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Structural modifications of 4-aryl-4-oxo-2-aminylbutanamides and their acetyl- and butyrylcholinesterase inhibitory activity. Investigation of AChE-ligand interactions by docking calculations and molecular dynamics simulations
(Elsevier France-Editions Scientifiques Medicales Elsevier, Paris, 2014)
Congeneric set of thirty-eight 4-aryl-4-oxo-2-(N-aryl/cycloalkyl)butanamides has been designed, synthesized and evaluated for acetyl- and butyrylcholinesterase inhibitory activity. Structural variations included cycloalkylamino ...
Chemical modification of chloroperoxidase for enhanced stability and activity
(Elsevier Sci Ltd, Oxford, 2014)
Chloroperoxidase from Caldariomyces fumago (CPO, EC 1.11.1.10) is one of the most interesting enzymes from the group of heme peroxidases and has been extensively applied in synthetic processes. Nevertheless, the practical ...
Isolation, characterization and in vitro cytotoxicity of new sesquiterpenoids from Achillea clavennae
(Georg Thieme Verlag, 2014)
Further phytochemical investigation into the aerial parts of Achillea clavennae has resulted in the 3
isolation of three new sesquiterpene lactones: two highly oxygenated germacranolides (1, 2) and 4
the iso-seco-guaianolide, ...