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Straightforward access to novel mitochondriotropics derived from 2-arylethanol as potent and selective antiproliferative agents
(Elsevier, 2022)
The necessity for developing novel cytostatic agents with improved activities and reduced side-effects to tackle cancer prompted us to investigate mitochondria-targeted compounds, an approach that is gaining attention for ...
4-Aminoquinoline-based compounds as antileishmanial agents that inhibit the energy metabolism of Leishmania
(Elsevier, 2019)
Among neglected tropical diseases, leishmaniasis is one of the most relevant with an estimated 30,000 deaths annually. Existing therapies have serious drawbacks in safety, drug resistance, field-adapted application and ...
Unraveling the anti-virulence potential and antifungal efficacy of 5-aminotetrazoles using the zebrafish model of disseminated candidiasis
(Elsevier, 2022)
Candida albicans remains the main causal agent of candidiasis, the most common fungal infection with disturbingly high mortality rates worldwide. The limited diversity and efficacy of clinical antifungal drugs, exacerbated ...
Study of the anticancer potential of Cd complexes of selenazoyl-hydrazones and their sulfur isosters
(Elsevier, 2022)
The biological activity of Cd compounds has been investigated scarce since Cd has been recognized as a human carcinogen. However, the toxicity of cadmium is comparable to the toxicity of noble metals such as Pt and Pd. The ...