TY  - JOUR
AU  - Gligorijević, Nevenka
AU  - Aranđelović, Sandra
AU  - Filipović, Lana
AU  - Jakovljević, Ksenija
AU  - Jankovic, Radmila
AU  - Grgurić-Šipka, Sanja
AU  - Ivanović, Ivanka
AU  - Radulović, Siniša
AU  - Tešić, Živoslav Lj.
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1270
AB  - In our previous study, ruthenium(II)-p-cymene complexes of general formula [(eta(6)-p-cymene)Ru(L)Cl2], L: 3-acetylpyridine (1), 2-amino-5-chloropyridine (2); and [(eta(6)-p-cymene)Ru(HL)Cl], HL: 2,3-pyridinedicarboxylic acid (3), 2,4-pyridinedicarboxylic acid (4), revealed low antiproliferative activity, except complex [(eta(6)-p-cymene)RuCl(picolinic acid)]center dot H2O (5) which exhibited IC50 around 80 mu M. In this study we further investigated in vitro potential of antimetastatic action of ruthenium complexes on HeLa and two endothelial cell lines. Comparison of structure and activity of five complexes indicated heterogenic mode of activity, with regard to the potential of antimetastatic and antiproliferative effect. Replacement of substituted pyridine ligand with picolinic acid (complex 5) around Ru(II) center contributed to complex cytotoxicity and ruthenium DNA binding affinity. Analysis of ruthenium(II) accumulation in DNA and protein fractions of HeLa cells, using ICP-OES revealed significantly higher content of complex 5 in DNA fraction in comparison to the other tested compounds. It also altered cell cycle progression, affected expression of DNA repair enzymes ERCC1 and MSH2, and showed enhanced activity in combination with 3-aminobenzamide. Regardless of their effect on cell growth, Ru(II) complexes exerted antimetastatic effect on several tumor cell lines in vitro, achieved mostly by the effect on cell adhesion, migration and angiogenesis, while picolinate ruthenium(II)-arene additionally exerted inhibitory effect on extracellular matrix degradation. (c) 2011 Elsevier Inc. All rights reserved.
PB  - Elsevier Science Inc, New York
T2  - Journal of Inorganic Biochemistry
T1  - Picolinate ruthenium(II)-arene complex with in vitro antiproliferative and antimetastatic properties: Comparison to a series of ruthenium(II)-arene complexes with similar structure
VL  - 108
SP  - 53
EP  - 61
DO  - 10.1016/j.jinorgbio.2011.12.002
ER  - 

@article{
author = "Gligorijević, Nevenka and Aranđelović, Sandra and Filipović, Lana and Jakovljević, Ksenija and Jankovic, Radmila and Grgurić-Šipka, Sanja and Ivanović, Ivanka and Radulović, Siniša and Tešić, Živoslav Lj.",
year = "2012",
abstract = "In our previous study, ruthenium(II)-p-cymene complexes of general formula [(eta(6)-p-cymene)Ru(L)Cl2], L: 3-acetylpyridine (1), 2-amino-5-chloropyridine (2); and [(eta(6)-p-cymene)Ru(HL)Cl], HL: 2,3-pyridinedicarboxylic acid (3), 2,4-pyridinedicarboxylic acid (4), revealed low antiproliferative activity, except complex [(eta(6)-p-cymene)RuCl(picolinic acid)]center dot H2O (5) which exhibited IC50 around 80 mu M. In this study we further investigated in vitro potential of antimetastatic action of ruthenium complexes on HeLa and two endothelial cell lines. Comparison of structure and activity of five complexes indicated heterogenic mode of activity, with regard to the potential of antimetastatic and antiproliferative effect. Replacement of substituted pyridine ligand with picolinic acid (complex 5) around Ru(II) center contributed to complex cytotoxicity and ruthenium DNA binding affinity. Analysis of ruthenium(II) accumulation in DNA and protein fractions of HeLa cells, using ICP-OES revealed significantly higher content of complex 5 in DNA fraction in comparison to the other tested compounds. It also altered cell cycle progression, affected expression of DNA repair enzymes ERCC1 and MSH2, and showed enhanced activity in combination with 3-aminobenzamide. Regardless of their effect on cell growth, Ru(II) complexes exerted antimetastatic effect on several tumor cell lines in vitro, achieved mostly by the effect on cell adhesion, migration and angiogenesis, while picolinate ruthenium(II)-arene additionally exerted inhibitory effect on extracellular matrix degradation. (c) 2011 Elsevier Inc. All rights reserved.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Inorganic Biochemistry",
title = "Picolinate ruthenium(II)-arene complex with in vitro antiproliferative and antimetastatic properties: Comparison to a series of ruthenium(II)-arene complexes with similar structure",
volume = "108",
pages = "53-61",
doi = "10.1016/j.jinorgbio.2011.12.002"
}

