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Effects of several atypical antipsychotics closapine, sertindole or ziprasidone on hepatic antioxidant enzymes: Possible role in drug-induced liver dysfunction
(Taylor and Francis, 2021)
Chronic use of atypical antipsychotics may produce hepatic damage. Atypical antipsychotics, including clozapine, sertindole, and ziprasidone, are extensively metabolized by the liver and this process generates toxic-free ...
Lipidomics provides new insight into pathogenesis and therapeutic targets of the ischemia—reperfusion injury
(MDPI, 2021)
Lipids play an essential role in both tissue protection and damage. Tissue ischemia creates anaerobic conditions in which enzyme inactivation occurs, and reperfusion can initiate oxidative stress that leads to harmful ...
The Effects of a Meldonium Pre-Treatment on the Course of the Faecal-Induced Sepsis in Rats
(MDPI, 2021)
Sepsis is a life-threatening condition caused by the dysregulated and overwhelming response to infection, accompanied by an exaggerated pro-inflammatory state and lipid metabolism disturbance leading to sequential organ ...