TY  - JOUR
AU  - Popović, Gordana V.
AU  - Sladić, Dušan
AU  - Stefanovic, VM
AU  - Pfendt, Lidija B.
PY  - 2003
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/549
AB  - Protolytic equilibria in homogeneous and heterogeneous systems of lorazepam and oxazepam, which are sparingly soluble ampholytes from the class of 1,4-benzodiazepines, were studied at 25 degreesC and ionic strength of 0.1 M. Acidity constants and equilibrium constants in a heterogeneous system were determined. On the basis of the analysis of the corresponding C-13- and H-1-NMR spectra, deprotonation site in the molecules of the investigated compounds was predicted. Finally, the correlation between chemical shifts in the H-1-NMR spectra and the acidity of the amide proton of 1,4-benzodiazepines was established. (C) 2003 Elsevier Science B.V. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Study on protolytic equilibria of lorazepam and oxazepam by UV and NMR spectroscopy
VL  - 31
IS  - 4
SP  - 693
EP  - 699
DO  - 10.1016/S0731-7085(02)00686-6
ER  - 

@article{
author = "Popović, Gordana V. and Sladić, Dušan and Stefanovic, VM and Pfendt, Lidija B.",
year = "2003",
abstract = "Protolytic equilibria in homogeneous and heterogeneous systems of lorazepam and oxazepam, which are sparingly soluble ampholytes from the class of 1,4-benzodiazepines, were studied at 25 degreesC and ionic strength of 0.1 M. Acidity constants and equilibrium constants in a heterogeneous system were determined. On the basis of the analysis of the corresponding C-13- and H-1-NMR spectra, deprotonation site in the molecules of the investigated compounds was predicted. Finally, the correlation between chemical shifts in the H-1-NMR spectra and the acidity of the amide proton of 1,4-benzodiazepines was established. (C) 2003 Elsevier Science B.V. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Study on protolytic equilibria of lorazepam and oxazepam by UV and NMR spectroscopy",
volume = "31",
number = "4",
pages = "693-699",
doi = "10.1016/S0731-7085(02)00686-6"
}

Popović, G. V., Sladić, D., Stefanovic, V.,& Pfendt, L. B.. (2003). Study on protolytic equilibria of lorazepam and oxazepam by UV and NMR spectroscopy. in Journal of Pharmaceutical and Biomedical Analysis
Pergamon-Elsevier Science Ltd, Oxford., 31(4), 693-699.
https://doi.org/10.1016/S0731-7085(02)00686-6

Popović GV, Sladić D, Stefanovic V, Pfendt LB. Study on protolytic equilibria of lorazepam and oxazepam by UV and NMR spectroscopy. in Journal of Pharmaceutical and Biomedical Analysis. 2003;31(4):693-699.
doi:10.1016/S0731-7085(02)00686-6 .

Popović, Gordana V., Sladić, Dušan, Stefanovic, VM, Pfendt, Lidija B., "Study on protolytic equilibria of lorazepam and oxazepam by UV and NMR spectroscopy" in Journal of Pharmaceutical and Biomedical Analysis, 31, no. 4 (2003):693-699,
https://doi.org/10.1016/S0731-7085(02)00686-6 . .