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Carbon-bromine cleavage by dimethyl sulfoxide: the key step of C(5) functionalization of push-pull 2-alkylidene-4-oxothiazolidine vinyl bromides
(Pergamon-Elsevier Science Ltd, Oxford, 2007)
Push-pull 2-alkylidene-4-oxothiazolidine vinyl bromides undergo efficient C(5) functionalization through DMSO-assisted carbon-bromine cleavage, followed by a bromine transfer-substitution (or elimination) sequence. A ...
Alkylation of carbonyl compounds in the TiCl4-promoted reaction of trimethylsilyl enol ethers with ethylene oxide
(Pergamon-Elsevier Science Ltd, Oxford, 2000)
Titanium tetrachloride promoted reaction of trimethylsilyl enol ethers with ethylene oxide affords homoaldol type products in moderate/good yields. The reaction is believed to proceed via the titanium enolates. (C) 2000 ...
A useful synthetic equivalent of an acetone enolate
(Pergamon-Elsevier Science Ltd, Oxford, 2009)
2-Methoxymethoxy-3-chloropropene derived organometallics act as synthetic equivalents of an acetone enolate. Indium-promoted reaction of this reagent with aldehydes affords aldol adducts in moderate to excellent yields. ...
Palladium-catalyzed cross-couplings of allylic phosphates
(Pergamon-Elsevier Science Ltd, Oxford, 2009)
A range of palladium-catalyzed cross-coupling reactions can be performed using allylic phosphates as electrophiles. Both conventional heating and microwave irradiation can be used. (C) 2009 Elsevier Ltd. All rights reserved.
Intermolecular free radical additions to strained cycloalkenes. Cyclopropene and cyclobutene as radical accepters
(Pergamon-Elsevier Science Ltd, Oxford, 2000)
Intermolecular additions of electrophilic radicals to cyclopropene and cyclobutene derivatives afford the addition products in 37-50% yield. The strain relief in the intermediary radical accelerates the addition, as shown ...
Titanium tetrachloride promoted reaction of silyl ketene acetals with epoxides: a new method for the synthesis of gamma-butanolides
(Pergamon-Elsevier Science Ltd, Oxford, 2002)
A new method for the synthesis of gamma-butanolides is described. The titanium tetrachloride promoted reaction of silyl ketene acetals with epoxides, followed by acidic work-up, affords the corresponding butyrolactones in ...
A simple and efficient one-step, regioselective, enzymatic glucosylation of arbutin by alpha-glucosidase
(Pergamon-Elsevier Science Ltd, Oxford, 2007)
4-Hydroxyphenyl-beta-isomaltoside has been synthesized by alpha-glucosidase assisted transglycosylation between arbutin as acceptor and sucrose as donor molecules, respectively. Optimum conditions for the transglucosylation ...
A novel and efficient 4-oxothiazolidine-1,2-dithiole rearrangement induced by Lawesson's reagent
(Pergamon-Elsevier Science Ltd, Oxford, 2003)
Functionalized 1,2-dithioles have been synthesized by a ring opening-closing process of 5-substituted- and 5-unsubstituted-2-alkylidene-4-oxothiazolidines with Lawesson's reagent. The C-13 NMR data confirmed the meso-ionic ...
Reactions of ortho-substituted alpha,alpha-dibromoacetophenones with nucleophiles: first examples of combined carbophilic and bromophilic attack on C-Br bonds
(Pergamon-Elsevier Science Ltd, Oxford, 2009)
An efficient method for the formation of alpha-carbonyl-monosubstituted acetophenones from ortho-methoxy-and ortho-hydroxy-alpha,alpha-dibromoacetopheiiones and a range of selected nucleophiles, occurring via a carbophilic ...
A novel tandem process leading to functionalized glutarimides
(Pergamon-Elsevier Science Ltd, Oxford, 2005)
The synthesis of various functionalized or spirobicyclic glutarimides by a novel tandem process has been disclosed. The reaction involves a base-catalyzed Michael addition of active methylene compounds to secondary conjugated ...