Bromide determination in pharmaceutical preparations using indirect gas-diffusion flow injection method with amperometric detector
Apstrakt
The indirect gas-diffusion flow injection method (FI) was modified, optimized and successfully applied to bromide determination in various samples such as active substances, drugs, organic substances and water samples. The method is based on the oxidation of bromide to bromine in acidic medium, which diffuses through PTFE membrane into the acceptor flow that carried bromine to the amperometric cell. The flow amperometric detection was carried out at the potential of +0.65 V (vs Ag/AgCl) when injected sample volume was 100 mu L. Results obtained by FIA were confirmed by cyclic voltarnmetry (CV). The linear calibration graph was obtained over the concentration range 0.1-10x10(-3) mol/L and 2.5-100x10(-6) mol/L bromide solutions. Relative standard deviation was 1.23% for 5x10(-6) mol/L bromide solution and 0. 11% for 0.25x10(-3)mol/L bromide solution (n=6, for both cases). The limit of detection was 5x10(-1) mol/L. The described method requires small quantities of samples and prior extrac...tion of the analytes is not necessary. The method enables 60 analyses per hour.
Ključne reči:
bromide / gas-diffusion / amperometric detection / pharmaceutical active substances / drugsIzvor:
Polish Journal of Environmental Studies, 2007, 16, 5, 739-744Izdavač:
- Hard, Olsztyn 5
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Mutić, Jelena AU - Nikolić-Mandić, Snežana D. AU - Lolić, Aleksandar AU - Manojlović, Dragan D. PY - 2007 UR - https://cherry.chem.bg.ac.rs/handle/123456789/869 AB - The indirect gas-diffusion flow injection method (FI) was modified, optimized and successfully applied to bromide determination in various samples such as active substances, drugs, organic substances and water samples. The method is based on the oxidation of bromide to bromine in acidic medium, which diffuses through PTFE membrane into the acceptor flow that carried bromine to the amperometric cell. The flow amperometric detection was carried out at the potential of +0.65 V (vs Ag/AgCl) when injected sample volume was 100 mu L. Results obtained by FIA were confirmed by cyclic voltarnmetry (CV). The linear calibration graph was obtained over the concentration range 0.1-10x10(-3) mol/L and 2.5-100x10(-6) mol/L bromide solutions. Relative standard deviation was 1.23% for 5x10(-6) mol/L bromide solution and 0. 11% for 0.25x10(-3)mol/L bromide solution (n=6, for both cases). The limit of detection was 5x10(-1) mol/L. The described method requires small quantities of samples and prior extraction of the analytes is not necessary. The method enables 60 analyses per hour. PB - Hard, Olsztyn 5 T2 - Polish Journal of Environmental Studies T1 - Bromide determination in pharmaceutical preparations using indirect gas-diffusion flow injection method with amperometric detector VL - 16 IS - 5 SP - 739 EP - 744 UR - https://hdl.handle.net/21.15107/rcub_cherry_869 ER -
@article{ author = "Mutić, Jelena and Nikolić-Mandić, Snežana D. and Lolić, Aleksandar and Manojlović, Dragan D.", year = "2007", abstract = "The indirect gas-diffusion flow injection method (FI) was modified, optimized and successfully applied to bromide determination in various samples such as active substances, drugs, organic substances and water samples. The method is based on the oxidation of bromide to bromine in acidic medium, which diffuses through PTFE membrane into the acceptor flow that carried bromine to the amperometric cell. The flow amperometric detection was carried out at the potential of +0.65 V (vs Ag/AgCl) when injected sample volume was 100 mu L. Results obtained by FIA were confirmed by cyclic voltarnmetry (CV). The linear calibration graph was obtained over the concentration range 0.1-10x10(-3) mol/L and 2.5-100x10(-6) mol/L bromide solutions. Relative standard deviation was 1.23% for 5x10(-6) mol/L bromide solution and 0. 11% for 0.25x10(-3)mol/L bromide solution (n=6, for both cases). The limit of detection was 5x10(-1) mol/L. The described method requires small quantities of samples and prior extraction of the analytes is not necessary. The method enables 60 analyses per hour.", publisher = "Hard, Olsztyn 5", journal = "Polish Journal of Environmental Studies", title = "Bromide determination in pharmaceutical preparations using indirect gas-diffusion flow injection method with amperometric detector", volume = "16", number = "5", pages = "739-744", url = "https://hdl.handle.net/21.15107/rcub_cherry_869" }
Mutić, J., Nikolić-Mandić, S. D., Lolić, A.,& Manojlović, D. D.. (2007). Bromide determination in pharmaceutical preparations using indirect gas-diffusion flow injection method with amperometric detector. in Polish Journal of Environmental Studies Hard, Olsztyn 5., 16(5), 739-744. https://hdl.handle.net/21.15107/rcub_cherry_869
Mutić J, Nikolić-Mandić SD, Lolić A, Manojlović DD. Bromide determination in pharmaceutical preparations using indirect gas-diffusion flow injection method with amperometric detector. in Polish Journal of Environmental Studies. 2007;16(5):739-744. https://hdl.handle.net/21.15107/rcub_cherry_869 .
Mutić, Jelena, Nikolić-Mandić, Snežana D., Lolić, Aleksandar, Manojlović, Dragan D., "Bromide determination in pharmaceutical preparations using indirect gas-diffusion flow injection method with amperometric detector" in Polish Journal of Environmental Studies, 16, no. 5 (2007):739-744, https://hdl.handle.net/21.15107/rcub_cherry_869 .