Different effects of pentobarbital and pentylenetetrazol on nitric oxide levels in rat frontal cortex
Uticaj pentobarbitala i pentilenetetrazola na nivo azot oksida u frontalnom korteksu pacova
2005
Аутори
Dzoljic, ENesic, Z
Stojanović, R.
Todorović, Zoran B.
Vuckovic, S
Delic, D
Ivanović, Milovan
Prostran, M
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Levels of nitric oxide (NO) in the rats frontal cortex were continuously monitored before and after intraperitoneal administration of an antiepileptic drug-pentobarbital (20 and 40 mg/kg) or convulsant drug - pentylenetetrazol (50 mg/kg). Pentobarbital decreased the levels of NO in a dose dependent manner However, NO levels had a tendency to increase following the administration of pentylenetetrazol. It is suggested that central NO participates in the modulation of neuronal excitability, supporting the idea that NO is an important excitatory factor involved in the regulation of seizure susceptibility. Also, our results on anaesthetized rats suggests that endogenous NO may be involved in the mechanism of action of antiepileptic and analeptic drugs and this further suggest that NO levels in the human brain may decrease during antiepileptic therapy and increase during epileptic attacks or administration of excitatory drugs. The aim of the present study was to determine the possible role o...f NO levels in the brain during neuronal excitability and seizures.
Nivo azot oksida (NO) u frontalnom korteksu pacova meren je kontinuirano kako pre, tako i nakon intraperitonealne primene antiepileptika pentobarbitala (u dozi od 20 i 40 mg/kg) ili konvulzivnog agensa pentilenetetrazola (u dozi od 50 mg/kg). Rezultati ovih eksperimenta su ukazali da pentobarbital smanjuje nivo NO u frontalnom korteksu pacova, dok koncentracija NO ima tendeciju rasta nakon primene pentilenetetrazola. Osim toga, dokazano je da endogeni NO ima važnu ekscitatornu ulogu u centralnim mehanizmima nastanka epilepsije. Takođe, naši rezultati su ukazali da kod anestetisanih životinja endogeni nivo NO ima uticaja na dejstvo kako antikonvulzivnih, tako i prokonvulzivnih lekova. Nivo NO u mozgu pacova je bio snižen tokom terapije antiepilepticima, a povišen tokom epileptičkih napada ili primene lekova iz grupe centralnih stimulansa.
Кључне речи:
nitric oxide levels / pentobarbital / pentobarbital / pentylenetetrazol / pentylenetetrazol / rat frontal cortex / rat frontal codexИзвор:
Acta Veterinaria, Beograd, 2005, 55, 5-6, 367-374Издавач:
- De Gruyter Open Ltd, Warsaw
DOI: 10.2298/AVB0506367D
ISSN: 0567-8315
WoS: 000234035600003
Scopus: 2-s2.0-29344474271
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Dzoljic, E AU - Nesic, Z AU - Stojanović, R. AU - Todorović, Zoran B. AU - Vuckovic, S AU - Delic, D AU - Ivanović, Milovan AU - Prostran, M PY - 2005 UR - https://cherry.chem.bg.ac.rs/handle/123456789/744 AB - Levels of nitric oxide (NO) in the rats frontal cortex were continuously monitored before and after intraperitoneal administration of an antiepileptic drug-pentobarbital (20 and 40 mg/kg) or convulsant drug - pentylenetetrazol (50 mg/kg). Pentobarbital decreased the levels of NO in a dose dependent manner However, NO levels had a tendency to increase following the administration of pentylenetetrazol. It is suggested that central NO participates in the modulation of neuronal excitability, supporting the idea that NO is an important excitatory factor involved in the regulation of seizure susceptibility. Also, our results on anaesthetized rats suggests that endogenous NO may be involved in the mechanism of action of antiepileptic and analeptic drugs and this further suggest that NO levels in the human brain may decrease during antiepileptic therapy and increase during epileptic attacks or administration of excitatory drugs. The aim of the present study was to determine the possible role of NO levels in the brain during neuronal excitability and seizures. AB - Nivo azot oksida (NO) u frontalnom korteksu pacova meren je kontinuirano kako pre, tako i nakon intraperitonealne primene antiepileptika pentobarbitala (u dozi od 20 i 40 mg/kg) ili konvulzivnog agensa pentilenetetrazola (u dozi od 50 mg/kg). Rezultati ovih eksperimenta su ukazali da pentobarbital smanjuje nivo