Evaluation of the lipophilicity of some 1-arylpiperazines by planar chromatography

Abstract

The lipophilic character of some biologically active 1-arylpiperazines has been studied. A reversed-phase planar chromatographic procedure was established for determination of log Po-w values (n-octanol-water partition coefficients) for the compounds. The compounds were chromatographed with five so-called 'standards' on RP-18 silica plates with methanol-water and dioxane-water binary systems as mobile phases. n-Octanol-water partition coefficients for five standard compounds determined experimentally by use of the shake-flask method were used to obtain the log Po-w values of the 1-arylpiperazines investigated. Experimentally established log Po-w values were compared with log P values calculated by use of five different software packages.