TY  - JOUR
AU  - Jaćević, Vesna
AU  - Dumanović, Jelena
AU  - Lazarević, Miodrag
AU  - Nepovimova, Eugenie
AU  - Resanović, Radmila
AU  - Milovanović, Zoran
AU  - Wu, Qinghua
AU  - Kuča, Kamil
PY  - 2020
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4258
AB  - In this paper, the potential antidote efficacy of commercially available formulations of various feed additives such as Minazel-Plus®, Mycosorb®, and Mycofix® was considered by recording their incidence on general health, body weight, and food and water intake, as well as through histopathology and semiquantitative analysis of gastric alterations in Wistar rats treated with the T-2 toxin in a single-dose regimen of 1.67 mg/kg p.o. (1 LD50) for 4 weeks. As an organic adsorbent, Mycosorb® successfully antagonized acute lethal incidence of the T-2 toxin (protective index (PI) = 2.25; p < 0.05 vs. T-2 toxin), and had adverse effects on body weight gain as well as food and water intake during the research (p < 0.001). However, the protective efficacy of the other two food additives was significantly lower (p < 0.05). Treatment with Mycosorb® significantly reduced the severity of gastric damage, which was not the case when the other two adsorbents were used. Our results suggest that Mycosorb® is a much better adsorbent for preventing the adverse impact of the T-2 toxin as well as its toxic metabolites compared with Minazel-plus® or Mycofix-plus®, and it almost completely suppresses its acute toxic effects and cytotoxic potential on the gastric epithelial, glandular, and vascular endothelial cells.
PB  - MDPI
T2  - Toxins
T1  - Antidotal Potency of the Novel, Structurally Different Adsorbents in Rats Acutely Intoxicated with the T-2 Toxin
VL  - 12
IS  - 10
SP  - 643
DO  - 10.3390/toxins12100643
ER  - 

@article{
author = "Jaćević, Vesna and Dumanović, Jelena and Lazarević, Miodrag and Nepovimova, Eugenie and Resanović, Radmila and Milovanović, Zoran and Wu, Qinghua and Kuča, Kamil",
year = "2020",
abstract = "In this paper, the potential antidote efficacy of commercially available formulations of various feed additives such as Minazel-Plus®, Mycosorb®, and Mycofix® was considered by recording their incidence on general health, body weight, and food and water intake, as well as through histopathology and semiquantitative analysis of gastric alterations in Wistar rats treated with the T-2 toxin in a single-dose regimen of 1.67 mg/kg p.o. (1 LD50) for 4 weeks. As an organic adsorbent, Mycosorb® successfully antagonized acute lethal incidence of the T-2 toxin (protective index (PI) = 2.25; p < 0.05 vs. T-2 toxin), and had adverse effects on body weight gain as well as food and water intake during the research (p < 0.001). However, the protective efficacy of the other two food additives was significantly lower (p < 0.05). Treatment with Mycosorb® significantly reduced the severity of gastric damage, which was not the case when the other two adsorbents were used. Our results suggest that Mycosorb® is a much better adsorbent for preventing the adverse impact of the T-2 toxin as well as its toxic metabolites compared with Minazel-plus® or Mycofix-plus®, and it almost completely suppresses its acute toxic effects and cytotoxic potential on the gastric epithelial, glandular, and vascular endothelial cells.",
publisher = "MDPI",
journal = "Toxins",
title = "Antidotal Potency of the Novel, Structurally Different Adsorbents in Rats Acutely Intoxicated with the T-2 Toxin",
volume = "12",
number = "10",
pages = "643",
doi = "10.3390/toxins12100643"
}

Jaćević, V., Dumanović, J., Lazarević, M., Nepovimova, E., Resanović, R., Milovanović, Z., Wu, Q.,& Kuča, K.. (2020). Antidotal Potency of the Novel, Structurally Different Adsorbents in Rats Acutely Intoxicated with the T-2 Toxin. in Toxins
MDPI., 12(10), 643.
https://doi.org/10.3390/toxins12100643

Jaćević V, Dumanović J, Lazarević M, Nepovimova E, Resanović R, Milovanović Z, Wu Q, Kuča K. Antidotal Potency of the Novel, Structurally Different Adsorbents in Rats Acutely Intoxicated with the T-2 Toxin. in Toxins. 2020;12(10):643.
doi:10.3390/toxins12100643 .

Jaćević, Vesna, Dumanović, Jelena, Lazarević, Miodrag, Nepovimova, Eugenie, Resanović, Radmila, Milovanović, Zoran, Wu, Qinghua, Kuča, Kamil, "Antidotal Potency of the Novel, Structurally Different Adsorbents in Rats Acutely Intoxicated with the T-2 Toxin" in Toxins, 12, no. 10 (2020):643,
https://doi.org/10.3390/toxins12100643 . .