Synthesis and characterization of a novel Pd(II) complex with the condensation product of 2-(diphenylphosphino) benzaldehyde and ethyl hydrazino acetate. Cytotoxic activity of the synthesized complex and related Pd(II) and Pt(II) complexes
Само за регистроване кориснике
2006
Аутори
Malesevic, NevenkaSrdić, Tatjana
Radulović, Siniša
Sladić, Dušan
Radulovic, Vesna
Brčeski, Ilija
Anđelković, Katarina K.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
A new palladium(II) complex I of the condensation product of 2-(diphenylphosphino)benzaldehyde (dpba) and ethyl hydrazinoace-tate (etha) was synthesized and characterized by elemental analyses, IR, and H-1 NMR spectroscopy. The bound ligand is a bidentate (PN chromophore), the remaining two coordination places being occupied by chloride ions in overall square planar geometry. The cytotoxic activity of the complex I and two related Pd(II) and Pt(II) complexes 2 and 3 was tested against a panel of four tumor cell lines. The activity of the complexes was similar to that of cisplatin, the most widely used metal-based antitumor drug. It is important to notice that complexes 2 and 3 were active to cisplatin-resistant U2-OS/Pt cells. Cell cycle alteration investigation, apoptotic assay and gelatin zymography in relation to invasion and metastasis of tumor cells, were performed with all the investigated complexes on Human cervix carcinoma (HeLa) cells. The results suggest that I has a similar ...effect to cisplatin, inducing apoptosis followed by arrest of cells in S phase of cell cycle, while 2 and 3 induce apoptosis without significant perturbations of cell cycle distribution. (c) 2006 Elsevier Inc. All rights reserved.
Кључне речи:
Pd(II) complexes / Pt(II) complex / cytotoxic activity / antitumor drugs / 2-(diphenylphosphino)benzaldehydeИзвор:
Journal of Inorganic Biochemistry, 2006, 100, 11, 1811-1818Издавач:
- Elsevier Science Inc, New York
Финансирање / пројекти:
- Синтеза, анализа и активност нових органских полидентатних лиганада и њихових комплекса са d-металима (RS-MESTD-MPN2006-2010-142062)
- Фармакодинамска и фармакогенетска истраживања нових лекова и предиктивна/прогностичка вредност фармакотерапије у онкологији (RS-MESTD-MPN2006-2010-145035)
DOI: 10.1016/j.jinorgbio.2006.07.002
ISSN: 0162-0134
PubMed: 16938348
WoS: 000242274800012
Scopus: 2-s2.0-33749575556
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Malesevic, Nevenka AU - Srdić, Tatjana AU - Radulović, Siniša AU - Sladić, Dušan AU - Radulovic, Vesna AU - Brčeski, Ilija AU - Anđelković, Katarina K. PY - 2006 UR - https://cherry.chem.bg.ac.rs/handle/123456789/762 AB - A new palladium(II) complex I of the condensation product of 2-(diphenylphosphino)benzaldehyde (dpba) and ethyl hydrazinoace-tate (etha) was synthesized and characterized by elemental analyses, IR, and H-1 NMR spectroscopy. The bound ligand is a bidentate (PN chromophore), the remaining two coordination places being occupied by chloride ions in overall square planar geometry. The cytotoxic activity of the complex I and two related Pd(II) and Pt(II) complexes 2 and 3 was tested against a panel of four tumor cell lines. The activity of the complexes was similar to that of cisplatin, the most widely used metal-based antitumor drug. It is important to notice that complexes 2 and 3 were active to cisplatin-resistant U2-OS/Pt cells. Cell cycle alteration investigation, apoptotic assay and gelatin zymography in relation to invasion and metastasis of tumor cells, were performed with all the investigated complexes on Human cervix carcinoma (HeLa) cells. The results suggest that I has a similar effect to cisplatin, inducing apoptosis followed by arrest of cells in S phase of cell cycle, while 2 and 3 induce apoptosis without significant perturbations of cell cycle distribution. (c) 2006 Elsevier Inc. All rights reserved. PB - Elsevier Science Inc, New York T2 - Journal of Inorganic Biochemistry T1 - Synthesis and characterization of a novel Pd(II) complex with the condensation product of 2-(diphenylphosphino) benzaldehyde and ethyl hydrazino acetate. Cytotoxic activity of the synthesized complex and related Pd(II) and Pt(II) complexes VL - 100 IS - 11 SP - 1811 EP - 1818 DO - 10.1016/j.jinorgbio.2006.07.002 ER -
