemental analysis, infrared and H-1 NMR spectroscopy. In the aim to assess the selectivity in the antitumor action of these complexes, the antiproliferative action of these compounds was determined to human adenocarcinoma HeLa cells; to human myelogenous leukemia K562 cells and to normal immunocompetent cells; i.e., on human PBMC. The details of the crystal structure synthesized trans,trans-[Pt(sar)(2)Br-2] complex were also reported here. In the crystal structure of trans, trans-[Pt(sar)(2)Br-2] the Pt(IV) ion had a deformed octahedral coordination with both N-methylglycinates and bromides bonded trans to one another and with the NPt-Br bond angles of 84.1(4) and 95.9(4)degrees. The trans, trans-[Pt(sar)(2)Br-2] complex molecules form 2D-layers with multiple N-H (...) O and C-H (...) O hydrogen bonds. (c) 2005 Elsevier B.V. All rights reserved.", publisher = "Elsevier Science Sa, Lausanne", journal = "Inorganica Chimica Acta", title = "Syntheses and activity of some platinum(IV) complexes with N-methyl derivate of glycine and halogeno ligands against HeLa, K562 cell lines and human PBMC", volume = "358", number = "7", pages = "2239-2245", doi = "10.1016/j.ica.2005.01.007" }
Sabo, T., Dinovic, V., Kaluđerović, G. N., Stanojković, T., Bogdanović, G. A.,& Juranic, Z.. (2005). Syntheses and activity of some platinum(IV) complexes with N-methyl derivate of glycine and halogeno ligands against HeLa, K562 cell lines and human PBMC. in Inorganica Chimica Acta Elsevier Science Sa, Lausanne., 358(7), 2239-2245. https://doi.org/10.1016/j.ica.2005.01.007
Sabo T, Dinovic V, Kaluđerović GN, Stanojković T, Bogdanović GA, Juranic Z. Syntheses and activity of some platinum(IV) complexes with N-methyl derivate of glycine and halogeno ligands against HeLa, K562 cell lines and human PBMC. in Inorganica Chimica Acta. 2005;358(7):2239-2245. doi:10.1016/j.ica.2005.01.007 .
Sabo, Tibor, Dinovic, VA, Kaluđerović, Goran N., Stanojković, Tatjana, Bogdanović, Goran A., Juranic, ZD, "Syntheses and activity of some platinum(IV) complexes with N-methyl derivate of glycine and halogeno ligands against HeLa, K562 cell lines and human PBMC" in Inorganica Chimica Acta, 358, no. 7 (2005):2239-2245, https://doi.org/10.1016/j.ica.2005.01.007 . .