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Optimization of the expression conditions of fluorescently labeled α-synuclein in Escherichia coli by response surface methodology and proteolysis by tobacco etch virus protease
(Serbian Chemical SocietySerbian Young Chemists’ Club, 2022)
Alpha-synuclein is an intrinsically disordered protein prone to aggregation and it is involved in the formation of brain tissue amyloids in patients with Parkinson's and other neurodegenerative diseases. By fluorescently ...
Total phenolic content and antioxidant capacity of Norwegian plums
(Belgrade : Serbian Young Chemists’ ClubBelgrade : Serbian Chemical Society, 2022)
European plum (Prunus domestica L.) is a very adaptable fruit species with a large spreading area, but it is mostly grown under the temperate climatic conditions. Plum production has a very long tradition in Norway, which ...
Comparative analysis of ionization constants determination using spectrophotometry and potentiometry: 3- aminobenzoic acid, 1,3,5-benzenetricarboxylic acid and tyrosine
(Belgrade : Serbian Chemical SocietyBelgrade : Serbian Young Chemists’ Club, 2022)
The ionization constant (usually expressed in logarithmic form, pKa) is important
physicochemical parameter which is used to characterize the acid-base chemistry of a
compound. Since most drugs contain one or more ...
Investigation of clofazimine acid-base supersolubilization using various weak organic acids
(Belgrade : Serbian Chemical SocietyBelgrade : Serbian Young Chemists’ Club, 2022)
Nowadays, more than two-thirds of potential drugs currently being discovered are
practically insoluble in water with solubility <100 μg/mL. Despite that, compounds with
even lower solubility (<0.1 μg/mL) are commonly ...
The influence of competing counterions on the solubility of imipramine
(Belgrade : Serbian Chemical SocietyBelgrade : Serbian Young Chemists’ Club, 2022)
Experimental studies of solubility are important in all phases of drug design and
development. Solubility data are used to screen out drug-like candidates,
biopharmaceutical classification and formulation optimization. ...
The effect of methanesulfonic and glutaric acids on the solubility of clofazimine
(Belgrade : Serbian Chemical SocietyBelgrade : Serbian Young Chemists’ Club, 2022)
In the modern drug research the number of practically insoluble potential drugs is
increasing. Poor aqueous solubility can cause poor oral absorption and low
bioavailability of drugs. Hence, solubility enhancement is ...
Optimization of extraction conditions of tropomyosin from Mediterranean mussel and its quantification by developed ELISA
(Beograd : Srpsko hemijsko društvoBeograd : Klub mladih hemičara Srbije, 2022)
Tropomyosin (TPM) is a major allergen among different shellfish species. Developing sensitive, specific, and reliable methods for quantifying TPM in food products is crucial for persons allergic to shellfish. Commonly used ...