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Ruthenium(II)-arene complexes with substituted picolinato ligands: Synthesis, structure, spectroscopic properties and antiproliferative activity
dc.creator | Ivanović, Ivanka | |
dc.creator | Jovanović, Katarina K. | |
dc.creator | Gligorijević, Nevenka | |
dc.creator | Radulović, Siniša | |
dc.creator | Arion, Vladimir B. | |
dc.creator | Sheweshein, Khalil Salem A. M. | |
dc.creator | Tešić, Živoslav Lj. | |
dc.creator | Grgurić-Šipka, Sanja | |
dc.date.accessioned | 2018-11-22T00:26:47Z | |
dc.date.available | 2018-11-22T00:26:47Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0022-328X | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/1451 | |
dc.description.abstract | A series of seven new ruthenium(II)-arene complexes of general formula [Ru(eta(6)-p-cymene)(L1-7)Cl], where L1-7 are fluoro, chloro, bromo or methyl derivatives of picolinic acid or isoquinoline-3-carboxylic acid has been synthesized and characterized by elemental analysis, IR, H-1 and C-13 NMR spectroscopy and ESI mass spectrometry. X-ray diffraction studies of two compounds showed the usual piano-stool geometry, with coordination of picolinato ligands through the pyridine nitrogen and the carboxylic group oxygen atom (N/COO- donor set). Cytotoxicity of complexes in vitro has been evaluated in three human tumor cell lines: cervix carcinoma (HeLa), melanoma (FemX), lung adenocarcinoma (A549) and one normal cell line (MRC-5). Complex with isoqinoline-3-carboxylic acid as ligand, exhibited significantly lower cytotoxic activity in normal cells (MRC-5) against high activity observed in panel of tumor cells and prominent cell type selectivity among tumor cells. (C) 2013 Elsevier B. V. All rights reserved. | en |
dc.publisher | Elsevier Science Sa, Lausanne | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41026/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172017/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Organometallic Chemistry | |
dc.subject | Ruthenium(II)-arene | en |
dc.subject | Picolinato ligands | en |
dc.subject | X-ray diffraction | en |
dc.subject | Anticancer activity | en |
dc.title | Ruthenium(II)-arene complexes with substituted picolinato ligands: Synthesis, structure, spectroscopic properties and antiproliferative activity | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Aрион, Владимир Б.; Јовановиц, Катарина К.; Глигоријевиц, Невенка; Тешић, Живослав Љ.; Ивановиц, Иванка; Гргурић-Шипка, Сања; Схеwесхеин, Кхалил Салем A. М.; Радуловиц, Синиса; | |
dc.citation.volume | 749 | |
dc.citation.spage | 343 | |
dc.citation.epage | 349 | |
dc.identifier.wos | 000327939000050 | |
dc.identifier.doi | 10.1016/j.jorganchem.2013.10.023 | |
dc.citation.other | 749: 343-349 | |
dc.citation.rank | M21 | |
dc.type.version | publishedVersion | en |
dc.identifier.scopus | 2-s2.0-84887113529 |