Epithelial models to study food allergen-induced barrier disruption and immune activation
Samo za registrovane korisnike
2015
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Changes in lifestyle, diet and environmental factors in westernized countries correspond with the rise in non-communicable diseases affecting metabolic and immune disorders, such as allergies. Therefore the mechanisms by which environmental factors and allergens are capable of elicitating allergic sensitization need to be further unraveled. In vitro models using human epithelial cells, with or without immune cells, are needed to achieve this purpose. Epithelial cells cover mucosal surfaces and provide a barrier between the external and internal environment. In mucosal tissues such as the respiratory and gastro-intestinal tract, epithelial cells not only contribute to barrier integrity but also actively regulate dendritic cell function and adaptive immune responses and can support tolerance induction or allergic sensitization. Certain allergens contain protease activity which may facilitate them to cross the barrier, others are transported via transcytosis. In addition, certain allergen...s may provoke epithelial activation resulting in production of TH2 driving immune mediators. Preserving epithelial homeostasis is important to suppress allergic sensitization. This review describes in vitro models of human intestinal epithelial cells and co-culture models that are currently available to determine barrier disruption or immune activation induced by food allergens. These can be used for future development of in vitro models to study the contribution of intestinal epithelial cells in allergic sensitization and to identify sensitizing properties of novel proteins. © 2016 Elsevier Ltd
Izvor:
Drug Discovery Today: Disease Models, 2015, 29-36Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Gavrović-Jankulović, Marija AU - Willemsen, Linette E.M. PY - 2015 UR - https://cherry.chem.bg.ac.rs/handle/123456789/303 AB - Changes in lifestyle, diet and environmental factors in westernized countries correspond with the rise in non-communicable diseases affecting metabolic and immune disorders, such as allergies. Therefore the mechanisms by which environmental factors and allergens are capable of elicitating allergic sensitization need to be further unraveled. In vitro models using human epithelial cells, with or without immune cells, are needed to achieve this purpose. Epithelial cells cover mucosal surfaces and provide a barrier between the external and internal environment. In mucosal tissues such as the respiratory and gastro-intestinal tract, epithelial cells not only contribute to barrier integrity but also actively regulate dendritic cell function and adaptive immune responses and can support tolerance induction or allergic sensitization. Certain allergens contain protease activity which may facilitate them to cross the barrier, others are transported via transcytosis. In addition, certain allergens may provoke epithelial activation resulting in production of TH2 driving immune mediators. Preserving epithelial homeostasis is important to suppress allergic sensitization. This review describes in vitro models of human intestinal epithelial cells and co-culture models that are currently available to determine barrier disruption or immune activation induced by food allergens. These can be used for future development of in vitro models to study the contribution of intestinal epithelial cells in allergic sensitization and to identify sensitizing properties of novel proteins. © 2016 Elsevier Ltd T2 - Drug Discovery Today: Disease Models T1 - Epithelial models to study food allergen-induced barrier disruption and immune activation SP - 29 EP - 36 DO - 10.1016/j.ddmod.2016.09.002 ER -
@article{ author = "Gavrović-Jankulović, Marija and Willemsen, Linette E.M.", year = "2015", abstract = "Changes in lifestyle, diet and environmental factors in westernized countries correspond with the rise in non-communicable diseases affecting metabolic and immune disorders, such as allergies. Therefore the mechanisms by which environmental factors and allergens are capable of elicitating allergic sensitization need to be further unraveled. In vitro models using human epithelial cells, with or without immune cells, are needed to achieve this purpose. Epithelial cells cover mucosal surfaces and provide a barrier between the external and internal environment. In mucosal tissues such as the respiratory and gastro-intestinal tract, epithelial cells not only contribute to barrier integrity but also actively regulate dendritic cell function and adaptive immune responses and can support tolerance induction or allergic sensitization. Certain allergens contain protease activity which may facilitate them to cross the barrier, others are transported via transcytosis. In addition, certain allergens may provoke epithelial activation resulting in production of TH2 driving immune mediators. Preserving epithelial homeostasis is important to suppress allergic sensitization. This review describes in vitro models of human intestinal epithelial cells and co-culture models that are currently available to determine barrier disruption or immune activation induced by food allergens. These can be used for future development of in vitro models to study the contribution of intestinal epithelial cells in allergic sensitization and to identify sensitizing properties of novel proteins. © 2016 Elsevier Ltd", journal = "Drug Discovery Today: Disease Models", title = "Epithelial models to study food allergen-induced barrier disruption and immune activation", pages = "29-36", doi = "10.1016/j.ddmod.2016.09.002" }
Gavrović-Jankulović, M.,& Willemsen, L. E.M.. (2015). Epithelial models to study food allergen-induced barrier disruption and immune activation. in Drug Discovery Today: Disease Models, 29-36. https://doi.org/10.1016/j.ddmod.2016.09.002
Gavrović-Jankulović M, Willemsen LE. Epithelial models to study food allergen-induced barrier disruption and immune activation. in Drug Discovery Today: Disease Models. 2015;:29-36. doi:10.1016/j.ddmod.2016.09.002 .
Gavrović-Jankulović, Marija, Willemsen, Linette E.M., "Epithelial models to study food allergen-induced barrier disruption and immune activation" in Drug Discovery Today: Disease Models (2015):29-36, https://doi.org/10.1016/j.ddmod.2016.09.002 . .