Приказ основних података о документу
Docking studies suggest ligand-specific delta-opioid receptor conformations
dc.creator | Micovic, Vuk | |
dc.creator | Ivanović, Milovan | |
dc.creator | Došen-Mićović, Ljiljana | |
dc.date.accessioned | 2018-11-22T00:14:35Z | |
dc.date.available | 2018-11-22T00:14:35Z | |
dc.date.issued | 2009 | |
dc.identifier.issn | 1610-2940 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/872 | |
dc.description.abstract | An automated docking procedure was used to study binding of a series of delta-selective ligands to three models of the delta-opioid receptor. These models are thought to represent the three ligand-specific receptor conformations. Docking results are in agreement with point mutation studies and suggest that different ligands-agonists and antagonists-may bind to the same binding site under different receptor conformations. Docking to different receptor models ( conformations) also suggests that by changing to a receptor-specific conformation, the receptor may open or close different binding sites to other ligands. | en |
dc.publisher | Springer, New York | |
dc.relation | Ministry of Science and Environmental Protection of the Republic of Serbia | |
dc.rights | restrictedAccess | |
dc.source | Journal of Molecular Modeling | |
dc.subject | Delta opioid receptor | en |
dc.subject | Docking simulation | en |
dc.subject | Ligand-receptor interactions | en |
dc.subject | Molecular modeling | en |
dc.title | Docking studies suggest ligand-specific delta-opioid receptor conformations | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Мицовиц, Вук; Ивановић, Милован; Досен-Мицовиц, Љиљана; | |
dc.citation.volume | 15 | |
dc.citation.issue | 3 | |
dc.citation.spage | 267 | |
dc.citation.epage | 280 | |
dc.identifier.wos | 000262578200005 | |
dc.identifier.doi | 10.1007/s00894-008-0396-7 | |
dc.citation.other | 15(3): 267-280 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 19052783 | |
dc.type.version | publishedVersion | en |
dc.identifier.scopus | 2-s2.0-59149102761 |