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dc.creatorLazic, Jelena M.
dc.creatorVucicevic, Ljubica
dc.creatorGrgurić-Šipka, Sanja
dc.creatorJanjetovic, Kristina
dc.creatorKaluđerović, Goran N.
dc.creatorMisirkic, Maja
dc.creatorGruden-Pavlović, Maja
dc.creatorPopadic, Dusan
dc.creatorPaschke, Reinhard
dc.creatorTrajković, Vladimir S.
dc.creatorSabo, Tibor
dc.date.accessioned2018-11-22T00:16:32Z
dc.date.available2018-11-22T00:16:32Z
dc.date.issued2010
dc.identifier.issn1860-7179
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/1088
dc.description.abstractThe present study describes the synthesis and anticancer activity of novel octahedral Pt-IV complexes with cyclohexyl functionalized ethylenediamine-N,N'-diacetate-type ligands. Molecular mechanics calculations and density functional theory analysis revealed that s-cis is the preferred geometry of these Pt-IV complexes with tetradentate-coordinated (S,S)-ethylenediamineN,N'-di-2-(3-cyclohexyl)propanoate. The viability of cancer cell lines (U251 human glioma, C6 rat glioma, L929 mouse fibrosarcoma, and B16 human melanoma) was assessed by measuring mitochondrial dehydrogenase activity and lactate dehydrogenase release. Cell-cycle distribution, oxidative stress, caspase activation, and induction of autophagy were analyzed by flow cytometry using appropriate fluorescent reporter dyes. The cytotoxic activity of novel Pt-IV complexes against various cancer cell lines (IC50 range: 1.9-8.7 mu m) was higher than that of cisplatin (IC50 range: 10.9-67.0 mu m) and proceeded through completely different mechanisms. Cisplatin induced caspase-dependent apoptosis associated with the cytoprotective autophagic response. In contrast, the new Pt-IV complexes caused rapid, caspase-independent, oxidative stress-mediated non-apoptotic cell death characterized by massive cytoplasmic vacuolization, cell membrane damage, and the absence of protective autophagy.en
dc.publisherWiley-V C H Verlag Gmbh, Weinheim
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142010/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145073/RS//
dc.rightsrestrictedAccess
dc.sourceChemMedChem
dc.subjectapoptosisen
dc.subjectautophagyen
dc.subjectcanceren
dc.subjectoxidative stressen
dc.subjectplatinumen
dc.titleSynthesis and in vitro Anticancer Activity of Octahedral Platinum(IV) Complexes with Cyclohexyl-Functionalized Ethylenediamine-N,N '-Diacetate-Type Ligandsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈањетовиц, Кристина; Вуцицевиц, Љубица; Пасцхке, Реинхард; Трајковиц, Владимир; Сабо, Тибор; Груден-Павловић, Маја; Калудеровиц, Горан Н.; Гргурић-Шипка, Сања; Лазиц, Јелена М.; Попадиц, Дусан; Мисиркиц, Маја;
dc.citation.volume5
dc.citation.issue6
dc.citation.spage881
dc.citation.epage889
dc.identifier.wos000278969200010
dc.identifier.doi10.1002/cmdc.201000058
dc.citation.other5(6): 881-889
dc.citation.rankM21
dc.identifier.pmid20408161
dc.type.versionpublishedVersionen
dc.identifier.scopus2-s2.0-77953095723
dc.identifier.rcubKon_2088


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