NO u frontalnom korteksu pacova, dok koncentracija NO ima tendeciju rasta nakon primene pentilenetetrazola. Osim toga, dokazano je da endogeni NO ima važnu ekscitatornu ulogu u centralnim mehanizmima nastanka epilepsije. Takođe, naši rezultati su ukazali da kod anestetisanih životinja endogeni nivo NO ima uticaja na dejstvo kako antikonvulzivnih, tako i prokonvulzivnih lekova. Nivo NO u mozgu pacova je bio snižen tokom terapije antiepilepticima, a povišen tokom epileptičkih napada ili primene lekova iz grupe centralnih stimulansa. PB - De Gruyter Open Ltd, Warsaw T2 - Acta Veterinaria, Beograd T1 - Different effects of pentobarbital and pentylenetetrazol on nitric oxide levels in rat frontal cortex T1 - Uticaj pentobarbitala i pentilenetetrazola na nivo azot oksida u frontalnom korteksu pacova VL - 55 IS - 5-6 SP - 367 EP - 374 DO - 10.2298/AVB0506367D ER -
@article{ author = "Dzoljic, E and Nesic, Z and Stojanović, R. and Todorović, Zoran B. and Vuckovic, S and Delic, D and Ivanović, Milovan and Prostran, M", year = "2005", abstract = "Levels of nitric oxide (NO) in the rats frontal cortex were continuously monitored before and after intraperitoneal administration of an antiepileptic drug-pentobarbital (20 and 40 mg/kg) or convulsant drug - pentylenetetrazol (50 mg/kg). Pentobarbital decreased the levels of NO in a dose dependent manner However, NO levels had a tendency to increase following the administration of pentylenetetrazol. It is suggested that central NO participates in the modulation of neuronal excitability, supporting the idea that NO is an important excitatory factor involved in the regulation of seizure susceptibility. Also, our results on anaesthetized rats suggests that endogenous NO may be involved in the mechanism of action of antiepileptic and analeptic drugs and this further suggest that NO levels in the human brain may decrease during antiepileptic therapy and increase during epileptic attacks or administration of excitatory drugs. The aim of the present study was to determine the possible role of NO levels in the brain during neuronal excitability and seizures., Nivo azot oksida (NO) u frontalnom korteksu pacova meren je kontinuirano kako pre, tako i nakon intraperitonealne primene antiepileptika pentobarbitala (u dozi od 20 i 40 mg/kg) ili konvulzivnog agensa pentilenetetrazola (u dozi od 50 mg/kg). Rezultati ovih eksperimenta su ukazali da pentobarbital smanjuje nivo NO u frontalnom korteksu pacova, dok koncentracija NO ima tendeciju rasta nakon primene pentilenetetrazola. Osim toga, dokazano je da endogeni NO ima važnu ekscitatornu ulogu u centralnim mehanizmima nastanka epilepsije. Takođe, naši rezultati su ukazali da kod anestetisanih životinja endogeni nivo NO ima uticaja na dejstvo kako antikonvulzivnih, tako i prokonvulzivnih lekova. Nivo NO u mozgu pacova je bio snižen tokom terapije antiepilepticima, a povišen tokom epileptičkih napada ili primene lekova iz grupe centralnih stimulansa.", publisher = "De Gruyter Open Ltd, Warsaw", journal = "Acta Veterinaria, Beograd", title = "Different effects of pentobarbital and pentylenetetrazol on nitric oxide levels in rat frontal cortex, Uticaj pentobarbitala i pentilenetetrazola na nivo azot oksida u frontalnom korteksu pacova", volume = "55", number = "5-6", pages = "367-374", doi = "10.2298/AVB0506367D" }
Dzoljic, E., Nesic, Z., Stojanović, R., Todorović, Z. B., Vuckovic, S., Delic, D., Ivanović, M.,& Prostran, M.. (2005). Different effects of pentobarbital and pentylenetetrazol on nitric oxide levels in rat frontal cortex. in Acta Veterinaria, Beograd De Gruyter Open Ltd, Warsaw., 55(5-6), 367-374. https://doi.org/10.2298/AVB0506367D
Dzoljic E, Nesic Z, Stojanović R, Todorović ZB, Vuckovic S, Delic D, Ivanović M, Prostran M. Different effects of pentobarbital and pentylenetetrazol on nitric oxide levels in rat frontal cortex. in Acta Veterinaria, Beograd. 2005;55(5-6):367-374. doi:10.2298/AVB0506367D .
Dzoljic, E, Nesic, Z, Stojanović, R., Todorović, Zoran B., Vuckovic, S, Delic, D, Ivanović, Milovan, Prostran, M, "Different effects of pentobarbital and pentylenetetrazol on nitric oxide levels in rat frontal cortex" in Acta Veterinaria, Beograd, 55, no. 5-6 (2005):367-374, https://doi.org/10.2298/AVB0506367D . .