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Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis
dc.creator | Krstić, Gordana B. | |
dc.creator | Jadranin, Milka | |
dc.creator | Todorović, Nina | |
dc.creator | Pešić, Milica | |
dc.creator | Stanković, Tijana | |
dc.creator | Aljančić, Ivana | |
dc.creator | Tešević, Vele | |
dc.date.accessioned | 2018-11-22T00:43:35Z | |
dc.date.available | 2018-11-22T00:43:35Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0031-9422 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/2108 | |
dc.description.abstract | Seven previously undescribed jatrophane diterpenoids, nicaeenin A-G, with eight known jatrophane diterpenoids, namely euphodendrophanes A-C, F, N, O, Q S, were isolated from latex of Euphorbia nicaeensis collected in Serbia. The chemical structures of the compounds were determined by spectro-scopic analysis including 1D and 2D NMR and HRESIMS experiments. All but one of the previously undescribed jatrophanes, showed significant potential to inhibit P-glycoprotein (P-gp) activity in two MDR cancer cells (NCI-H460/12 and DLD1-TxR). The most powerful were nicaeenin F and nicaeenin G. Moreover nicaeenin G significantly stronger sensitized NCI-H460/R cells to DOX than Dex-VER. (C) 2018 Elsevier Ltd. All rights reserved. | en |
dc.publisher | Pergamon-Elsevier Science Ltd, Oxford | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41031/RS// | |
dc.rights | restrictedAccess | |
dc.source | Phytochemistry | |
dc.subject | Euphorbia nicaeensis | en |
dc.subject | Euphorbiaceae | en |
dc.subject | Diterpenoids | en |
dc.subject | Jatrophanes | en |
dc.subject | Isolation | en |
dc.subject | Structutre determination | en |
dc.subject | P-glycoprotein | en |
dc.subject | Multi-drug resistance | en |
dc.title | Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Јадранин, Милка; Aљанциц, Ивана С.; Тешевић, Веле; Крстић, Гордана; Тодоровиц, Нина М.; Станковиц, Тијана; Песиц, Милица; | |
dc.citation.volume | 148 | |
dc.citation.spage | 104 | |
dc.citation.epage | 112 | |
dc.identifier.wos | 000427334600013 | |
dc.identifier.doi | 10.1016/j.phytochem.2018.01.016 | |
dc.citation.other | 148: 104-112 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 29421506 | |
dc.description.other | Supplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3234] | |
dc.type.version | publishedVersion | en |
dc.identifier.scopus | 2-s2.0-85041594265 |