Gligorijević, N., Aranđelović, S., Filipović, L., Jakovljević, K., Jankovic, R., Grgurić-Šipka, S., Ivanović, I., Radulović, S.,& Tešić, Ž. Lj.. (2012). Picolinate ruthenium(II)-arene complex with in vitro antiproliferative and antimetastatic properties: Comparison to a series of ruthenium(II)-arene complexes with similar structure. in Journal of Inorganic Biochemistry
Elsevier Science Inc, New York., 108, 53-61.
https://doi.org/10.1016/j.jinorgbio.2011.12.002

Gligorijević N, Aranđelović S, Filipović L, Jakovljević K, Jankovic R, Grgurić-Šipka S, Ivanović I, Radulović S, Tešić ŽL. Picolinate ruthenium(II)-arene complex with in vitro antiproliferative and antimetastatic properties: Comparison to a series of ruthenium(II)-arene complexes with similar structure. in Journal of Inorganic Biochemistry. 2012;108:53-61.
doi:10.1016/j.jinorgbio.2011.12.002 .

Gligorijević, Nevenka, Aranđelović, Sandra, Filipović, Lana, Jakovljević, Ksenija, Jankovic, Radmila, Grgurić-Šipka, Sanja, Ivanović, Ivanka, Radulović, Siniša, Tešić, Živoslav Lj., "Picolinate ruthenium(II)-arene complex with in vitro antiproliferative and antimetastatic properties: Comparison to a series of ruthenium(II)-arene complexes with similar structure" in Journal of Inorganic Biochemistry, 108 (2012):53-61,
https://doi.org/10.1016/j.jinorgbio.2011.12.002 . .

TY  - CONF
AU  - Čavić, Milena
AU  - Bajić, A.
AU  - Grozdanović, M.
AU  - Cavic, D.
AU  - Jakovljević, Ksenija
AU  - Andjus, P.
AU  - Gavrović-Jankulović, Marija
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1543
PB  - Wiley-Blackwell, Hoboken
C3  - Allergy
T1  - Kiwifruit allergen actinidin disrupts the epithelial monolayer integrity of human intestinal T84 cells
VL  - 67
SP  - 602
EP  - 603
UR  - https://hdl.handle.net/21.15107/rcub_cherry_1543
ER  - 

@conference{
author = "Čavić, Milena and Bajić, A. and Grozdanović, M. and Cavic, D. and Jakovljević, Ksenija and Andjus, P. and Gavrović-Jankulović, Marija",
year = "2012",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Allergy",
title = "Kiwifruit allergen actinidin disrupts the epithelial monolayer integrity of human intestinal T84 cells",
volume = "67",
pages = "602-603",
url = "https://hdl.handle.net/21.15107/rcub_cherry_1543"
}

Čavić, M., Bajić, A., Grozdanović, M., Cavic, D., Jakovljević, K., Andjus, P.,& Gavrović-Jankulović, M.. (2012). Kiwifruit allergen actinidin disrupts the epithelial monolayer integrity of human intestinal T84 cells. in Allergy
Wiley-Blackwell, Hoboken., 67, 602-603.
https://hdl.handle.net/21.15107/rcub_cherry_1543

Čavić M, Bajić A, Grozdanović M, Cavic D, Jakovljević K, Andjus P, Gavrović-Jankulović M. Kiwifruit allergen actinidin disrupts the epithelial monolayer integrity of human intestinal T84 cells. in Allergy. 2012;67:602-603.
https://hdl.handle.net/21.15107/rcub_cherry_1543 .

Čavić, Milena, Bajić, A., Grozdanović, M., Cavic, D., Jakovljević, Ksenija, Andjus, P., Gavrović-Jankulović, Marija, "Kiwifruit allergen actinidin disrupts the epithelial monolayer integrity of human intestinal T84 cells" in Allergy, 67 (2012):602-603,
https://hdl.handle.net/21.15107/rcub_cherry_1543 .