Evaluation of the lipophilicity of some 1-arylpiperazines by planar chromatography
Abstract
The lipophilic character of some biologically active 1-arylpiperazines has been studied. A reversed-phase planar chromatographic procedure was established for determination of log Po-w values (n-octanol-water partition coefficients) for the compounds. The compounds were chromatographed with five so-called 'standards' on RP-18 silica plates with methanol-water and dioxane-water binary systems as mobile phases. n-Octanol-water partition coefficients for five standard compounds determined experimentally by use of the shake-flask method were used to obtain the log Po-w values of the 1-arylpiperazines investigated. Experimentally established log Po-w values were compared with log P values calculated by use of five different software packages.
Keywords:
lipophilicity / RP-18 / 1-arylpiperazinesSource:
Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography, 2005, 18, 105, 358-363Publisher:
- Research Inst Medicinal Plants, Budakalasz
DOI: 10.1556/JPC.18.2005.5.4
ISSN: 0933-4173
WoS: 000233095000004
Scopus: 2-s2.0-27944471861
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Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Velickovic, JD AU - Tešić, Živoslav Lj. AU - Milojković-Opsenica, Dušanka PY - 2005 UR - https://cherry.chem.bg.ac.rs/handle/123456789/737 AB - The lipophilic character of some biologically active 1-arylpiperazines has been studied. A reversed-phase planar chromatographic procedure was established for determination of log Po-w values (n-octanol-water partition coefficients) for the compounds. The compounds were chromatographed with five so-called 'standards' on RP-18 silica plates with methanol-water and dioxane-water binary systems as mobile phases. n-Octanol-water partition coefficients for five standard compounds determined experimentally by use of the shake-flask method were used to obtain the log Po-w values of the 1-arylpiperazines investigated. Experimentally established log Po-w values were compared with log P values calculated by use of five different software packages. PB - Research Inst Medicinal Plants, Budakalasz T2 - Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography T1 - Evaluation of the lipophilicity of some 1-arylpiperazines by planar chromatography VL - 18 IS - 105 SP - 358 EP - 363 DO - 10.1556/JPC.18.2005.5.4 ER -
@article{ author = "Velickovic, JD and Tešić, Živoslav Lj. and Milojković-Opsenica, Dušanka", year = "2005", abstract = "The lipophilic character of some biologically active 1-arylpiperazines has been studied. A reversed-phase planar chromatographic procedure was established for determination of log Po-w values (n-octanol-water partition coefficients) for the compounds. The compounds were chromatographed with five so-called 'standards' on RP-18 silica plates with methanol-water and dioxane-water binary systems as mobile phases. n-Octanol-water partition coefficients for five standard compounds determined experimentally by use of the shake-flask method were used to obtain the log Po-w values of the 1-arylpiperazines investigated. Experimentally established log Po-w values were compared with log P values calculated by use of five different software packages.", publisher = "Research Inst Medicinal Plants, Budakalasz", journal = "Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography", title = "Evaluation of the lipophilicity of some 1-arylpiperazines by planar chromatography", volume = "18", number = "105", pages = "358-363", doi = "10.1556/JPC.18.2005.5.4" }
Velickovic, J., Tešić, Ž. Lj.,& Milojković-Opsenica, D.. (2005). Evaluation of the lipophilicity of some 1-arylpiperazines by planar chromatography. in Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography Research Inst Medicinal Plants, Budakalasz., 18(105), 358-363. https://doi.org/10.1556/JPC.18.2005.5.4
Velickovic J, Tešić ŽL, Milojković-Opsenica D. Evaluation of the lipophilicity of some 1-arylpiperazines by planar chromatography. in Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography. 2005;18(105):358-363. doi:10.1556/JPC.18.2005.5.4 .
Velickovic, JD, Tešić, Živoslav Lj., Milojković-Opsenica, Dušanka, "Evaluation of the lipophilicity of some 1-arylpiperazines by planar chromatography" in Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography, 18, no. 105 (2005):358-363, https://doi.org/10.1556/JPC.18.2005.5.4 . .