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Приказ резултата 111-119 од 119
Modeling key interactions between the second extracellular loop of the dopamine D2 receptor and arylpiperazine ligands / Modelovanje ključnih interakcija između druge ekstracelularne petlje dopaminskog D2 receptora i arilpiperazina kao liganada
(Serbian Chemical Soc, Belgrade, 2012)
Second extracellular loop (ec12) of the dopamine (DA) D2 receptor is an essential part of the binding pocket of dopaminergic ligands. To form a part of the ligand-binding surface, it has to fold down into the transmembrane ...
Synthesis of novel 2-(piperazino-1-yl-alkyl)-1H-benzimidazole derivates and assessment of their interactions with the D2 dopamine receptor
(Beograd : Srpsko hemijsko društvo, 2019)
A total of 14 novel arylpiperazines were synthesized, and pharmaco-logically evaluated by measuring their affinities towards the D2 dopamine receptor (DRD2) in a [3H]spiperone competition assay. All the herein described ...
Synthesis and biological evaluation of 5-substituted derivatives of benzimidazole
(Serbian Chemical Soc, Belgrade, 2014)
A series of eight novel 5-substituted derivatives of benzimidazole was synthesized by condensation of the corresponding diamine with ethyl 4-[4-(2-chlorophenyl)piperazin-1-yl]butanoate in refluxing 4 M hydrochloric acid. ...
Investigation of key interactions between the second extracellular loop of the dopamine D2 receptor and several hydroxy-N-{[2-(4-phenylpiperazin-1-yl)ethyl]phenyl}nicotinamides
(Serbian Chemical Soc, Belgrade, 2014)
The dopaminergic receptor system has been the focus for the development of new pharmacotherapeutic agents targeting a number of central nervous system related disorders, such as drug addiction, schizophrenia, depression, ...
Antibacterial and antifungal properties of guanylhydrazones
(Serbian Chemical Soc, Belgrade, 2017)
A series of novel guanylhydrazones were designed, synthesized and characterized. All the compounds were screened for their antibacterial and antifungal activity. Compounds 26 and 27 showed excellent antibacterial activities ...
Synthesis, biological evaluation and docking analysis of substituted piperidines and (2-methoxyphenyl)piperazines
(Serbian Chemical Soc, Belgrade, 2016)
A series of sixteen novel substituted piperidines and (2-methoxyphenyl)piperazines were synthesized, starting from the key intermediates 1-(2-methoxyphenyl)-4-(piperidin-4-yl)piperazine and 1-(2-methoxyphenyl)-4-[(piperi ...
Production of lipase from Pseudozyma aphidis and determination of the activity and stability of the crude lipase preparation in polar organic solvents / Proizvodnja lipaze iz Pseudozyma aphidis i utvrđivanje aktivnosti i stabilnosti lipaze u polarnim organskim rastvaračima
(Serbian Chemical Soc, Belgrade, 2011)
The production of lipase from Pseudozyma aphidis (DSM 70725) was determined in six different media. The highest lipase production was observed in a medium with glucose as the sole carbon source, and yeast extract and sodium ...
Diastereoselective addition of alkenylchromium(III) reagents to Garner's aldehyde. The Nozaki-Hiyama-Kishi coupling approach to sphingosines and ceramides
(Serbian Chemical Soc, Belgrade, 2014)
Intermolecular Nozaki-Hiyama-Kishi coupling between alkenylchromium(III) reagents, derived from either (E)-(2-bromoethenyl)benzene or (E)-1-iodo-1-pentadecene, and the conformationally rigid Garner's aldehyde resulted in ...
Synthesis of two novel C-19 analogues of (±)-alstoscholarisine A
(Beograd : Srpsko hemijsko društvo, 2019)
Two new analogues of alstoscholarisine A, containing a phenyl or butyl substituent at the C-19 position, have been prepared in racemic form from the known skatole derivative. The syntheses of these compounds were accomplished ...