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Interakcije antitumorskog seskviterpenskog hidrohinona avarola sa DNA in vitro

dc.creatorVujčić, Miroslava
dc.creatorTufegdzic, Srdan
dc.creatorVujčić, Zoran
dc.creatorGasic, Miroslav J.
dc.creatorSladić, Dušan
dc.date.accessioned2018-11-22T00:11:55Z
dc.date.available2018-11-22T00:11:55Z
dc.date.issued2007
dc.identifier.issn0352-5139
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/905
dc.description.abstractChanges in electrophoresis pattern after interaction of supercoiled plasmid pBR322 DNA with avarol was studied at a micromolar concentration of reactants under mild reaction conditions. Interactions of avarol with linear high-molecular CT-DNA at millimolar concentrations were analyzed by electrophoresis and UV spectrophotometry. It was observed that avarol is capable of quenching ethidium bromide fluorescence in DNA bands. An increase in the absorbance of DNA was detected. The results indicate the binding of avarol to DNA and/or modification of nucleotide bases.en
dc.description.abstractProučavane su promene elektroforetskog ponašanja DNA posle interakcija superhelikoidalnog plazmida pBR322 s avarolom pri mikromolarnim koncentracijama reaktanata pod blagim reakcionim uslovima. Interakcije avarola sa linearnom visokomolekulskom CT-DNA pri milimolarnim koncentracijama analizirane su elektroforezom i UV spektrofotometrijom. Uočeno je da je avarol u stanju da gasi fluorescenciju etidijum-bromida u trakama koje potiču od DNA. Detektovan je porast apsorbancije DNA. Rezultati ukazuju na vezivanje avarona za DNA i/ili modifikaciju nukleotidnih baza.sr
dc.publisherSerbian Chemical Soc, Belgrade
dc.rightsopenAccess
dc.sourceJournal of the Serbian Chemical Society
dc.subjectavarolen
dc.subjecthydroquinoneen
dc.subjecthydroquinoneen
dc.subjectanti-tumor activityen
dc.subjectanti-tumor activityen
dc.subjectpBR322 DNAen
dc.subjectpBR322 DNAen
dc.subjectcalf thymus DNAen
dc.subjectcalf thymus DNAen
dc.titleInteractions of the anti-tumor sesquiterpene hydroquinone avarol with DNA in vitroen
dc.titleInterakcije antitumorskog seskviterpenskog hidrohinona avarola sa DNA in vitrosr
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractВујциц, Мирослава; Сладић, Душан; Гасиц, Мирослав Ј.; Туфегдзиц, Срдан; Вујчић, Зоран; Интеракције антитуморског сесквитерпенског хидрохинона аварола са ДНA ин витро; Интеракције антитуморског сесквитерпенског хидрохинона аварола са ДНA ин витро;
dc.citation.volume72
dc.citation.issue12
dc.citation.spage1265
dc.citation.epage1269
dc.identifier.wos000252412100010
dc.identifier.doi10.2298/JSC0712265V
dc.citation.other72(12): 1265-1269
dc.citation.rankM23
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-36949006977
dc.identifier.rcubKon_1858


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