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Anti-Ebola Activity of Diazachrysene Small Molecules
dc.creator | Selaković, Života | |
dc.creator | Soloveva, Veronica | |
dc.creator | Gharaibeh, Dima N. | |
dc.creator | Wells, Jay | |
dc.creator | Šegan, Sandra B. | |
dc.creator | Panchal, Rekha G. | |
dc.creator | Šolaja, Bogdan A. | |
dc.date.accessioned | 2018-11-22T00:33:31Z | |
dc.date.available | 2018-11-22T00:33:31Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 2373-8227 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/2035 | |
dc.description.abstract | Herein we report on a diazachrysene class of small molecules that exhibit potent antiviral activity against the Ebola (EBOV) virus. The antiviral compounds are easily synthesized, and the most active compounds have excellent in vitro activity (0.34-0.70 mu M) and are significantly less lipophilic than their predecessors. The three most potent diazachrysene antivirals do not exhibit any toxicity in vivo and protected 70-90% of the mice at 10 mg/kg following EBOV challenge. Together, these studies suggest that diazachrysenes are a promising class of compounds for hit to lead optimization and as potential Ebola therapeutics. | en |
dc.publisher | Amer Chemical Soc, Washington | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172008/RS// | |
dc.relation | Department of Defense Chemical Biological Defense Program through Defense Threat Reduction Agency (DTRA) | |
dc.rights | restrictedAccess | |
dc.source | ACS INFECTIOUS DISEASES | |
dc.subject | Ebola virus | en |
dc.subject | antiviral diazachrysenes | en |
dc.subject | inhibitory efficacy small molecule | en |
dc.subject | toxicity | en |
dc.title | Anti-Ebola Activity of Diazachrysene Small Molecules | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Гхараибех, Дима Н.; Wеллс, Јаy; Панцхал, Рекха Г.; Сеган, Сандра; Селаковић, Живота; Шолаја, Богдан A.; Соловева, Вероница; | |
dc.citation.volume | 1 | |
dc.citation.issue | 6 | |
dc.citation.spage | 264 | |
dc.citation.epage | 271 | |
dc.identifier.wos | 000368463600005 | |
dc.identifier.doi | 10.1021/acsinfecdis.5b00028 | |
dc.citation.other | 1(6): 264-271 | |
dc.citation.rank | M23 | |
dc.identifier.pmid | 27622742 | |
dc.description.other | Supplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3339] | |
dc.type.version | publishedVersion | en |
dc.identifier.scopus | 2-s2.0-84969135965 |