TY  - JOUR
AU  - Paiga, Paula
AU  - Lolić, Aleksandar
AU  - Hellebuyck, Floris
AU  - Santos, Lucia H. M. L. M.
AU  - Correia, Manuela
AU  - Delerue-Matos, Cristina
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1674
AB  - An analytical methodology for the simultaneous determination of seven pharmaceuticals and two metabolites belonging to the non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics therapeutic groups was developed based on off-line solid-phase extraction and ultra-high performance liquid chromatography coupled to tandem mass spectrometry (SPE-UHPLC-MS/MS). Extraction conditions were optimized taking into account parameters like sorbent material, sample volume and sample pH. Method detection limits (MDLs) ranging from 0.02 to 8.18 ng/L were obtained. This methodology was successfully applied to the determination of the selected pharmaceuticals in seawater samples of Atlantic Ocean in the Northern Portuguese coast. All the pharmaceuticals have been detected in the seawater samples, with pharmaceuticals like ibuprofen, acetaminophen, ketoprofen and the metabolite hydroxyibuprofen being the most frequently detected at concentrations that can reach some hundreds of ng/L.
PB  - Elsevier Science Bv, Amsterdam
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater
VL  - 106
SP  - 61
EP  - 70
DO  - 10.1016/j.jpba.2014.06.017
ER  - 

@article{
author = "Paiga, Paula and Lolić, Aleksandar and Hellebuyck, Floris and Santos, Lucia H. M. L. M. and Correia, Manuela and Delerue-Matos, Cristina",
year = "2015",
abstract = "An analytical methodology for the simultaneous determination of seven pharmaceuticals and two metabolites belonging to the non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics therapeutic groups was developed based on off-line solid-phase extraction and ultra-high performance liquid chromatography coupled to tandem mass spectrometry (SPE-UHPLC-MS/MS). Extraction conditions were optimized taking into account parameters like sorbent material, sample volume and sample pH. Method detection limits (MDLs) ranging from 0.02 to 8.18 ng/L were obtained. This methodology was successfully applied to the determination of the selected pharmaceuticals in seawater samples of Atlantic Ocean in the Northern Portuguese coast. All the pharmaceuticals have been detected in the seawater samples, with pharmaceuticals like ibuprofen, acetaminophen, ketoprofen and the metabolite hydroxyibuprofen being the most frequently detected at concentrations that can reach some hundreds of ng/L.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater",
volume = "106",
pages = "61-70",
doi = "10.1016/j.jpba.2014.06.017"
}

Paiga, P., Lolić, A., Hellebuyck, F., Santos, L. H. M. L. M., Correia, M.,& Delerue-Matos, C.. (2015). Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater. in Journal of Pharmaceutical and Biomedical Analysis
Elsevier Science Bv, Amsterdam., 106, 61-70.
https://doi.org/10.1016/j.jpba.2014.06.017

Paiga P, Lolić A, Hellebuyck F, Santos LHMLM, Correia M, Delerue-Matos C. Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater. in Journal of Pharmaceutical and Biomedical Analysis. 2015;106:61-70.
doi:10.1016/j.jpba.2014.06.017 .

Paiga, Paula, Lolić, Aleksandar, Hellebuyck, Floris, Santos, Lucia H. M. L. M., Correia, Manuela, Delerue-Matos, Cristina, "Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater" in Journal of Pharmaceutical and Biomedical Analysis, 106 (2015):61-70,
https://doi.org/10.1016/j.jpba.2014.06.017 . .

TY  - DATA
AU  - Paiga, Paula
AU  - Lolić, Aleksandar
AU  - Hellebuyck, Floris
AU  - Santos, Lucia H. M. L. M.
AU  - Correia, Manuela
AU  - Delerue-Matos, Cristina
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3362
PB  - Elsevier Science Bv, Amsterdam
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Supplementary data for article: Paíga, P.; Lolić, A.; Hellebuyck, F.; Santos, L. H. M. L.; Correia, M.; Delerue-Matos, C. Development of a SPE-UHPLC-MS/MS Methodology for the Determination of Non-Steroidal Anti-Inflammatory and Analgesic Pharmaceuticals in Seawater. Journal of Pharmaceutical and Biomedical Analysis 2015, 106, 61–70. https://doi.org/10.1016/j.jpba.2014.06.017
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3362
ER  - 

@misc{
author = "Paiga, Paula and Lolić, Aleksandar and Hellebuyck, Floris and Santos, Lucia H. M. L. M. and Correia, Manuela and Delerue-Matos, Cristina",
year = "2015",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Supplementary data for article: Paíga, P.; Lolić, A.; Hellebuyck, F.; Santos, L. H. M. L.; Correia, M.; Delerue-Matos, C. Development of a SPE-UHPLC-MS/MS Methodology for the Determination of Non-Steroidal Anti-Inflammatory and Analgesic Pharmaceuticals in Seawater. Journal of Pharmaceutical and Biomedical Analysis 2015, 106, 61–70. https://doi.org/10.1016/j.jpba.2014.06.017",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3362"
}

Paiga, P., Lolić, A., Hellebuyck, F., Santos, L. H. M. L. M., Correia, M.,& Delerue-Matos, C.. (2015). Supplementary data for article: Paíga, P.; Lolić, A.; Hellebuyck, F.; Santos, L. H. M. L.; Correia, M.; Delerue-Matos, C. Development of a SPE-UHPLC-MS/MS Methodology for the Determination of Non-Steroidal Anti-Inflammatory and Analgesic Pharmaceuticals in Seawater. Journal of Pharmaceutical and Biomedical Analysis 2015, 106, 61–70. https://doi.org/10.1016/j.jpba.2014.06.017. in Journal of Pharmaceutical and Biomedical Analysis
Elsevier Science Bv, Amsterdam..
https://hdl.handle.net/21.15107/rcub_cherry_3362

Paiga P, Lolić A, Hellebuyck F, Santos LHMLM, Correia M, Delerue-Matos C. Supplementary data for article: Paíga, P.; Lolić, A.; Hellebuyck, F.; Santos, L. H. M. L.; Correia, M.; Delerue-Matos, C. Development of a SPE-UHPLC-MS/MS Methodology for the Determination of Non-Steroidal Anti-Inflammatory and Analgesic Pharmaceuticals in Seawater. Journal of Pharmaceutical and Biomedical Analysis 2015, 106, 61–70. https://doi.org/10.1016/j.jpba.2014.06.017. in Journal of Pharmaceutical and Biomedical Analysis. 2015;.
https://hdl.handle.net/21.15107/rcub_cherry_3362 .

Paiga, Paula, Lolić, Aleksandar, Hellebuyck, Floris, Santos, Lucia H. M. L. M., Correia, Manuela, Delerue-Matos, Cristina, "Supplementary data for article: Paíga, P.; Lolić, A.; Hellebuyck, F.; Santos, L. H. M. L.; Correia, M.; Delerue-Matos, C. Development of a SPE-UHPLC-MS/MS Methodology for the Determination of Non-Steroidal Anti-Inflammatory and Analgesic Pharmaceuticals in Seawater. Journal of Pharmaceutical and Biomedical Analysis 2015, 106, 61–70. https://doi.org/10.1016/j.jpba.2014.06.017" in Journal of Pharmaceutical and Biomedical Analysis (2015),
https://hdl.handle.net/21.15107/rcub_cherry_3362 .