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Приказ резултата 421-430 од 432
N-{[2-(4-Phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides with Dopamine D-2 and 5-Hydroxytryptamine 5HT(1A) Activity: Synthesis, Testing, and Molecular Modeling
(Wiley-V C H Verlag Gmbh, Weinheim, 2013)
The ratio of affinities toward the dopamine D-2 and the 5-hydroxytryptamine 5-HT1A receptors is one of the important parameters that determine the efficiency of antipsychotic drugs. Here, we present the synthesis of ortho-, ...
Consensus-based comparison of chromatographic and computationally estimated lipophilicity of benzothiepino[3,2-c]pyridine derivatives as potential antifungal drugs
(Wiley-V C H Verlag Gmbh, Weinheim, 2017)
Lipophilicity is one of the essential properties influencing drug absorption, excretion and metabolism. It is used for screening viable drug candidates. Chromatographic behavior of thiepino[3,2-c: 6,7-c'] dipyridine and ...
Consensus-based comparison of chromatographic and computationally estimated lipophilicity of benzothiepino[3,2-c]pyridine derivatives as potential antifungal drugs
(Wiley-V C H Verlag Gmbh, Weinheim, 2017)
Lipophilicity is one of the essential properties influencing drug absorption, excretion and metabolism. It is used for screening viable drug candidates. Chromatographic behavior of thiepino[3,2-c: 6,7-c'] dipyridine and ...
Pharmacological Evaluation of Halogenated and Non-halogenated Arylpiperazin-1-yl-ethyl-benzimidazoles as D-2 and 5-HT2A Receptor Ligands
(Wiley-Blackwell, Malden, 2011)
Five groups of previously synthesized and initially screened non-substituted and 4-halogenated arylpiperazin-1-yl-ethyl-benzimidazoles were estimated for their in-vitro binding affinities at the rat D-2, 5-HT2A, and ...
The mechanisms responsible for neuroprotective capacity of arylpiperazine dopaminergic ligands against cell death induced by sodium nitroprusside
(Elsevier Science Bv, Amsterdam, 2012)
A group of sixteen arylpiperazines had been previously synthesized and evaluated for atypical antipsychotic activity. Here we examined these compounds for their neuroprotective capacity. The affinity and agonist/antagonist ...
Structure-retention relationship study of arylpiperazines by linear multivariate modeling
(Wiley-V C H Verlag Gmbh, Weinheim, 2010)
A quantitative structure retention relationship study has been performed to correlate the retention of 33 newly synthesized arylpiperazines with their molecular characteristics, using thin-layer chromatography. Principal ...
Interactions of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl-acetamides and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas with dopamine D-2 and 5-hydroxytryptamine 5HT(1A) receptors
(Pergamon-Elsevier Science Ltd, Oxford, 2012)
It is suggested that the ratio of dopamine D-2 to 5-hydroxytryptamine 5-HT1A activity is an important parameter that determines the efficiency of antipsychotic drugs. Here we present the synthesis of N-{[2-(4-phenyl-pipe ...
Synthesis and anti-Candida activity of novel benzothiepino[3,2-c]pyridine derivatives
(Wiley, Hoboken, 2016)
A novel series of thiepine derivatives were synthesized and evaluated as potential antimicrobials. All the synthesized compounds were evaluated for their antimicrobial activities in vitro against the fungi Candida albicans ...
Gold(I)-Catalyzed C-O/C-C Bond-Forming Domino Reactions and Their Synthetic Applications
(Wiley-V C H Verlag Gmbh, Weinheim, 2018)
The advent of gold catalysis has transformed hydroxyalkoxylation of alkynes - once a rudimentary, mercury(II)-, or silver(I)-catalyzed process limited to structurally simple substrates - into a sophisticated method that ...
Total Synthesis of (+/-)-Alstoscholarisine A
(Georg Thieme Verlag Kg, Stuttgart, 2016)