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dc.creatorOpsenica, Dejan M.
dc.creatorŠolaja, Bogdan A.
dc.date.accessioned2018-11-22T00:22:36Z
dc.date.available2018-11-22T00:22:36Z
dc.date.issued2012
dc.identifier.issn1857-5552
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/1579
dc.description.abstractMalaria is devastating disease and global public health problem, with nearly half world population exposed to risk. Illness is caused by five Plasmodium species, P falciparum, P ovale, P viva; P malaria and P knowlesi, from which P falciparum is the most serious one causing cerebral malaria and is the major reason for malaria mortality. Vaccine against malaria is not expected in the near future and chemotherapy remains as most feasible alternative for treatment of the disease. The development of widespread drug-resistance to chloroquine (CQ), the most successful antimalarial drug up to date, has resulted in severe health issues for countries in malaria endemic regions. Organic peroxides, like artemisinins, 1,2,4-trioxanes, 1,2,4-trioxolanes, 1,2,4,5-tetraoxanes and their chimeras, are the best choice for malaria treatment nowadays. These therapeutics are fast acting, non-toxic, low costing and without reported data of parasite resistance. Stability of peroxide bonds enables synthetic comfort and resulting in diversity of synthesized structures. The most important classes of peroxide antimalarials with promising representatives are reviewed and possible mechanisms of action were presented in details.en
dc.publisherSoc Chemists Technologists Madeconia, Skopje
dc.rightsrestrictedAccess
dc.sourceMacedonian Journal of Chemistry and Chemical Engineering
dc.subjectantimalarialsen
dc.subjectartemisininen
dc.subjectperoxidesen
dc.subjecttrioxanesen
dc.subjecttrioxolanesen
dc.subjecttetraoxanesen
dc.subjectchimerasen
dc.titleArtemisinins and Synthetic Peroxides as Highly Efficient Antimalarialsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractШолаја, Богдан A.; Опсеница, Дејан М.;
dc.citation.volume31
dc.citation.issue2
dc.citation.spage137
dc.citation.epage182
dc.identifier.wos000314145100001
dc.citation.other31(2): 137-182
dc.citation.rankM23
dc.identifier.scopus2-s2.0-84873418208
dc.identifier.rcubKon_2410


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