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NaY zeolite: A useful catalyst for nitrile hydrolysis
(Molecular Diversity Preservation International, Basel, 2000)
The NaY zeolite catalysed hydrolysis of nitriles to primary amides is reported. It is found that aryl nitriles with strong electron-withdrawing substituents and cyanopyridines are readily hydrolysed in the water suspension, ...
A new heterocyclization product of adhyperforin from Hypericum perforatum (St. John's wort)
(Molecular Diversity Preservation International, Basel, 2000)
Reactivity and biological activity of the marine sesquiterpene hydroquinone avarol and related compounds from sponges of the order Dictyoceratida
(Mdpi Ag, Basel, 2006)
A review of results of bioactivity and reactivity examinations of marine sesquiterpene (hydro)quinones is presented. The article is focused mostly on friedo-rearranged drimane structural types, isolated from sponges of the ...
Electrochemical Behavior and antioxidant and prooxidant activity of natural phenolics
(Molecular Diversity Preservation Int, Basel, 2007)
We have investigated the electrochemical oxidation of a number natural phenolics ( salicylic acid, m-hydroxybenzoic acid, p-hydroxybenzoic acid, protocatechuic acid, o-coumaric acid, m-coumaric acid, p-coumaric acid, caffeic ...
A high.throughput screening system based on droplet microfluidics for glucose oxidase gene libraries
(MDPI, 2020)
Glucose oxidase (GOx) is an important industrial enzyme that can be optimized for specific applications by mutagenesis and activity.based screening. To increase the efficiency of this approach, we have developed a new ...
On the Protein Fibrillation Pathway: Oligomer Intermediates Detection Using ATR-FTIR Spectroscopy
(MDPI, 2021)
Oligomeric intermediates on the pathway of amyloid fibrillation are suspected as the main cytotoxins responsible for amyloid-related pathogenicity. As they appear to be a part of the lag phase of amyloid fibrillation when ...
X-ray crystal structure of 10 beta-hydroxy-4 beta,5 beta P-epoxyestr-1-en-3,17-dione and antitumor activity of its congeners
(Mdpi Ag, Basel, 1999)
Based on the biological properties of epoxyquinols from natural sources, the title compound was synthesised as a potential antitumor agent. Its molecular structure was partially confirmed by NMR studies. The detailed ...
Antimalarials with Benzothiophene Moieties as Aminoquinoline Partners
(Mdpi Ag, Basel, 2017)
Malaria is a severe and life-threatening disease caused by Plasmodium parasites that are spread to humans through bites of infected Anopheles mosquitoes. Here, we report on the efficacy of aminoquinolines coupled to ...
Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator
(Mdpi, Basel, 2018)
Pseudomonas aeruginosa is one of the most dreaded human pathogens, because of its intrinsic resistance to a number of commonly used antibiotics and ability to form sessile communities (biofilms). Innovative treatment ...
Lipophilicity determination of antifungal isoxazolo[3,4-b]pyridin-3(1h)-ones and their n1-substituted derivatives with chromatographic and computational methods
(Molecules, 2019)
The lipophilicity of a molecule is a well-recognized as a crucial physicochemical factor that conditions the biological activity of a drug candidate. This study was aimed to evaluate the lipophilicity of isoxazolo[3,4-b] ...