Synthesis, binding properties and receptor docking of 4-halo-6-[2-(4-arylpiperazin-1-yl)ethyl]-1H-benzimidazoles, mixed ligands of D(2) and 5-HT(1A) receptors
Abstract
In this publication we are describing synthesis, binding properties, and receptor docking of 4-halo-6-[2-(4-arylpiperazin-1-yl)ethyl]-1H-benzimidazoles, a new compounds with potential antipsychotics properties. Affinity towards the dopamine D(1)-like and D(2)-like, and serotonin 5-HT(1A) receptors was evaluated using the radioligand binding assays. All compounds tested had affinity for the D(2)-like and 5-HT(1A) receptors, but were inactive towards the D(1)-like receptor. Halogenated 6-[2-(4-arylpiperazin-1-yl)ethyl]-1H-benzimidazoles showed higher affinity compared to their nonhalogenated congeners. In silico docking analysis of selected ligands was performed in order to explain the results of binding assays. Our analysis suggests that stabilizing interactions between the halogen atom at the benzimidazole ring and the Ser-122 of the D(2)-like and Trp-358 of the 5-HT(1A) receptor. Energy contributions for these interactions were calculated using the ab initio method. (c) 2007 Elsevier ...Masson SAS. All rights reserved.
Keywords:
dopamine receptor / serotonin receptor / rational drug designSource:
European Journal of Medicinal Chemistry, 2008, 43, 8, 1696-1705Publisher:
- Elsevier France-Editions Scientifiques Medicales Elsevier, Paris
Funding / projects:
- Sinteza i karakterizacija biološki aktivnih supstanci i kompjuterska simulacija bioloških sistema (RS-MESTD-MPN2006-2010-142009)
DOI: 10.1016/j.ejmech.2007.09.027
ISSN: 0223-5234
PubMed: 18006194
WoS: 000259161600014
Scopus: 2-s2.0-48049117780
Collections
Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Andrić, Deana AU - Roglić, Goran AU - Šukalović, Vladimir AU - Šoškić, Vukić AU - Kostić-Rajačić, Slađana PY - 2008 UR - https://cherry.chem.bg.ac.rs/handle/123456789/969 AB - In this publication we are describing synthesis, binding properties, and receptor docking of 4-halo-6-[2-(4-arylpiperazin-1-yl)ethyl]-1H-benzimidazoles, a new compounds with potential antipsychotics properties. Affinity towards the dopamine D(1)-like and D(2)-like, and serotonin 5-HT(1A) receptors was evaluated using the radioligand binding assays. All compounds tested had affinity for the D(2)-like and 5-HT(1A) receptors, but were inactive towards the D(1)-like receptor. Halogenated 6-[2-(4-arylpiperazin-1-yl)ethyl]-1H-benzimidazoles showed higher affinity compared to their nonhalogenated congeners. In silico docking analysis of selected ligands was performed in order to explain the results of binding assays. Our analysis suggests that stabilizing interactions between the halogen atom at the benzimidazole ring and the Ser-122 of the D(2)-like and Trp-358 of the 5-HT(1A) receptor. Energy contributions for these interactions were calculated using the ab initio method. (c) 2007 Elsevier Masson SAS. All rights reserved. PB - Elsevier France-Editions Scientifiques Medicales Elsevier, Paris T2 - European Journal of Medicinal Chemistry T1 - Synthesis, binding properties and receptor docking of 4-halo-6-[2-(4-arylpiperazin-1-yl)ethyl]-1H-benzimidazoles, mixed ligands of D(2) and 5-HT(1A) receptors VL - 43 IS - 8 SP - 1696 EP - 1705 DO - 10.1016/j.ejmech.2007.09.027 ER -
@article{ author = "Andrić, Deana and Roglić, Goran and Šukalović, Vladimir and Šoškić, Vukić and Kostić-Rajačić, Slađana", year = "2008", abstract = "In this publication we are describing synthesis, binding properties, and receptor docking of 4-halo-6-[2-(4-arylpiperazin-1-yl)ethyl]-1H-benzimidazoles, a new compounds with potential antipsychotics properties. Affinity towards the dopamine D(1)-like and D(2)-like, and serotonin 5-HT(1A) receptors was evaluated using the radioligand binding assays. All compounds tested had affinity for the D(2)-like and 5-HT(1A) receptors, but were inactive towards the D(1)-like receptor. Halogenated 6-[2-(4-arylpiperazin-1-yl)ethyl]-1H-benzimidazoles showed higher affinity compared to their nonhalogenated congeners. In silico docking analysis of selected ligands was performed in order to explain the results of binding assays. Our analysis suggests that stabilizing interactions between the halogen atom at the benzimidazole ring and the Ser-122 of the D(2)-like and Trp-358 of the 5-HT(1A) receptor. Energy contributions for these interactions were calculated using the ab initio method. (c) 2007 Elsevier Masson SAS. All rights reserved.", publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Paris", journal = "European Journal of Medicinal Chemistry", title = "Synthesis, binding properties and receptor docking of 4-halo-6-[2-(4-arylpiperazin-1-yl)ethyl]-1H-benzimidazoles, mixed ligands of D(2) and 5-HT(1A) receptors", volume = "43", number = "8", pages = "1696-1705", doi = "10.1016/j.ejmech.2007.09.027" }
Andrić, D., Roglić, G., Šukalović, V., Šoškić, V.,& Kostić-Rajačić, S.. (2008). Synthesis, binding properties and receptor docking of 4-halo-6-[2-(4-arylpiperazin-1-yl)ethyl]-1H-benzimidazoles, mixed ligands of D(2) and 5-HT(1A) receptors. in European Journal of Medicinal Chemistry Elsevier France-Editions Scientifiques Medicales Elsevier, Paris., 43(8), 1696-1705. https://doi.org/10.1016/j.ejmech.2007.09.027
Andrić D, Roglić G, Šukalović V, Šoškić V, Kostić-Rajačić S. Synthesis, binding properties and receptor docking of 4-halo-6-[2-(4-arylpiperazin-1-yl)ethyl]-1H-benzimidazoles, mixed ligands of D(2) and 5-HT(1A) receptors. in European Journal of Medicinal Chemistry. 2008;43(8):1696-1705. doi:10.1016/j.ejmech.2007.09.027 .
Andrić, Deana, Roglić, Goran, Šukalović, Vladimir, Šoškić, Vukić, Kostić-Rajačić, Slađana, "Synthesis, binding properties and receptor docking of 4-halo-6-[2-(4-arylpiperazin-1-yl)ethyl]-1H-benzimidazoles, mixed ligands of D(2) and 5-HT(1A) receptors" in European Journal of Medicinal Chemistry, 43, no. 8 (2008):1696-1705, https://doi.org/10.1016/j.ejmech.2007.09.027 . .