@article{ author = "Malesevic, Nevenka and Srdić, Tatjana and Radulović, Siniša and Sladić, Dušan and Radulovic, Vesna and Brčeski, Ilija and Anđelković, Katarina K.", year = "2006", abstract = "A new palladium(II) complex I of the condensation product of 2-(diphenylphosphino)benzaldehyde (dpba) and ethyl hydrazinoace-tate (etha) was synthesized and characterized by elemental analyses, IR, and H-1 NMR spectroscopy. The bound ligand is a bidentate (PN chromophore), the remaining two coordination places being occupied by chloride ions in overall square planar geometry. The cytotoxic activity of the complex I and two related Pd(II) and Pt(II) complexes 2 and 3 was tested against a panel of four tumor cell lines. The activity of the complexes was similar to that of cisplatin, the most widely used metal-based antitumor drug. It is important to notice that complexes 2 and 3 were active to cisplatin-resistant U2-OS/Pt cells. Cell cycle alteration investigation, apoptotic assay and gelatin zymography in relation to invasion and metastasis of tumor cells, were performed with all the investigated complexes on Human cervix carcinoma (HeLa) cells. The results suggest that I has a similar effect to cisplatin, inducing apoptosis followed by arrest of cells in S phase of cell cycle, while 2 and 3 induce apoptosis without significant perturbations of cell cycle distribution. (c) 2006 Elsevier Inc. All rights reserved.", publisher = "Elsevier Science Inc, New York", journal = "Journal of Inorganic Biochemistry", title = "Synthesis and characterization of a novel Pd(II) complex with the condensation product of 2-(diphenylphosphino) benzaldehyde and ethyl hydrazino acetate. Cytotoxic activity of the synthesized complex and related Pd(II) and Pt(II) complexes", volume = "100", number = "11", pages = "1811-1818", doi = "10.1016/j.jinorgbio.2006.07.002" }
Malesevic, N., Srdić, T., Radulović, S., Sladić, D., Radulovic, V., Brčeski, I.,& Anđelković, K. K.. (2006). Synthesis and characterization of a novel Pd(II) complex with the condensation product of 2-(diphenylphosphino) benzaldehyde and ethyl hydrazino acetate. Cytotoxic activity of the synthesized complex and related Pd(II) and Pt(II) complexes. in Journal of Inorganic Biochemistry Elsevier Science Inc, New York., 100(11), 1811-1818. https://doi.org/10.1016/j.jinorgbio.2006.07.002
Malesevic N, Srdić T, Radulović S, Sladić D, Radulovic V, Brčeski I, Anđelković KK. Synthesis and characterization of a novel Pd(II) complex with the condensation product of 2-(diphenylphosphino) benzaldehyde and ethyl hydrazino acetate. Cytotoxic activity of the synthesized complex and related Pd(II) and Pt(II) complexes. in Journal of Inorganic Biochemistry. 2006;100(11):1811-1818. doi:10.1016/j.jinorgbio.2006.07.002 .
Malesevic, Nevenka, Srdić, Tatjana, Radulović, Siniša, Sladić, Dušan, Radulovic, Vesna, Brčeski, Ilija, Anđelković, Katarina K., "Synthesis and characterization of a novel Pd(II) complex with the condensation product of 2-(diphenylphosphino) benzaldehyde and ethyl hydrazino acetate. Cytotoxic activity of the synthesized complex and related Pd(II) and Pt(II) complexes" in Journal of Inorganic Biochemistry, 100, no. 11 (2006):1811-1818, https://doi.org/10.1016/j.jinorgbio.2006.07.002 . .
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